Expression profiles of COUP-TF, DAX-1, and SF-1 in the human adrenal gland and adrenocortical tumors: Possible implications in steroidogenesis

Molecular Genetics and Metabolism

Volumn 74, Issue 1-2, 2001, Pages 206-216

  Shibata, Hirotaka ^a   Ikeda, Yayoi ^b   Mukai, Tokuo ^c,d   Morohashi, Ken Ichirou ^c   Kurihara, Isao ^a   Ando, Takashi ^a   Suzuki, Toshihiko ^a   Kobayashi, Sakiko ^a   Murai, Masaru ^a   Saito, Ikuo ^a   Saruta, Takao ^a  

^a KEIO UNIVERSITY   (Japan)

^b UNIVERSITY OF TSUKUBA   (Japan)

^c NATIONAL INSTITUTE FOR BASIC BIOLOGY   (Japan)

^d KYUSHU UNIVERSITY   (Japan)

Author keywords

Adrenal tumor; COUP TF; Cushing syndrome; CYP17; DAX 1; Deoxycorticosterone producing adenomas; SF 1; Steroidogenesis

Indexed keywords

CHICKEN OVALBUMIN UPSTREAM PROMOTER TRANSCRIPTION FACTOR; CYTOCHROME P450; DEOXYCORTICOSTERONE; HORMONE RECEPTOR; HYDROCORTISONE; STEROID 17ALPHA MONOOXYGENASE; STEROIDOGENIC FACTOR 1;

ADRENAL CORTEX TUMOR; ADRENAL GLAND; ADRENAL SCINTISCANNING; ANGIOGRAPHY; ARTICLE; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; CUSHING SYNDROME; ENZYME ACTIVITY; GENE; GENETIC TRANSCRIPTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; STEROIDOGENESIS;

GALLUS GALLUS;

EID: 0034788474     PISSN: 10967192     EISSN: None     Source Type: Journal    
DOI: 10.1006/mgme.2001.3231     Document Type: Article

References (52)

