Epigenetic regulation of the KAI1 metastasis suppressor gene in human prostate cancer cell lines

Japanese Journal of Cancer Research

Volumn 92, Issue 9, 2001, Pages 947-951

  Sekita, Nobuyuki ^a   Suzuki, Hiroyoshi ^a   Ichikawa, Tomohiko ^a   Kito, Hiroki ^a   Akakura, Koichiro ^a   Igarashi, Tatsuo ^a   Nakayama, Tsuyoshi ^b   Watanabe, Masatoshi ^b   Shiraishi, Taizo ^b   Toyota, Minoru ^c   Yoshie, Osamu ^d   Ito, Haruo ^a  

^a CHIBA UNIVERSITY   (Japan)

^b MIE UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c SAPPORO MEDICAL UNIVERSITY   (Japan)

^d KINKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Histone deacetylation; KAI1; Metastasis suppressor gene; Methylation; Prostate cancer

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; BISULFITE; CYTOSINE; DNA; GUANINE; HISTONE DEACETYLASE INHIBITOR; MESSENGER RNA; RESTRICTION ENDONUCLEASE; TRICHOSTATIN A;

ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; CPG ISLAND; DEMETHYLATION; DNA FLANKING REGION; DNA METHYLATION; DNA MODIFICATION; DOWN REGULATION; GENE AMPLIFICATION; GENE EXPRESSION; GENE SEQUENCE; GENETIC REGULATION; HUMAN; HUMAN CELL; METASTASIS; NORTHERN BLOTTING; PRIORITY JOURNAL; PROMOTER REGION; PROSTATE CANCER; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SUPPRESSOR GENE; TRANSCRIPTION REGULATION;

ADENOCARCINOMA; ANTIGENS, CD; AZACITIDINE; BASE SEQUENCE; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; DNA METHYLATION; ENZYME INHIBITORS; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE SILENCING; GENES, TUMOR SUPPRESSOR; HISTONE DEACETYLASES; HUMANS; HYDROXAMIC ACIDS; KANGAI-1 PROTEIN; MALE; MEMBRANE GLYCOPROTEINS; MOLECULAR SEQUENCE DATA; NEOPLASM METASTASIS; NEOPLASM PROTEINS; POLYMERASE CHAIN REACTION; PROMOTER REGIONS (GENETICS); PROSTATIC HYPERPLASIA; PROSTATIC NEOPLASMS; PROTO-ONCOGENE PROTEINS; SULFITES; TUMOR CELLS, CULTURED;

EID: 0034796983     PISSN: 09105050     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1349-7006.2001.tb01185.x     Document Type: Article

References (23)

1. KAI1, a metastasis suppressor gene for prostate cancer on human chromosome 11p11.2
2. KAI1, a putative marker for metastatic potential in human breast cancer
3. Correlation of KAI1/CD82 gene expression with good prognosis in patients with non-small cell lung cancer
4. Loss of KAI1 messenger RNA expression in both high grade and invasive bladder cancers
5. Down-regulation of the KAI1 metastasis suppressor gene during the progression of human prostatic cancer infrequently involves gene mutation or allelic loss
6. Relationships between chromatin organization and DNA methylation in determining gene expression
7. DNA methylation
8. Silencing of the VHL tumor-suppressor gene by methylation in renal cell carcinoma
9. 5′ CpG island methylation is associated with transcriptional silencing of the tumor suppressor p16/CDKN2/MTS1 in human cancers
10. E-Cadherin expression is silenced by DNA hypermethylation in human breast and prostate carcinomas
11. Epigenetic regulation of androgen receptor gene expression in human prostate cancers
12. Methylation-specific PCR: A novel PCR assay for methylation status of CpG islands
13. Reaction of sodium bisulfite with uracil, cytosine, and their derivatives
14. The LNCaP cell line-a new model for studies on human prostatic carcinoma
15. Establishment and characterization of a human prostatic carcinoma cell line (PC-3)
16. Heterotransplantation of a human prostatic adenocarcinoma cell line in nude mice
17. Chromosomal analysis of human prostatic adenocarcinoma cell lines
18. Establishment of a new prostatic carcinoma cell line (TSU-Pr1)
19. Genomic organization of the human KAI1 metastasis-suppressor gene
20. Expression of KAI1 protein in benign prostatic hyperplasia and prostate cancer
21. Identification of the rat homologue of KAI1 and its expression in Dunning rat prostate cancers
22. Methylation of a CpG island within the promoter region of the KAI1 metastasis suppressor gene is not responsible for down-regulation of KAI1 expression in invasive bladder cancers or cancer cell lines
23. The expression of the KAI1 gene, a tumor metastasis suppressor, is directly activated by p53