Methylation of a CpG island within the promoter region of the KAI1 metastasis suppressor gene is not responsible for down-regulation of KAI1 expression in invasive cancers or cancer cell lines

Cancer Letters

Volumn 157, Issue 2, 2000, Pages 169-176

  Jackson, Paul ^a,b   Millar, Douglas ^c   Kingsley, Elizabeth ^a,b   Yardley, Gina ^a,b   Ow, Kim ^a,b   Clark, Susan ^c   Russell, Pamela J ^a,b  

^a Oncology Research Centre   (Australia)

^b UNIVERSITY OF NEW SOUTH WALES   (Australia)

^c CSIRO   (Australia)

Author keywords

Bladder; Invasion; KAI1; Metastasis suppressor; Methylation

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; DNA; MESSENGER RNA;

ARTICLE; BLADDER CARCINOGENESIS; CANCER INHIBITION; CONTROLLED STUDY; CPG ISLAND; DNA DETERMINATION; GENE ACTIVATION; GENE EXPRESSION; GENETIC CODE; HUMAN; HUMAN CELL; IN SITU HYBRIDIZATION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN METHYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR SUPPRESSOR GENE;

ANTIGENS, CD; ANTIMETABOLITES, ANTINEOPLASTIC; AZACITIDINE; BASE SEQUENCE; CARCINOMA, TRANSITIONAL CELL; CPG ISLANDS; DOWN-REGULATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IN SITU HYBRIDIZATION; KANGAI-1 PROTEIN; MEMBRANE GLYCOPROTEINS; METHYLATION; MOLECULAR SEQUENCE DATA; NEOPLASM INVASIVENESS; PROMOTER REGIONS (GENETICS); PROTO-ONCOGENE PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TUMOR CELLS, CULTURED; URINARY BLADDER NEOPLASMS;

EID: 0034285094     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3835(00)00483-3     Document Type: Article

References (24)

