Cerebral amyloid angiopathy: Prospects for clinical diagnosis and treatment

Neurology

Volumn 51, Issue 3, 1998, Pages 690-694

  Greenberg, Steven M ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; ANTIINFLAMMATORY AGENT; ANTIOXIDANT; APOLIPOPROTEIN E2;

ALLELE; BRAIN BIOPSY; BRAIN BLOOD VESSEL; BRAIN HEMORRHAGE; EXTRACELLULAR MATRIX; FIBRINOLYSIS; HUMAN; HUMAN TISSUE; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; REVIEW; VASCULAR AMYLOIDOSIS; VASCULAR ENDOTHELIUM;

EID: 0031751312     PISSN: 00283878     EISSN: None     Source Type: Journal    
DOI: 10.1212/WNL.51.3.690     Document Type: Review

References (50)

1. Mandybur TI. Cerebral amyloid angiopathy: the vascular pathology and complications. J Neuropathol Exp Neurol 1986;45: 79-90.
2. Vonsattel JP, Myers RH, Hedley-Whyte ET, Ropper AH, Bird ED, Richardson EP. Cerebral amyloid angiopathy without and with cerebral hemorrhages: a comparative histological study. Ann Neurol 1991;30:637-649.
3. Greenberg SM, Vonsattel JP, Stakes JW, Gruber M, Finklestein SP. The clinical spectrum of cerebral amyloid angiopathy: presentations without lobar hemorrhage. Neurology 1993;43:2073-2079.
4. Schutz H, Bodeker RH, Damian M, Krack P, Dorndorf W. Age-related spontaneous intracerebral hematoma in a German community. Stroke 1990;21:1412-1418.
5. Broderick J, Brott T, Tomsick T, Leach A. Lobar hemorrhage in the elderly. The undiminishing importance of hypertension. Stroke 1993;24:49-51.
6. Greenberg SM, Vonsattel J-PG. Diagnosis of cerebral amyloid angiopathy. Sensitivity and specificity of cortical biopsy. Stroke 1997;28:1418-1422.
7. Ellis RJ, Olichney JM, Thai LJ, et al. Cerebral amyloid angiopathy in the brains of patients with Alzheimer's disease: the CERAD experience, Part XV. Neurology 1996;46:1592-1596.
8. Sloan MA, Price TR, Petito CK, et al. Clinical features and pathogenesis of intracerebral hemorrhage after rt-PA and heparin therapy for acute myocardial infarction: The Thrombolysis in Myocardial Infarction (TIMI) II Pilot and Randomized Clinical Trial combined experience. Neurology 1995;45: 649-658.
9. Van Nostrand WE, Wagner SL, Haan J, Bakker E, Roos RA. Alzheimer's disease and hereditary cerebral hemorrhage with amyloidosis-Dutch type share a decrease in cerebrospinal fluid levels of amyloid beta-protein precursor. Ann Neurol 1992;32: 215-218.
10. Pirttila T, Mehta PD, Soininen H, et al. Cerebrospinal fluid concentrations of soluble amyloid beta-protein and apolipoprotein E in patients with Alzheimer's disease: correlations with amyloid load in the brain. Arch Neurol 1996;53:189-193.
11. Scheuner D, Eckman C, Jensen M, et al. Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. Nat Med 1996;2:864-870.
12. Tamaoka A, Fukushima T, Sawamura N, et al. Amyloid beta protein in plasma from patients with sporadic Alzheimer's disease. J Neurol Sci 1996;141:65-68.
13. Levy E, Carman MD, Fernandez Madrid IJ, et al. Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type. Science 1990;248:1124-1126.
14. Hendriks L, van Duijn CM, Cras P, et al. Presenile dementia and cerebral haemorrhage linked to a mutation at codon 692 of the beta-amyloid precursor protein gene. Nat Genet 1992;1: 218-221.
15. Palsdottir A, Abrahamson M, Thorsteinsson L, et al. Mutation in cystatin C gene causes hereditary brain haemorrhage. Lancet 1988;2:603-604.
16. Graffagnino C, Herbstreith MH, Schmechel DE, Levy E, Roses AD, Alberts MJ. Cystatin C mutation in an elderly man with sporadic amyloid angiopathy and intracerebral hemorrhage. Stroke 1995;26:2190-2193.
17. Graffagnino C, Herbstreith MH, Roses AD, Alberts MJ. A molecular genetic study of intracerebral hemorrhage. Arch Neurol 1994;51:981-984.
18. Anders KH, Wang ZZ, Kornfeld M, et al. Giant cell arteritis in association with cerebral amyloid angiopathy: immunohistochemical and molecular studies. Hum Pathol 1997;28:1237-1246.
19. Corder EH, Saunders AM, Strittmatter WJ, et al. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science 1993;261:921-923.
20. Corder EH, Saunders AM, Risch NJ, et al. Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease. Nat Genet 1994;7:180-184.
21. Nicoll JA, Burnett C, Love S, et al. High frequency of apolipoprotein E epsilon 2 allele in hemorrhage due to cerebral amyloid angiopathy. Ann Neurol 1997;41:716-721.
22. Greenberg SM, Rebeck GW, Vonsattel JPV, Gomez-Isla T, Hyman BT. Apolipoprotein E ε4 and cerebral hemorrhage associated with amyloid angiopathy. Ann Neurol 1995;38:254-259.
