Functional role of TGFβ in Alzheimer's disease microvascular injury: Lessons from transgenic mice

Neurochemistry International

Volumn 39, Issue 5-6, 2001, Pages 393-400

  Masliah, Eliezer ^a,b   Ho, Gilbert ^a   Wyss Coray, Tony ^c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Alzheimer's Disease; Microvascular injury; Transforming growth factor ; Transgenic mice

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; IBUPROFEN; ISOPROTEIN; TRANSFORMING GROWTH FACTOR BETA; VACCINE;

ALZHEIMER DISEASE; AMYLOIDOSIS; BRAIN BLOOD VESSEL; CEREBROVASCULAR ACCIDENT; MACROGLIA; MICROGLIA; MICROVASCULATURE; NERVE CELL NECROSIS; NEUROPATHOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN SYNTHESIS; REVIEW; SENILE PLAQUE; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE;

EID: 0034802221     PISSN: 01970186     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0197-0186(01)00046-8     Document Type: Article

References (62)

1. Inflammation and Alzheimer's disease
2. TGF-β, regulation of Alzheimer amyloid precursor protein mRNA expression in a normal human astrocyte cell line: mRNA stabilization
3. Expression of various TGF-β isoforms and type I receptor in necrotizing human brain lesions
4. Cytokine actions in the central nervous system
5. Expression of TGF-β type II receptor in the CNS
6. Effects of transforming growth factor-beta on murine astrocyte glutamine synthetase activity. Implication in neuronal injury
7. Serum cytokine levels in patients with Alzheimer's disease
8. Glial cell-specific mechanisms of TGF-β1 induction by IL-1 in cerebral cortex
9. Neuropathological changes caused by hydrocephalus
10. Disorders of the extracellular matrix and the pathogenesis of senile dementia of the Alzheimer's type
11. TGF-beta 1 is an organizer of responses to neurodegeneration
12. Altered expression of transforming growth factor-β in Alzheimer's disease
13. Transforming growth factor-βS in neurodegenerative disease
14. Rodent models of Alzheimer's disease: Rat Aβ infusion approaches to amyloid deposits
15. Overexpression of TGF-β1 in the central nervous system of transgenic mice results in hydrocephalus
16. Genetic control of the circulating concentration of transforming growth factor type β1
17. Regulation of β-amyloid precursor protein isoform mRNAs by transforming growth factor-β1 and interleukin-1 in astrocytes
18. Cerebral amyloid angiopathy. Prospects for clinical diagnosis and treatment
19. Effects of transforming growth factor-β (Isoforms 1-3) on amyloid-β deposition, inflammation, and cell targeting in organotypic hippocampal slice cultures
20. TGF-β signalling from cell membrane to nucleus through SMAD proteins
21. Transforming growth factor-β stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix
22. Proteoglycans and other basement membrane proteins in amyloidoses
23. Differential neuronal and astrocytic expression of transforming growth factor beta isoforms in rat hippocampus following transient forebrain ischemia
24. Increased expression of TGF-βl in brain tissue after ischemic stroke in humans
25. Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death
26. Proteoglycans and the acute-phase response in Alzheimer's disease brain
27. Transforming growth factor-β1 in the rat brain: Increase after injury and inhibition of astrocyte proliferation
28. Lewy bodies contain altered alpha-synuclein in brains of many familial Alzheimer's disease patients with mutations in presenilin and amyloid precursor protein genes
29. Enhanced expression of transforming growth factor β1 in the rat brain after a localised cerebral injury
30. Effects of transforming growth factor beta I on scar production in the injured central nervous system of the rat
31. Analysis of genetic polymorphisms in the transforming growth factor-β1 gene and the risk of Alzheimer's disease
32. Cytokine gene expression as a function of the clinical progression of Alzheimer disease dementia
33. Transgenic animal models of Alzheimer disease
34. TGF-β signal transduction
35. Cellular signaling roles of TGFβ, TNFα and βAPP in brain injury responses and Alzheimer's disease
36. Protection of transforming growth factor-beta I activity by heparin and fucoidan
37. The inflammatory response system of brain. Implications for therapy of Alzheimer and other neurodegenerative diseases
38. Transforming growth factor β mediates increase of mature transmembrane amyloid precursor protein in microglial cells
39. TGF-β1 mRNA increases in macrophage/microglial cells of the hippocampus in response to deafferentation and kainic acid-induced neurodegeneration
40. Latent transforming growth factor-β: Structural features and mechanisms of activation
41. Hypoxic effects on glutamate uptake in cultured glial cells
42. Transforming growth factor β1 and fibronectin messenger RNA in rat brain: Responses to injury and cell-type localization
43. Differential expression of TGF-β1, 2 and 3 isotypes in Alzheimer's disease: A comparative immunohistochemical study with cerebral infarction, aged human and mouse control brains
44. Protective effect of transforming growth factor β1 on β-amyloid neurotoxicity in rat hippocampal neurons
45. Differential effects of transforming growth factor-βS and glial cell line-derived neurotrophic factor on gene expression of presenilin-1 in human post-mitotic neurons and astrocytes
46. Transforming growth factor-β
47. Transforming growth factor type β: Rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro
48. Inflammation and Alzheimer's disease pathogenesis
49. Alzheimer's disease after remote head injury: An incidence study
50. Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease
51. Expression of mRNAs coding for the transforming growth factor-β receptors in brain regions of euthyroid and hypothyroid neonatal rats and in adult brain
52. Oral administration of cholera toxin B subunit conjugated to myelin basic protein protects against experimental autoimmune encephalomyelitis by inducing transforming growth factor-beta-secreting cells and suppressing chemokine expression
53. Transforming growth factor beta isoforms in the adult rat central and peripheral nervous system
54. Transforming growth factor-β1 is in plaques in Alzheimer and Down pathologies
55. Transforming growth factor-β1 inhibits the proliferation of rat astrocytes induced by serum and growth factors
56. Restricted expression of type-II TGFβ receptor in murine embryonic development suggests a central role in tissue modeling and CNS patterning
57. Transforming growth factor beta isoform 2-specific high affinity binding to native alpha 2-macroglobulin. Chimeras identify a sequence that determines affinity for native but not activated alpha 2-macroglobulin
58. Ibuprofen, inflammation and Alzheimer disease
59. Increased central nervous system production of extracellular matrix components and development of hydrocephalus in transgenic mice overexpressing transforming growth factor β1
60. Amyloidogenic role of transforming growth factor β1 in transgenic mice and Alzheimer's disease
61. TGF-β1 modulates brain amyloid deposition and induces Alzheimer's disease like microvascular abnormalities in transgenic mice
62. Chronic overproduction of transforming growth factor-β1 by astrocytes promotes Alzheimer's disease-like microvascular degeneration in transgenic mice