Homozygous and frequent deletion of proximal 8p sequences in human prostate cancers: Identification of a potential tumor suppressor gene site

Genes Chromosomes and Cancer

Volumn 23, Issue 3, 1998, Pages 255-262

  Prasad, Madhu A ^a   Trybus, Tanya M ^a   Wojno, Kirk J ^a,b   Macoska, Jill A ^a,b  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CARCINOGENESIS; FLUORESCENCE IN SITU HYBRIDIZATION; GENE DELETION; GENE MAPPING; GENE SEQUENCE; HUMAN; HUMAN TISSUE; PATHOGENESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROSTATE CANCER; SEQUENCE ANALYSIS; TUMOR SUPPRESSOR GENE;

ADULT; AGED; CHROMOSOME DELETION; CHROMOSOMES, HUMAN, PAIR 8; GENES, TUMOR SUPPRESSOR; GENETIC MARKERS; HUMANS; LOSS OF HETEROZYGOSITY; MALE; MIDDLE AGED; POLYMERASE CHAIN REACTION; PROSTATE-SPECIFIC ANTIGEN; PROSTATIC NEOPLASMS; TUMOR MARKERS, BIOLOGICAL;

EID: 0031719451     PISSN: 10452257     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2264(199811)23:3<255::AID-GCC8>3.0.CO;2-0     Document Type: Article

References (25)

