Constitutive and interleukin-7- and interleukin-15-stimulated DNA binding of STAT and novel factors in cutaneous T cell lymphoma cells

Journal of Investigative Dermatology

Volumn 117, Issue 3, 2001, Pages 583-589

  Qin, J Z ^a   Kamarashev, J ^a   Zhang, C L ^a   Dummer, R ^a   Burg, G ^a   Dobbeling U ^a  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

Gene regulation; Oncogenes; Signal transduction; Transcription factors

Indexed keywords

INTERLEUKIN 15; INTERLEUKIN 7; STAT2 PROTEIN; STAT3 PROTEIN; STAT5 PROTEIN; STAT6 PROTEIN;

ARTICLE; BINDING AFFINITY; BINDING SITE; BLOOD; CELL NUCLEUS; CLINICAL ARTICLE; CONTROLLED STUDY; DNA BINDING; HUMAN; HUMAN CELL; HUMAN TISSUE; LEUKEMIA CELL LINE; LYMPHOMA CELL LINE; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; SEZARY SYNDROME; SKIN DEFECT; STIMULATION; T CELL LEUKEMIA; T LYMPHOCYTE;

EID: 0034792532     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.0022-202X.2001.01436.x     Document Type: Article

References (43)

1. IL-15 has stimulatory activity for the induction of B cell proliferation and differentiation
2. IL-15 and IL-16 overexpression in cutaneous T-cell lymphomas: Stage-dependent increase in mycosis fungoides progression
3. Mutually exclusive interaction of the CCAAT-binding factor and of a displacement protein with overlapping sequences of a histone gene promoter
4. Interleukin-15 mRNA is expressed by human keratinocytes, Langerhans cells, and blood derived dendritic cells and is downregulated by ultraviolet B radiation
5. STAT3-mediated constitutive expression of SOCS-3 in cutaneous T cell lymphoma
6. Cutaneous lymphomas
7. Interleukin-7 is a growth factor for Sézary lymphoma cells
8. IL-15 is an autocrine/paracrine viability factor for cutaneous T cell lymphoma cells
9. Sézary syndrome T-cell clones display T-helper 2 cytokines and express the accessory factor-1 (interferon-g receptor β-chain)
10. A new protein containing an SH2 domain that inhibits JAK kinases
11. Activation of STAT5 by interleukin 2 requires a carboxy-terminal region of the interleukin 2 receptor beta chain but is not essential for the proliferative signal transmission
12. In vitro transcription complementation assay with mini extracts of transiently transfected COS-1 cells
13. Utilization of the beta and gamma chains of the IL-2 receptor by the novel cytokine IL-15
14. Identification and cloning of a novel IL-15 binding protein that is structurally related to the alpha chain of the IL-2 receptor
15. STAT-related transcription factors are constitutively activated in peripheral blood cells from acute leukemia patients
16. Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptor
17. Receptor-associated constitutive protein tyrosine phosphatase activity controls the kinase function of JAK1
18. An interleukin-4-induced transcription factor
19. Tyrosine phosphorylation and activation of STAT5, STAT3, and Janus kinases by interleukins 2 and 15
20. A continuous T-cell line from a patient with Sézary syndrome
21. Jaks and STATs: Biological implications
22. Keratinocyte-derived IL-7 serves as a growth factor for dendritic epidermal T cells in mice
23. Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits
24. Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc, and lck cooperate in hemapoietic cell proliferation
25. Ultraviolet B radiation up-regulates the expression of IL-15 in human skin
26. Structure and function of a new STAT-induced STAT inhibitor
27. Interleukin-2 induces tyrosine phosphorylation and nuclear translocation of STAT3 in human T lymphocytes
28. Constitutive activation of a slowly migrating isoform of STAT3 in mycosis fungoides: Tyrpphostin AG490 inhibits STAT3 activation and growth of mycosis fungoides tumor cell lines
29. 'Bubble boy' paradox resolved
30. ErbB receptor induced activation of STAT transcription factors by Src tyrosine kinases
31. Constitutive and IL-7/IL-15 stimulated DNA-binding of Myc, Jun, and novel Myc-like proteins in cutaneous T cell lymphoma (CTCL) cells
32. IL-7 and IL-15 regulate the expression of the bcl-2 and c-myb genes in cutaneous T cell lymphoma (CTCL) cells
33. Interaction of IL-2R beta and gamma c chains with Jak1 and Jak3: Implications for XSCID XCID
34. The Bmx tyrosine kinase induces activation of the STAT signaling pathway, which is specifically inhibited by protein kinase Cdelta
35. Transcriptional responses to polypeptide ligands: The JAK-STAT pathway
36. Depressed IL-12 mediated signal transduction in T cells from patients with Sézary syndrome is associated with the absence of IL-12 receptor beta 2 mRNA and highly reduced levels of STAT4
37. A family of cytokine-inducible inhibitors of signalling
38. Proliferation of adult T cell leukemia/lymphoma cells is associated with the constitutive activation of JAK/STAT proteins
39. Interleukin 2 and erythropoietin activate STAT5/MGF via distinct pathways
40. Constitutive action of STAT proteins in primary lymphoid and myeloid leukemia cells and in Epstein-Barr virus (EBV) -related lymphoma cell lines
41. Kinase activation of the non-receptor tyrosine kinase Etk/Bmx alone is sufficient to transactivate STAT-mediated gene expression in salivary and lung epithelial cells
42. Enhanced DNA-binding activity of a Stat3-related protein in cells transformed by the Src oncoprotein
43. Activation of Jak/STAT proteins involved in signal transduction pathway mediated by receptor for interleukin 2 in malignant T lymphocytes derived from cutaneous anaplastic large T-cell lymphoma and Sézary syndrome