Differentiation of Th1 and Th2 cells in lymph nodes and spleens of mice during experimental autoimmune uveoretinitis

Japanese Journal of Ophthalmology

Volumn 45, Issue 5, 2001, Pages 463-469

  Takeuchi, Masaru ^a   Yokoi, Hidetoshi ^a   Tsukahara, Rintaroh ^a   Sakai, Jun ichi ^a   Usui, Masahiko ^a  

^a TOKYO MEDICAL UNIVERSITY   (Japan)

Author keywords

Autoimmune disease; Experimental autoimmune uveoretinitis; Immunoregulation; Th1 cells; Th2 cells

Indexed keywords

FREUND ADJUVANT; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4; INTERPHOTORECEPTOR RETINOID BINDING PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNE DISEASE; CELL CULTURE; CELLULAR IMMUNITY; CONTROLLED STUDY; CORRELATION FUNCTION; CYTOKINE PRODUCTION; DISEASE COURSE; DISEASE SEVERITY; ENUCLEATION; FEMALE; HISTOPATHOLOGY; IMMUNIZATION; IMMUNOPATHOGENESIS; IMMUNOREGULATION; LYMPH NODE CELL; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE PROLIFERATION; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; SPLEEN CELL; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; TH1 CELL; TH2 CELL; UVEORETINITIS;

ANIMALS; AUTOANTIGENS; AUTOIMMUNE DISEASES; AUTOIMMUNITY; CELL DIFFERENTIATION; EYE PROTEINS; FEMALE; IMMUNIZATION; INTERFERON TYPE II; INTERLEUKINS; LYMPH NODES; LYMPHOCYTE ACTIVATION; MICE; MODELS, ANIMAL; RETINITIS; RETINOL-BINDING PROTEINS; SPLEEN; TH1 CELLS; TH2 CELLS; UVEITIS;

EID: 0034802628     PISSN: 00215155     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0021-5155(01)00369-0     Document Type: Article

References (22)

1. A new model of autoimmune disease. Experimental autoimmune uveoretinitis induced in mice with two different retinal antigens
2. Induction of experimental autoimmune uveoretinitis by T-cell lines
3. Autoimmunity and the retina
4. Th1 and Th2 cells: Different patterns of lymphokine secretion lead to different functional properties
5. An update on human Th1 and Th2 cells
6. Th1 and Th2 CD4+ T cells in the pathogenesis of organ-specific autoimmune diseases
7. Establishment and characterization of a murine CD4+ T cell line and clone that induce experimental autoimmune uveoretinitis in B10.A mice
8. Uveitogenicity is associated with a Th1-like lymphokine profile: Cytokine-dependent modulation of primary and committed T cells in EAU
9. Genetic susceptibility to experimental autoimmune uveitis involves more than a predisposition to generate a T helper-1-like or a T helper-2-like response
10. Genetic susceptibility to experimental autoimmune uveoretinitis in the rat is associated with an elevated Th1 response
11. Prevention of experimental autoimmune uveoretinitis by monoclonal antibody to interleukin-12
12. The kinetics of cytokine mRNA expression in the retina during experimental autoimmune uveoretinitis
13. IL-10 has a protective role in experimental autoimmune uveoretinitis
14. Functional properties of interphotoreceptor retinoid-binding protein
15. Regulation of the interleukin (IL)-12R beta 2 subunit expression in developing T helper 1 (Th1) and Th2 cells
16. IGIF does not drive Th1 development but synergizes with IL-12 for interferon-gamma production and activates IRAK and NFkappaB
17. T lymphocyte differentiation in the periphery
18. Production of cytokines by mouse B cells: B lymphomas and normal B cells produce interleukin 10
19. TGF-b enhances macrophage ability to produce IL-10 in normal and tumor-bearing mice
20. Suppression of spontaneous uveoretinitis development by non-immunopathogenic peptide immunization
21. TH2 activated cells prevent experimental autoimmune uveoretinitis, a TH1-dependent autoimmune disease
22. Peptide-mediated suppression of experimental autoimmune uveoretinitis in mice: Development of a peptide vaccine