Heat shock protein-based therapeutic strategies against human immunodeficiency virus type I infection

Infectious Diseases in Obstetrics and Gynecology

Volumn 7, Issue 1-2, 1999, Pages 80-90

  Brenner, B G ^a   Wainberg, M A ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

AIDS; Cyclophilin A; Cytotoxic T lymphocyte; NK immunity; Viral host interactions

Indexed keywords

BCG VACCINE; CAPSID PROTEIN; CHAPERONE; CYCLOPHILIN A; GAG PROTEIN; HEAT SHOCK PROTEIN; HEAT SHOCK PROTEIN 27; HEAT SHOCK PROTEIN 70; HUMAN IMMUNODEFICIENCY VIRUS VACCINE; VIRUS PROTEIN;

ANIMAL EXPERIMENT; ANTIBODY DEPENDENT CELLULAR CYTOTOXICITY; CONFERENCE PAPER; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; HEAT STRESS; HELPER CELL; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MOUSE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN FOLDING; VIRION; VIRUS CELL INTERACTION;

EID: 0032928522     PISSN: 10647449     EISSN: None     Source Type: Journal    
DOI: 10.1002/(sici)1098-0997(1999)7:1/2<80::aid-idog15>3.0.co;2-m     Document Type: Conference Paper

References (82)