1. Dong J.T., Lamb P.W., Rinker-Schaeffer C.W., Vukanovic J., Ichikawa T., Isaacs J.T., Barrett J.C. KAI1, a metastasis suppressor gene for prostate cancer on human chromosome 11p11.2, Science. 268:1995;884-886.
2. Ueda T., Ichikawa T., Tamru J., Mikata A., Akakura K., Akimoto S., Imai T., Yoshie O., Shirashi T., Yayani R., Ito H., Shimazaki J. Expression of the KAI1 protein in benign prostatic hyperplasia and prostate cancer. Am. J. Pathol. 149:1996;1435-1440.
3. Adachi M., Taki T., Ieki Y., Huang C.I., Higashiyama M., Miyake M. Correlation of KAI1/CD82 gene expression with good prognosis in patients with non-small cell lung cancer. Cancer Res. 56:1996;1751-1755.
4. Lombardi D.P., Geradts J., Foley J.F., Chiao C., Lamb P.W., Barrett J.C. Loss of KAI1 expression in the progression of colorectal cancer. Cancer Res. 59:1999;5724-5731.
5. Friess H., Guo X.Z., Berberat P., Graber H.U., Zimmermann A., Korc M., Buchler M.W. Reduced KAI1 expression in pancreatic cancer is associated with lymph nodes and distant metastases. Int. J. Cancer. 79:1998;349-355.
6. Guo X.Z., Friess H., Di F.F. Mola, J.M. Heinicke, M. Abou-Shady, H.U. Graber, H.U. Baer, A. Zimmermann, M. Korc, M.W. Buchler, KAI1, a new metastasis suppressor gene, is reduced in metastatic hepatocellular carcinoma, Hepatology. 28:1998;1481-1488.
7. Yu Y., Yang J.L., Marcovic B., Jackson P., Yardley G., Barrett J., Russell P.J. Loss of KAI1 messenger RNA expression in both high grade and invasive bladder cancers. Clin. Cancer Res. 3:1997;1045-1049.
8. Ow K., Delprado W., Fisher R., Barrett J., Yu Y., Jackson P., Russell P.J. Relationship between expression of the KAI1 metastasis suppressor and other markers of advanced bladder cancer. J. Pathol. 191:2000;39-47.
9. Dong J.T., Suzuki H., Pin S.S., Bova G.S., Schalken J.A., Isaacs W.B., Barrett J.C., Isaacs J.T. Down-regulation of the KAI1 metastasis gene during the progression of human prostatic cancer infrequently involves gene mutation or allelic loss. Cancer Res. 56:1996;4387-4390.
10. Tagawa K., Arihiro K., Takeshima E., Hiyama M., Yamasaki K. Down-regulation of KAI1 messenger RNA expression is not associated with loss of heterozygosity of the KAI1 gene region in lung adenocarcinoma. Jpn. J. Cancer. 90:1999;970-976.
11. Mashimo T., Watabe M., Hirota S., Hosobe S., Miura K., Tegtmeyer P.J., Rinker-Schaeffer C.W., Watabe K. The expression of the KAI1 gene, a metastasis suppressor, is directly activated by p53, Proc. Natl. Acad. Sci. USA. 95:1998;11307-11311.
12. Stirzaker C., Millar D.S., Paul C.S., Warnecke P.M., Davison J., Vincent P.C., Frommer M., Clark S.J. Extensive DNA methylation spanning the Rb promoter in retinoblastoma tumours. Cancer Res. 57:1997;2229-2237.
13. Baylin S.B., Herman J.G., Graff J.R., Vertino P.M., Issa J.P. Alterations in DNA methylation: a fundamental aspect of neoplasia. Adv. Cancer Res. 72:1999;141-196.
14. Melki J.R., Vincent P.C., Clark S.J. Concurrent DNA hypermethylation of multiple genes in acute myeloid leukemia. Cancer Res. 59:1999;3730-3740.
15. Millar D.S., Ow K.K., Paul C.S., Russell P.J., Molloy P.J., Clark S.J. Detailed methylation analysis of the GST-P1 gene in prostate cancer. Oncogene. 18:1999;1313-1324.
16. Dong J.T., Isaacs W.B., Barrett J.C., Isaacs J.T. Genomic organization of the human KAI1 metastasis-suppressor gene. Genomics. 41:1997;25-32.
17. Gardiner-Garden M., Frommer M. CpG islands in vertebrate genomes. J. Mol. Biol. 196:1987;261-282.
18. Brown J.L., Russell P.J., Phillips J., Wotherspoon J., Raghavan D. Clonal analysis of a bladder cancer cell lines: an experimental model of tumor heterogeneity. Br. J. Cancer. 61:1990;369-376.
19. Russell P.J., Wass J., Lukeis R., Garson O.M., Jelbart M., Wills E., Phillips J., Brown J., Carrington N., Vincent P.C., Raghavan D. Characterization of cell lines derived from a multiply aneuploid human bladder cancer. Int. J. Cancer. 44:1989;276-285.
20. Clark S.J., Harrison J., Paul C.S., Frommer M.I. High sensitivity mapping of methylated cytosines. Nucleic Acids Res. 22:1994;2990-2997.
21. Warnecke P.M., Stirzaker C., Melki J.R., Miller D.S., Paul C.S., Clark S.J. Detection and measurement of PCR strand bias in quantitative methylation analysis of bisulphite-treated DNA. Nucleic Acids Res. 25:1997;4422-4426.
22. Bender C.M., Pao M.M., Jones P.A. Inhibition of DNA methylation by 5-aza-2-deoxy-cytidine suppresses the growth of human tumour cell lines. Cancer Res. 58:1998;95-101.
23. Herman J.G., Graff J.R., Myohanen S., Nelkin B.D., Baylin S.B. Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands. Proc Natl. Acad. Sci. USA. 93:1996;9821-9828.
24. Jackson P., Kingsley E., Russell P.J. Inverse correlation between KAI1 mRNA levels and invasive behaviour in bladder cancer cell lines. Cancer Lett. 156:2000;9-17.