Inhibition of acetylcholine synthesis and tyrosine nitration induced by peroxynitrite are differentially prevented by antioxidants

Molecular Pharmacology

Volumn 60, Issue 4, 2001, Pages 838-846

  Guermonprez, Lydie ^a   Ducrocq, Claire ^b   Gaudry Talarmain, Yvette Morot ^a  

^a LABORATOIRE DE NEUROBIOLOGIE CELLULAIRE ET MOLÉCULAIRE   (France)

^b CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

3 NITROTYROSINE; ACETYLCHOLINE; ACETYLCYSTEINE; ANTIOXIDANT; BOVINE SERUM ALBUMIN; CHOLINE; CYSTEINE; DEFEROXAMINE; DITHIOTHREITOL; GLUTATHIONE; LINSIDOMINE; MELATONIN; NERVE PROTEIN; NITRIC OXIDE; PEROXYNITRITE; REACTIVE OXYGEN METABOLITE; TYROSINE; URIC ACID;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL TISSUE; ANTICHOLINERGIC EFFECT; ANTIOXIDANT ACTIVITY; ARTICLE; CHOLINERGIC ACTIVITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DEGENERATIVE DISEASE; NEUROMUSCULAR SYNAPSE; NEUROTRANSMITTER UPTAKE; NITRATION; NONHUMAN; OXIDATION; PRIORITY JOURNAL; SYNAPSE VESICLE; SYNAPTOSOME; TORPEDO MARMORATA;

ACETATES; ACETYLCHOLINE; ANIMALS; ANTIOXIDANTS; BIOLOGICAL TRANSPORT; CARBON RADIOISOTOPES; CHOLINE; CHOLINE O-ACETYLTRANSFERASE; DRUG INTERACTIONS; MOLSIDOMINE; NITRATES; OXIDANTS; REDUCING AGENTS; TORPEDO; TYROSINE; URIC ACID;

EID: 0034811593     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (41)

1. Inactivation of tyrosine hydroxylase by nitration following exposure to peroxynitrite and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)
2. Protection against peroxynitrite
3. Increased 3-nitrotyrosine in both sporadic and familial amyotrophic lateral sclerosis
4. Apparent hydroxyl radical production by peroxynitrite: Implications for endothelial injury from nitric oxide and superoxide
5. Nitric oxide, superoxide, and peroxynitrite: The good, the bad, and ugly
6. Nitrosation of melatonin by nitric oxide and peroxynitrite
7. Oxygen and oxidation promote the release of nitric oxide from sydnonimines
8. The phosphorylation of choline acetyltransferase
9. Torpedo synaptophysin: Evolution of a synaptic vesicle protein
10. Evidence for a thiol reagent inhibiting choline acetyltransferase by reacting with the thiol group of coenzyme A forming a potent inhibitor
11. Peroxynitrite induces tyrosine nitration and modulates tyrosine phosphorylation of synaptic proteins
12. Expression, purification and characterization of recombinant human choline acetyltransferase: Phosphorylation of the enzyme regulates catalytic activity
13. Effect of N,N′-dicyclohexylcarbodiimide on compartmentation and release of newly synthesized and preformed acetyicholine in Torpedo synaptosomes
14. Microtubule dysfunction by posttranslational nitrotyrosination of alpha-tubulin: A nitric oxide-dependent mechanism of cellular injury
15. On the mechanism of NO release from sydnonimines
16. A rapid radiochemical method for the determination of choline acetyltransferase
17. Protein nitration in Parkinson's disease
18. Multiple isoelectric and molecular weight variants of choline acetyltransferase. Artifact or real?
19. ATP-dependent calcium uptake by cholinergic synaptic vesicles isolated from Torpedo electric organ
20. Peroxynitrite-induced alterations in synaptosomal membrane proteins: Insight into oxidative stress in Alzheimer's disease
21. Peroxynitrite inactivates tryptophan hydroxylase via sulfhydryl oxidation. Coincident nitration of enzyme tyrosyl residues has minimal impact on catalytic activity
22. Dimerization of the synaptic vesicle protein synaptobrevin (vesicle-associated membrane protein) II depends on specific residues within the transmembrane segment
23. Mechanism of carbon dioxide-catalyzed oxidation of tyrosine by peroxynitrite
24. Isolation of pure cholinergic nerve endings from Torpedo electric organ. Evaluation of their metabolic properties
25. Nitric oxide and peroxynitrite affect differently acetylcholine release, choline acetyltransferase activity, synthesis, and compartmentation of newly formed acetylcholine in Torpedo marmorata synaptosomes
26. Opposite actions of nitric oxide on cholinergic synapses: Which pathways?
27. Nitric oxide and peroxynitrite anion modulate liver plasma membrane fluidity and Na(+)/K(+)-ATPase activity
28. Cloned human brain nitric oxide synthase is highly expressed in skeletal muscle
29. Choline acetyltransferase: The structure, distribution and pathologic changes in the central nervous system
30. Identification and characterization of the high-affinity choline transporter
31. Binding of [3H]hemicholinium-3 to the high-affinity choline transporter in electric organ synaptosomal membranes
32. The chemistry of peroxynitrite: A product from the reaction of nitric oxide with superoxide
33. Unraveling peroxynitrite formation in biological systems
34. Tubulin distribution along the Torpedo electroneuron. An immunochemical study
35. Wide-spread peroxynitrite-mediated damage in Alzheimer's disease
36. Dityrosine cross-linking promotes formation of stable alpha-synuclein polymers. Implication of nitrative and oxidative stress in the pathogenesis of neurodegenerative synucle-inopathies
37. Peroxynitrite-mediated modification of proteins at physiological carbon dioxide concentration: pH dependence of carbonyl formation, tyrosine nitration, and methionine oxidation
38. Peroxynitrite inhibits glutamate transporter subtypes
39. Synthesis of peroxynitrite in a two-phase system using isoamyl nitrite and hydrogen peroxide
40. Peroxynitrite modification of protein thiols: Oxidation, nitrosylation, and S-glutathiolation of functionally important cysteine residue(s) in the sarcoplasmic reticulum Ca-ATPase
41. Choline acetyltransferase: Celebrating its fiftieth year