1. Letvin NL. Progress in the development of an HIV-1 vaccine. Science 1998;280:1875-1880.
2. Steinman RM, Germain RN. Antigen presentation and related immunological aspects of HIV-1 vaccines. AIDS 1998;12:S97-S112.
3. Gething MJ, Sambrook J. Protein folding in the cell. Nature 1992;355:33-45.
4. Craig EA, Weissmann JA, Horwich AL. Heat shock proteins and molecular chaperones: Mediators of protein conformation and turnover in the cell. Cell 1994;78:365-372.
5. Morimoto RI, Tissières A, Georgopoulos C. Progress and perspectives on the biology of heat shock proteins and molecular chaperones. In Morimoto RI, Tissières A, Georgopoulos C (eds): The Biology of Heat Shock Proteins and Molecular Chaperones. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press, 1994, pp 1-30.
6. Morimoto RI. Cells in stress: transcriptional activation of heat shock genes. Science 1993;259:1409-1410.
7. Craig EA, Gambill BD, Nelson RJ. Heat shock proteins: Molecular chaperones of protein biogenesis. Microbiol Rev 1993;57:402-414.
8. James P, Pfund C, Craig EA. Functional specificity among hsp70 molecular chaperones. Science 1997;275: 387-391.
9. Rutherford SL, Zuker CS. Protein folding and the regulation of signalling pathways. Cell 1994;79:1129-1132.
10. Arrigo AP, Landry J. Expression and function of low molecular weight heat shock proteins. In Morimoto RI, Tissières A, Georgopoulos C (eds): The Biology of Heat Shock Proteins and Molecular Chaperones. Cold Spring Harbor: Cold Spring Harbor Laboratory Press, 1994, pp 335-373.
11. Mehlen P, Preville X, Charyron P, Briolay J, Klemenz R, Arrigo AP. Constitutive expression of human hsp27, Drosophila hsp27, or human alpha B-crystallin confers resistance to TNF- and oxidative stress-induced cytotoxicity in stable transfected murine L929 fibroblasts. J Immunol 1995;154:363-374.
12. Rouse J, Cohen P, Trigon S, et al. A novel kinase cascade triggered by chemical stress and heat shock which stimulates MAP kinase-activated protein kinase-2 and phosphorylation of the small heat shock proteins. Cell 1994;78:1027-1037.
13. Freshney NW, Rawlinson L, Guesden F, et al. Interleukin-1 activates a novel protein cascade which results in phosphorylation of hsp27. Cell 1994;78:1039-1049.
14. Dubois P. Heat shock proteins and immunity. Res Immunol 1989;140:653-659.
15. DeNagel DC, Pierce SR. Heat shock proteins in immune response. Crit Rev Immunol 1993;13:71-81.
16. Mizzen L. Immune responses to stress proteins: Applications to infectious disease and cancer. Biotechnology 1998;10:173-189.
17. Newport GR. Heat shock proteins as vaccine candidates. Semin Immunol 1991;3:17-24.
18. Boltzer C, Li G, Issels RD, Multhoff G. Definition of extracellular localized epitopes of hsp70 involved in an NK immune response. Cell Stress Chaperones 1998;3: 6-11.
19. Srivastava PK. Heat shock proteins in immune response to cancer: The fourth paradigm. Experientia 1994;50: 1054-1060.
20. Santoro MG. Heat shock proteins and virus replication: hsp70s as mediators of antiviral effects of prostaglandins. Experientia 1994;50:1039-1047.
21. Born W, Happ M, Dallas A, et al. Recognition of heat shock proteins and cell function. Immunol Today 1990; 11:40-43.
22. Multhoff G, Boltzer C, Wiesnet M, et al. A stress-inducible 72kda heat-shock protein (HSP72) is expressed on the surface of human tumor cells, but not on normal cells. Int J Cancer 1995;61:272-275.
23. DiCesare S, Poccia F, Mastino A, Colizzi V. Surface expressed heat-shock proteins by stressed or human immunodeficiency virus (HIV)-infected lymphoid cells represent the target for antibody-dependent cellular cytotoxicity. Immunology 1992;76:341-343.
24. Poccia F, Placido R, Mancino G, et al. Expression of heat-shock proteins in HIV-1 infection. In Montagnier L, Gougeon ML (eds): New Concepts in AIDS pathogenesis. New York: Marcel Dekker Inc, 1993, pp 195-218.
25. Multhoff G, Botzler C, Jennen L, Schmidt J, Ellwart J, Issels R. Heat shock protein on tumor cells: A recognition structure for natural killer cells. J Immunol 1997; 158:4341-4350.
26. Multhoff G, Boltzer C, Wiesnet M, Eissner G, Issels R. CD3- large granular lymphocytes recognize a heat-inducible immunogenic determinant associated with the 72-kD heat shock protein on human sarcoma cells. Blood 1995;86:1374-1382.
27. Fujeida S, Noda I, Saito H, Hoshino T, Yagita M. Heat shock enhances the susceptibility of tumor cells to lysis by lymphokine activated killer cells. Arch Otolaryngol Head Neck Surg 1995;121:1009-1014.
28. van Eden W, van der Zee R, Paul AGA, et al. Do heat shock proteins control the balance of T cell regulation in inflammatory diseases. Immunol Today 1998;19:303-307.