1. Aldosterone synthase cytochrome P-450 expressed in the adrenals of patients with primary aldosteronism
2. Expression of cytochrome P-450 mRNAs in steroidogenesis of adrenocortical adenomas from patients with primary aldosteronism
3. Significance of steroidogenic enzymes in the pathogenesis of adrenal tumour
4. Adrenal tumor producing 11-deoxycorticosterone, 18-hydroxy-11-deoxycorticosterone and aldosterone
5. Ad4BP regulating steroidogenic P-450 gene is a member of steroid hormone receptor superfamily
6. Steroidogenic factor 1 is the essential transcript of the mouse Ftz-F1 gene
7. Ad4BP/SF-1, a transcription factor essential for the transcription of steroidogenic cytochrome P450 genes and for the establishment of the reproductive function
8. Steroidogenic factor 1: A key determinant of endocrine development and function
9. Regulation of the apolipoprotein AI gene by ARP-1, a novel member of the steroid receptor superfamily
10. Transcriptional activation by the orphan nuclear receptor ARP-1
11. Chick ovalbumin upstream promoter-transcription factors (COUP-TFs): Coming of age
12. COUP transcription factor is a member of the steroid receptor superfamily
13. Mutually exclusive interactions of two nuclear orphan receptors determine activity of a cyclic adenosine 3′,5′-monophosphate-responsive sequence in the bovine CYP17 gene
14. Biochemical and functional analysis of nuclear receptors as targets in cAMP-dependent control of bovine CYP17
15. Mutations in the DAX-1 gene give rise to both X-linked adrenal hypoplasia congenita and hypogonadotropic hypogonadism
16. An unusual member of the nuclear hormone receptor superfamily responsible for X-linked adrenal hypoplasia congenita
17. Gene silencing by chicken ovalbumin upstream promoter-transcription factor I (COUP-TFI) is mediated by transcriptional corepressors, nuclear receptor-corepressor (N-CoR) and silencing mediator for retinoic acid receptor and thyroid hormone receptor (SMRT)
18. Role of co-activators and co-repressors in the mechanism of steroid/thyroid receptor action
19. Steroidogenic factor-1: Its role in endocrine organ development and differentiation
20. Phosphorylation of the nuclear receptor SF-1 modulates cofactor recruitment: Integration of hormone signaling in reproduction and stress
21. Nuclear receptor DAX-1 recruits nuclear receptor corepressor N-CoR to steroidogenic factor 1
22. Functional role of COUP-TFI, SF-1, and nuclear receptor coregulators in the steroidogenesis of adrenocortical adenomas
23. Chicken ovalbumin upstream promoter transcription factor II in the human adrenal cortex and its disorders
24. Benign desoxycorticosterone-producing adrenal tumor
25. Mass spectrometry in the diagnosis of steroid-related disorders and in hypertension resesarch
26. Steroidogenesis in liposomal system containing adrenal microsomal cytochrome P-450 electron transfer components
27. Steroid contents and cortical steroidogenic enzymes in non-hyperfunctioning adrenal adenoma
28. Dax-1 as one of the target genes of Ad4BP/SF-1
29. Activation of CYP11A and CYP11B gene promoters by the steroidogenic cell-specific transcription factor, Ad4BP
30. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
31. Quantitative electrophoretic transfer of polypeptides from SDS polyacrylamide gels to nitrocellulose sheets: A method for their re-use in immunoautoradiographic detection of antigens
32. Steroidogenic factor 1 and Dax-1 colocalize in multiple cell lineages: Potential links in endocrine development
33. Differential expression of an orphan receptor COUP-TFI and corepressors in adrenal tumors
34. COUP-TFI expression in human adrenocortical adenomas: Possible role in steroidogenesis
35. DAX-1 expression in human adrenocortical neoplasms: Implications for steroidogenesis
36. Ad4BP in the human adrenal cortex and its disorders
37. Transcriptional regulation of the bovine CYP17 gene by cAMP
38. Multiple orphan nuclear receptors converge to regulate rat P450c17 gene transcription: Novel mechanisms for orphan nuclear receptor action
39. Expression profiles of SF-1, DAX1, and CYP17 in the human fetal adrenal gland: Potential interactions in gene regulation
40. Novel role for the nuclear phosphoprotein SET in transcriptional activation of P450c17 and initiation of neurosteroidogenesis
41. The murine Dax-1 promoter is stimulated by SF-1 (steroidogenic factor- 1) and inhibited by COUP-TF (chicken ovalbumin upstream promoter-transcription factor) via a composite nuclear receptor-regulatory element
42. Aromatase as a therapeutic target in endometriosis
43. Stimulation of aromatase P450 promoter (II) activity in endometriosis and its inhibition in endometrium are regulated by competitive binding of steroidogenic factor-1 and chicken ovalbumin upstream promoter transcription factor to the same cis-acting element
44. Aromatase: A key molecule in the pathophysiology of endometriosis and a therapeutic target
45. Angiotensin II and potassium regulate human CYP11B2 transcription through common cis-elements
46. Two orphan receptors binding to a common site are involved in the regulation of the oxytocin gene in the bovine ovary
47. Chicken ovalbumin upstream promoter transcription factor (COUP-TF): Expression during mouse embryogenesis
48. The orphan nuclear receptor COUP-TFII is required for angiogenesis and heart development
49. Cytochrome b5 augments the 17,20-lyase activity of human P450c17 without direct electron transfer
50. Molecular biology of steroid hormone synthesis
51. High expression of cytochrome b5 in adrenocortical adenomas from patients with Cushing's syndrome associated with high secretion of adrenal androgens
52. In-vitro evidence for the regulation of 17,20-lyase activity by cytochrome b5 in adrenocortical adenomas from patients with Cushing's syndrome