23. Premkumar DR, Cohen DL, Hedera P, Friedland RP, Kalaria RN. Apolipoprotein E-epsilon 4 alleles in cerebral amyloid angiopathy and cerebrovascular pathology associated with Alzheimer's disease. Am J Pathol 1996;148:2083-2095.
24. Greenberg SM, Vonsattel J-PG, Segal AZ, et al. Association of apolipoprotein E ε2 and vasculopathy in cerebral amyloid angiopathy. Neurology 1998;50:961-965.
25. Mahley RW. Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. Science 1988;240:622-630.
26. Fountain NB, Eberhard DA. Primary angiitis of the central nervous system associated with cerebral amyloid angiopathy: report of two cases and review of the literature. Neurology 1996;46:190-197.
27. 123I-labeled serum amyloid P component. N Engl J Med 1990;323:508-513.
28. 125I]A beta 1-40 labels amyloid deposits in the aged primate brain in vivo. Neuroreport 1996;7:2607-2611.
29. Walker LC, Price DL, Voytko ML, Schenk DB. Labeling of cerebral amyloid in vivo with a monoclonal antibody. J Neuropathol Exp Neurol 1994;53:377-383.
30. Friedland RP, Kalaria R, Berridge M, et al. Neuroimaging of vessel amyloid in Alzheimer's disease. Ann NY Acad Sci 1997; 826:242-247.
31. Vinters HV. Cerebral amyloid angiopathy. A critical review. Stroke 1987;18:311-324.
32. Kase CS. Cerebral amyloid angiopathy. In: Kase CS, Caplan LR, eds. Intracerebral hemorrhage. Boston: Butterworth-Heinemann, 1994:179-200.
33. Greenberg SM, Finklestein SP, Schaefer PW. Petechial hemorrhages accompanying lobar hemorrhages: detection by gradient-echo MRI. Neurology 1996;46:1751-1754.
34. Greenberg SM, O'Donnell HC, Schaefer PW. Emergence of new hemorrhages in cerebral amyloid angiopathy: serial gradient-echo MRI as a marker of clinically silent disease progression. Neurology 1998;50:A442. Abstract.
35. Brott T, Broderick J, Kothari R, et al. Early hemorrhage growth in patients with intracerebral hemorrhage. Stroke 1997;28:1-5.
36. Kase CS. Lobar hemorrhage. In: Kase CS, Caplan LR, eds. Intracerebral hemorrhage. Boston: Butterworth-Heinemann, 1994:363-382.
37. Passero S, Burgalassi L, D'Andrea P, Battistini N. Recurrence of bleeding in patients with primary intracerebral hemorrhage. Stroke 1995;26:1189-1192.
38. Hart RG, Boop BS, Anderson DC. Oral anticoagulants and intracranial hemorrhage. Stroke 1995;26:1471-1477.
39. Alonzo NC, Hyman BT, Rebeck GW, Greenberg SM. Progression of cerebral amyloid angiopathy. Accumulation of amyloid-ß40 in already affected vessels. J Neuropathol Exp Neurol 1998;57:353-359.
40. Verbeek MM, Eikelenboom P, de Waal RM. Differences between the pathogenesis of senile plaques and congophilic angiopathy in Alzheimer disease. J Neuropathol Exp Neurol 1997;56:751-761.
41. Bales KR, Verina T, Dodel RC, et al. Lack of apolipoprotein E dramatically reduces amyloid beta-peptide deposition. Nat Genet 1997;17:263-264.
42. Wyss-Coray T, Masliah E, Mallory M, et al. Amyloidogenic role of cytokine TGF-ß1 in transgenic mice and in Alzheimer's disease. Nature 1997;389:603-606.
43. Wyss-Coray T, Feng L, Masliah E, et al. Increased central nervous system production of extracellular matrix components and development of hydrocephalus in transgenic mice overexpressing transforming growth factor-beta 1. Am J Pathol 1995;147:53-67.
44. Davis-Salinas J, Van Nostrand WE. Amyloid beta-protein aggregation nullifies its pathologic properties in cultured cerebrovascular smooth muscle cells. J Biol Chem 1995;270: 20887-20890.
45. Thomas T, Thomas G, McLendon C, Sutton T, Mullan M. ß-Amyloid-mediated vasoactivity and vascular endothelial damage. Nature 1996;380:168-171.
46. Behl C, Davis JB, Lesley R, Schubert D. Hydrogen peroxide mediates amyloid beta protein toxicity. Cell 1994;77:817-827.
47. Sano M, Ernesto C, Thomas RG, et al. A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's Disease Cooperative Study. N Engl J Med 1997;336:1216-1222.
48. Yamada M, Itoh Y, Shintaku M, et al. Immune reactions associated with cerebral amyloid angiopathy. Stroke 1996;27: 1155-1162.
49. Maat-Schieman ML, van Duinen SG, Rozemuller AJ, Haan J, Roos RA. Association of vascular amyloid beta and cells of the mononuclear phagocyte system in hereditary cerebral hemorrhage with amyloidosis (Dutch) and Alzheimer disease. J Neuropathol Exp Neurol 1997;56:273-284.
50. Uchihara T, Akiyama H, Kondo H, Ikeda K. Activated microglial cells are colocalized with perivascular deposits of amyloid-beta protein in Alzheimer's disease brain. Stroke 1997;28:1948-1950.