1. Bergerheim USR, Kunimi K, Collins VP, Ekman P (1993) Deletion mapping of chromosomes 8, 10 and 16 in human prostatic carcinoma. Genes Chromosomes Cancer 3:215-220.
2. Bova GS, Carter BS, Bussemakers JG, Emi M, Fujiwara Y, Kyprianou N, Jacobs SC, Robinson JC, Epstein JI, Walsh PC, Isaacs WB (1993) Homozygous deletion and frequent allelic loss of chromosome 8p22 loci in human prostate cancer. Cancer Res 53:3869-3873.
3. Bova GS, MacGrogan D, Levy A, Pin SS, Bookstein R, Isaacs WB (1996) Physical mapping of chromosome 8p22 markers and their homozygous deletion in a metastatic prostate cancer. Genomics 35:46-54.
4. Crundwell MC, Chughtai S, Knowles M, Takle L, Lutscombe M, Neoptolemos JP, Morton DG, Phillips SMA (1996) Allelic loss on chromosomes 8p, 22q, and 18q (DCC) in human prostate cancer. Int J Cancer 69:295-300.
5. Farrington SM, Cunningham C, Boyle SM, Wyllie AH, Dunlop MG (1996) Detailed physical and deletion mapping of 8p with isolation of YAC clones from tumour suppresor loci involved in colorectal cancer. Oncogene 12:1803-1808.
6. Fujiwara H, Ohata H, Kuroki T, Koyama K, Tsuchiya E, Monden M, Nakamura Y (1995) Isolation of a candidate tumor suppressor gene on chromosome 8p21.3-p22 that is homologous to an extracellular domain of the PDGF receptor beta gene. Oncogene 10:891-895.
7. Hahn SA, Schutte M, Shamsul Hoque ATM, Moskaluk CA, daCosta LT, Rozenblum F, Weinstein CL, Fischer A, Yeo CJ, Hruban RH, Kern SE (1996) DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1. Science 271:350-353.
8. Jenkins RB, Qian J, Lieber MM, Bostwick DG (1997) Detection of c-myc oncogene amplification and chromosomal anomalies in metastatic prostatic carcinoma by fluorescence in situ hybridization. Cancer Res 57:524-531.
9. Kagan J, Stein J, Babaian RJ, Joe YS, Pisters LL, Glassman AB, von Eschenbach AC, Troncoso P (1995) Homozygous deletions at 8p22 and 8p21 in prostate cancer implicate these regions as the sites for candidate tumor suppressor genes. Oncogene 11:2121-2126.
10. Li J, Yen C, Liaw D, Podsypanina K, Bose S, Wang SI, Puc J, Milaresis C, Rodgers L, McCombie R, Bigner SH, Giovanelli BC, Ittmann M, Tycko B, Hibshoosh H, Wigler MH, Parsons R (1997) PTEN, a putative tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science 275:1943-1947.
11. MacGrogan D, Levy A, Bostwick D, Wagner M, Wells D, Bookstein R (1994) Loss of chromosome arm 8p loci in prostate cancer: Mapping by quantitative allelic imbalance. Genes Chromosomes Cancer 10:151-159.
12. Macoska JA, Micale MA, Sakr WA, Benson PD, Wolman SR (1993) Extensive genetic alterations in prostate cancer revealed by dual PCR and FISH analysis. Genes Chromosomes Cancer 8:88-97.
13. Macoska JA, Trybus TM, Sakr WA, Wolf MC, Benson PD, Powell IJ, Pontes JE (1994) Fluorescence in situ hybridization (FISH) analysis of 8p allelic loss and chromosome 8 instability in human prostate cancer. Cancer Res 54:3824-3830.
14. Macoska JA, Trybus TM, Benson PD, Sakr WA, Grignon DJ, Wojno KD, Pietruk T, Powell IJ (1995) Evidence for three tumor supressor gene loci on chromosome 8p in human prostate cancer. Cancer Res 55:5390-5395.
15. Nihei N, Ichikawa T, Kawana Y, Kuramochi H, Kugoh H, Oshimura M, Hayata I, Shimazaki J, Ito H (1996) Mapping of metastasis suppressor gene(s) for rat prostate cancer on the short arm of human chromosome 8 by irradiated microcell-mediated transfer. Genes Chromosomes Cancer 17:260-268.
16. Sakr WA, Macoska JA, Benson PD, Grignon DJ, Wolman SR, Pontes JE, Crissman JD (1994) Allelic loss in locally mctastatic, multisampled prostate cancer. Cancer Res 54:3273-3277.
17. Suzuki H, Emi M, Komiya A, Fujiwara Y, Yatani R, Nakamura Y, Shimazaki J (1995) Localization of a tumor suppressor gene associated with progression of human prostate cancer within a 1.2 Mb region of 8p22-21.3. Genes Chromosomes Cancer 13:168-174.
18. Takle LA, Knowles MA (1996) Deletion mapping implicates two tumor suppressor genes on chromosome 8p in the development of bladder cancer. Oncogene 12:1083-1087.
19. Trapman J, Sleddens HFBM, van der Weiden MM, Dinjens WNM, Konig JJ, Schroder FH, Faber PW, Bosnian FT (1994) Loss of heterozygosity of chromosome 8 microsatellite loci implicates a candidate tumor suppressor gene between the loci D8S87 and D8S133 in human prostate cancer. Cancer Res 54:6061-6064.
20. Trybus TM, Burgess AC, Wojno KJ, Glover TW, Macoska JA (1996) Distinct areas of allelic loss on chromosomal regions 10p and 10q in human prostate cancer. Cancer Res 56:2263-2267.
21. Visakorpi T, Kallioniemi AH, Syvanen AC, Hyytinen ER, Karhu R, Tammela T, Isola JJ, Kallioniemi OP (1995) Genetic changes in primary and recurrent prostate cancer by comparative genomic hybridization. Cancer Res 55:342-347.
22. Vocke C, Pozzatti RO, Bostwick DG, Florence CD, Jennings SB, Strup SE, Duray PH, Liotta LA, Emmert-Buck MR, Linehan WM (1996) Analysis of 99 microdissected prostate carcinomas reveals a high frequency of allelic loss on chromosome 8p12-21. Cancer Res 56:2411-2416.
23. Wolff DJ, Miller AP, Van Dyke DL, Schwarts S, Willard HF (1996) Molecular definition of breakpoints associated with human Xq isochromosomes: Implications for mechanisms of formation. Am J Hum Genet 58:154-160.
24. Wolman SR, Macoska JA, Micale MA, Sakr WA (1992) An approach to definition of genetic alterations in prostate cancer. Diag Mol Pathol 1:192-199.
25. Ye L, Nakura J, Mitsuda N, Fujioka Y, Kamino K, Ohta T, Jinno Y, Niikawa N, Miki T, Ogihiara T (1995) Genetic association between chromosome 8 microsatellite (MS8-134) and Wener syndrome (WRN): Chromosome microdissection and homozygosity mapping. Genomics 28:566-569.