29. Ikonomidis G, Paterson Y, Kos FJ, Portnoy DA. Delivery of a viral antigen to class 1 processing and presentation pathways by Listeria monocytogenes. J Exp Med 1994;180:2209-2218.
30. Aldovini A, Young RA. Humoral and cell-mediated immune responses to live recombinant BCG-HIV vaccines. Nature 1991;351:479-482.
31. Suzue K, Young RA. Adjuvant-free hsp70 fusion protein system elicits humoral and cellular immune responses to HIV-1 p24. J Immunol 1996;156:873-879.
32. Young RA, Suzue K. Heat shock proteins as immunological carriers and vaccines. EXS 1996;77:451-465.
33. Li Z, Srivastava KI. A critical contemplation of the role of heat shock proteins in transfer of antigenic peptides during antigen presentation. Behring Inst Mitt 1994;94: 37-47.
34. Pierce SK. Molecular chaperones in the processing and presentation of antigen to helper cells. Experientia 1994;50:1026-1030.
35. Suto R, Srivastava PK. A mechanism for the specific immunogenicity of heat shock protein-chaperoned peptides. Science 1995;269:1585-1588.
36. Suzue K, Zhou X, Eisen HN, Young RA. Heat shock proteins as vehicles for antigen delivery into the major histocompatibility complex class 1 presentation pathway. Proc Natl Acad Sci USA 1997;94;13146-13151.
37. Srivastava PK. Peptide-binding heat shock proteins in the endoplasmic reticulum: role in immune response to cancer and antigen presentation. Adv Cancer Res 1993; 62:153-177.
38. Sargent CA, Dunham I, Trowsdale J, Campbell RD. Human major histocompatibility complex contains genes for the major heat shock protein HSP70. Proc Natl Acad Sci USA 1989;86:1968-1972.
39. Srivastava PK. Purification of heat shock protein-peptide complexes for use in vaccination against cancers and intracellular pathogens. Methods 1997;12:165-171.
40. Tamara Y, Peng P, Liu K, Daou M, Srivastava PK. Immunotherapy of tumors with autologous tumor-derived heat shock protein preparations. Science 1997;278:117-120.
41. Ciupitu AM, Petersson M, O'Donnell CL, Williams K, Jindal S, Kiessling R, Welsh RM. Immunization with a lymphocytic choriomeningitis virus peptide mixed with heat shock protein 70 results in protective antiviral immunity and specific cytotoxic T lymphocytes. J Exp Med 1998;187:685-691.
42. Li Z. Priming of T cells by heat shock protein-peptide complexes as the basis of tumor vaccines. Semin Immunol 1997;9:315-322.
43. Blachere NE, Li Z, Chandawarkar RY, et al. Heat shock protein-peptide complexes, reconstituted in vivo, elicit ptide-specific cytotoxic T lymphocyte response and tumor immunity. J Exp Med 1997;186:1315-1322.
44. Heikema A, Agsteribbe E, Wilschut J, Huckriede A. Generation of heat shock protein-based vaccines by intracellular loading of gp96 with antigenic peptides. Immunol Lett 1997;57:69-74.
45. Srivastava PK, DeLeo AB, Old LJ. Tumour rejection antigens of chemically induced tumours of inbred mice. Proc Natl Acad Sci USA 1986;83:3407-3411.
46. Maxwell CA, Durrant LG, Scholefield JH. Colorectal cancer vaccines. Brit J Surg 1998;85:149-154.
47. Featherstone C. Chaperoning tumour antigens into the immune system. Lancet 1996;348:1438.
48. Santoro MG. Viral infection. EXS 1996;77:337-357.
49. Luban J. Absconding with the chaperone: essential cyclophilin-Gag interaction in HIV-1 chaperones. Cell 1996;87:1157-1159.
50. Phillips B, Abravya K, Morimoto RI. Analysis of the specificity and mechanism of transcriptional activation of the human hsp70 gene during infection by DNA viruses. J Virol 1991;65:5680-5692.
51. Wainberg Z, Oliveira M, Lerner S, Tao Y, Brenner BG. Modulation of stress protein (hsp27 and hsp70) expression in CD4+ lymphocytic cells following acute infection with human immunodeficiency virus type 1. Virology 1997;233:364-373.
52. Furlini G, Vignoli M, Le MC, et al. Human immunodeficiency virus type 1 interaction with the membrane of CD4+ cells induces the synthesis and nuclear translocation of 70K heat shock protein. J Gen Virol 1994;75: 193-199.
53. Geelen JL, Minnaar RP, Boom R, van der Noordaa J, Goudsmit J. Heat-shock induction of the human immunodeficiency virus long terminal repeat. J Gen Virol 1988;69:2913-2917.
54. Kretz-Remy C, Arrigo AP. The kinetics of HIV-1 long terminal repeat transcriptional activation resemble those of the hsp70 promoter in heat-shock treated Hela cells. FEBS Lett 1994;353:339-343.
55. Stanley SK, Bressler PB, Poli G and Fauci AS. Heat shock induction of HIV production from chronically infected promonocytic and T cell lines. J Immunol 1990; 145:1120-1126.
