Role of tachykinin NK1 and NK2 receptors on colonic motility in anesthetized rats: Effect of agonists

Canadian Journal of Physiology and Pharmacology

Volumn 75, Issue 6, 1997, Pages 582-586

  Lecci, Alessandro ^a   Tramontana, Manuela ^a   Giuliani, Sandro ^a   Maggi, Carlo Alberto ^a  

^a Menarini Ricerche SpA   (Italy)

Author keywords

MEN 10627; MEN 11420; SR 140333; SR 48968; Tachykinin antagonists

Indexed keywords

MEN 10627; NEPADUTANT; NEUROKININ 1 RECEPTOR; NEUROKININ 2 RECEPTOR; NEUROKININ A [4-10][8 BETA ALANINE]; NOLPITANTIUM; SAREDUTANT; SUBSTANCE P DERIVATIVE; SUBSTANCE P SULFONE [9 SARCOSINE]; UNCLASSIFIED DRUG; BENZAMIDE DERIVATIVE; CYCLOPEPTIDE; DRUG DERIVATIVE; NEUROKININ A; NEUROKININ A (4 10), BETA ALA(8); NEUROKININ A (4-10), BETA-ALA(8)-; PEPTIDE FRAGMENT; PIPERIDINE DERIVATIVE; QUINUCLIDINE DERIVATIVE; SUBSTANCE P; SUBSTANCE P, SAR(9) MET(O2)(11); SUBSTANCE P, SAR(9)-MET(O2)(11)-;

ANESTHESIA; ANIMAL EXPERIMENT; BALLOON CATHETER; COLON MOTILITY; CONFERENCE PAPER; CONTROLLED STUDY; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; ANIMAL; ARTICLE; COLON; DRUG EFFECT; DRUG POTENTIATION; GASTROINTESTINAL MOTILITY; PHYSIOLOGY; ULTRASTRUCTURE; WISTAR RAT;

ANESTHESIA; ANIMALS; BENZAMIDES; COLON; GASTROINTESTINAL MOTILITY; MALE; NEUROKININ A; PEPTIDE FRAGMENTS; PEPTIDES, CYCLIC; PIPERIDINES; QUINUCLIDINES; RATS; RATS, WISTAR; RECEPTORS, NEUROKININ-1; RECEPTORS, NEUROKININ-2; SUBSTANCE P;

EID: 0030610613     PISSN: 00084212     EISSN: None     Source Type: Journal    
DOI: 10.1139/cjpp-75-6-582     Document Type: Conference Paper

References (28)