56. Brenner BG, Tao Y, Pearson E, Remer I, Wainberg MA. Altered constitutive and stress-regulated heat shock protein 27 expression in HIV type 1-infected cell lines. AIDS Res Hum Retroviruses 1995;11:713-717.
57. 1 on herpes simplex virus and immunodeficiency virus replication. Antimicrob Agents Chemother 1992;36:2253-2258.
58. D'Onofrio C, Alvino E, Garaci E, Bonmassar E, Santoro MG. Selection of HTLV-1 positive clones is prevented by prostaglandin A in infected cord blood cultures. Brit J Cancer 1990;61:207-214.
59. Ankel H, Turriziani O, Antonelli G. Prostaglandin A inhibits replication of human immunodeficiency virus during acute infection. J Gen Virol 1991;72:2797-2800.
60. Rozera C, Carattoli A, De Marco A, Amici C, Giorgi C, Santoro MG. Inhibition of HIV-1 replication by cyclopentenone prostaglandins in acutely infected human cells. J Clin Invest 1996;97:1795-1803.
61. Rossi A, Elia G, Santoro MG. 2-Cyclopentenone, a new inducer of HSP70 with antiviral activity. J Biol Chem 1996;271:32192-32196.
62. Pennypacker C, Perelson AS, Nys N, Nelson G, Sessler DI. Localized or systemic in vivo heat inactivation of HIV: a mathematical analysis. J Acquir Immun Defic Syndr Hum Retrovirol 1995;8:321-329.
63. Brenner BG, Gryllis C, Wainberg MA. Role of antibody-dependent cellular cytotoxicity and lymphokine-activated killer cells in AIDS and related diseases. J Leukoc Biol 1991;50:628-640.
64. Gryllis C, Wainberg MA, Bentwich Z, Gornitsky M, Brenner BG. Increased LAK activity against HIV-infected cell lines in HIV-1+ individuals. Clin Exp Immunol 1992;89:356-361.
65. Brenner BG, Gryllis C, Gornitsky M, Wainberg MA. Changes in natural immunity during the course of HIV-1 infection. Clin Exp Immunol 1993;93:142-148.
66. Gryllis C, Wainberg MA, Gornitsky M, Brenner B. Diminution of inducible lymphokine-activated killer cell activity in individuals with AIDS-related disorders. AIDS 1990;4:1205-1212.
67. Brenner BG, Dascal A, Margolese RG, Wainberg MA. Natural killer cell function in patients with acquired immunodeficiency syndrome (AIDS) and HIV-1-associated disorders. J Leukoc Biol 1989;46:75-83.
68. Brenner BG, Gornitsky M, Wainberg MA. IL-2 inducible natural immune (LAK) responses as a functional correlate of progression to AIDS. Clin Diag Lab Immunol 1994;1:538-544.
69. Earl PL, Moss B, Doms RW. Folding and interaction with GRP78-BiP, assembly, transport, of the HIV-1 envelope protein. J Virol 1991;65:2047-2055.
70. Otteken A, Moss B. Calreticulin interacts with newly synthesized human immunodeficiency virus type 1 envelope glycoprotein suggesting a chaperone function similar to that of calnexin. J Biol Chem 1996;271:97-103.
71. Cullen BR, Heitman J. Chaperoning a pathogen. Nature 1994;372:359-360.
72. Thali M, Bukovsky A, Kondo E, et al. Functional association of cyclophilin A with HIV-1 virions. Nature 1994;372:363-365.
73. Franke EK, Yuan HEH, Luban J. Specific incorporation of cyclophilin into HIV-1 virions. Nature 1994;372:359-362.
74. Braaten D, Franke EK, Luban J. Cyclophilin A is required for an early step in the life cycle of human immunodeficiency virus type 1 before the initiation of reverse transcription. J Virol 1996;70:3551-3560.
75. Billich A, Hammerschmid F, Peichl P, et al. Mode of action of SDZ NIM 811, a non immunosuppressive cyclosporin A analog with activity against HIV type 1: interference with HIV protein-cyclophilin A interactions. J Virol 1995;69:2451-2461.
76. CPZGAB but not the group O HIV-1 or other primate immunodeficiency viruses. J Virol 1996;70: 4220-4227.
77. Yin L, Braaten D, Luban J. Human immunodeficiency virus type 1 replication is modulated by host cyclophilin A expression levels. J Virol 1998;72:6430-6436.
78. Aiken C. Mechanistic independence of Nef and cyclophilin A enhancement of human immunodeficiency virus type 1 infectivity. Virology 1998;24:139-147.
79. Endrich MM, Gehring H. The V3 loop of human immunodeficiency virus type-1 envelope protein is a high-finity ligand for immunophilins present in blood. Eur J Biochem 1998;252:441-446.
80. Sherry B, Zybarth G, Alfano M, et al. The role of cyclophilin A in the uptake of HIV-1 by macrophages. Proc Natl Acad Sci USA 1998;95:1758-1763.
81. Bartz SR, Pauza CD, Ivanyi J, Jindal S, Welch WJ, Malkovsky M. An hsp60 related protein is associated with purified HIV and SIV. J Med Primatol 1994;23: 151-154.
82. Nieland TJF, Tan MCAA, Monnee-van Muijen M, Koning F, Kruisbeek M, van Bleek GM. Isolation of an immunodominant peptide that is endogenously bound to stress protein GP96/GRP94. Proc Natl Acad Sci USA 1996;93:6135-6139.