1. 8]neurokinin A(4-10). Aliment. Pharmacol. Ther. 8: 527-533.
2. Burcher, E., Buck, S.H., Lovemberg, W., and O'Donohue, T. 1986. Characterization and autoradiographic localization of multiple tachykinin binding sites in gastrointestinal tract and bladder. J. Pharmacol. Exp. Ther. 236: 819-831.
3. Chang, F.Y., Sharp, D., and Ouyang, A. 1991. Multiple neurokinin receptor subtypes are present in the colon of cat and rat. Ann. N.Y. Acad. Sci. 632: 374-376.
4. 2 receptors in rats. J. Pharm. Pharmacol. 46: 383-385.
5. Drapeau, G., D'Orleans-Juste, P., Dion, S., Rhaleb, N.E., Rouissi, N., and Regoli, D. 1987. Selective agonists for substance P and neurokinin receptors. Neuropeptides, 10: 43-54.
6. 2) receptor. Life Sci. 50: PL101-106.
7. Emonds-Alt, X., Doutremepuich, J.D., Heaulme, M., Neliat, G., Santucci, V., Steinberg, R., Vilain, P., Bichon, D., Ducoux, J.P., Van Broeck, D., Soubrie, P., Le Fur, G., and Breliere, J.C. 1993. In vitro and in vivo biological activities of SR 140,333, a novel potent nonpeptide tachykinin receptor antagonist. Eur. J. Pharmacol. 250: 403-413.
8. 1 and NK2 receptors in rat colonic hypersecretion induced by interleukin 1β: role of nitric oxide. Gastroenterology, 109: 483-489.
9. Furness, J.B., Young, H.M., Pompolo, S., Bornstein, J.C., Kunze, W.A.A., and McConalogue, K. 1995. Plurichemical transmission and chemical coding of neurons in the digestive tract. Gastroenterology, 108: 554-563.
10. 2 type of neurokinin receptor. J. Pharmacol. Exp. Ther. 246: 322-327.
11. Giuliani, S., Lecci, A., Giachetti, A., and Maggi, C.A. 1993. Tachykinins and reflexly-evoked atropine-resistant motility in the guinea-pig colon in vivo. J. Pharamacol. Exp. Ther. 265: 1224-1231.
12. Giuliani, S., Tramontana, M., Lecci, A., and Maggi, C.A. 1996. Tachykinin receptors mediate atropine-resistant rat duodenal reflex contractions in vivo. Naunyn-Schmiedebergs Arch. Pharmacol. 354: 327-335.
13. Hellstrom, P.M., Soder, O., and Theodorsson, E. 1991. Occurrence, release and effects of multiple tachykinins in cat colonic tissue and nerves. Gastroenterology, 100: 431-440.
14. ++ signaling pathways in intestinal muscle cells. J. Pharmacol. Exp. Ther. 270: 236-243.
15. Holzer-Petsche, U. 1995. Tachykinin receptors in gastrointestinal motility. Regul. Pept. 57: 19-42.
16. Khan, I., Lapierre, N., and Rangachari, P.K. 1995. Messenger RNAs for neurokinin and histamine receptor subtypes in isolated canine colonic crypts. J. Pharmacol. Exp. Ther. 272: 1285-1292.
17. 3 receptors in the hexamethonium-resistant inhibitory transmission in the rat colon. Naunyn-Schmiedebergs Arch. Pharmacol. 353: 671-679.
18. 2 receptors in producing fast and slow atropine-resistant neurotransmission to the circular muscle of the guinea-pig colon. Neuroscience, 63: 1137-1152.
19. 2 receptor. J. Pharmacol. Exp. Ther. 271: 1489-1500.
20. Parsons, A.M., Seybold, V.S., Chandan, R., Vogt, J., Larson, A.A., Murray, C.R., Soldani, G., and Brown, D.R. 1992. Neurokinin receptors and mucosal ion transport in porcine jejunum. J. Pharmacol. Exp. Ther. 261: 1213-1221.
21. Portbury, A.L., Furness, J.B., Young, H.M., Southwell, B.R., and Vigna, S.R. 1996. Localization of NK1 receptor immunoreactivity to neurons and interstitial cells of the guinea-pig gastrointestinal tract. J. Comp. Neurol. 367: 342-351.
22. Regoli, D., Nguyen, Q.T., and Calò, G. 1996. Pharamacology of tachykinins. In Neurogenic inflammation. Edited by P. Geppetti and P. Holzer. CRC Press, Boca Raton, Fla. pp. 91-99.
23. Rovero, P., Pestellini, V., Patacchini, R., Giuliani, S., Santicioli, P., Maggi, C.A., Meli, A., and Giachetti, A. 1989. A potent and selective agonist for NK2 tachykinin receptors. Peptides, 10: 593-595.
24. Scheurer, U., Drack, E., and Halter, F. 1994. Substance P activates rat colonic motility via excitatory and inhibitory neuronal pathways and direct action on muscles. J. Pharmacol. Exp. Ther. 271: 7-13.
25. Shuttleworth, C.W.R., and Keef, K.D. 1995. Roles of peptides in entereic neuromuscolar transmission. Regul. Pept. 56: 101-120.
26. Sternini, C., Anderson, K., Frantz, G., Krause, J.E., and Brecha, N.S. 1989. Expression of SP/NKA-encoding preprotachykinin messenger RNA in rat enteric nervous system. Gastroenterology, 97: 348-356.
27. Sternini, C., Su, D., Gamp, P.D., and Bunnett, N.W. 1995. Cellular sites of expression of the neurokinin-1 receptor in the rat gastrointestinal tract. J. Comp. Neurol. 358: 531-540.
28. 2 receptor selective antagonist MEN 10,627 in rat small intestine. Jpn. J. Pharmacol. 65: 281-283.