Dissociation of the motor effects of (+)-pentazocine from binding to σ1 sites

European Journal of Pharmacology

Volumn 301, Issue 1-3, 1996, Pages 31-40

  Matsumoto, Rae R ^a,b   Bowen, Wayne D ^c,d   Walker, J Michael ^b   Patrick, Saundra L ^b   Zambon, Alexander C ^a   Vo, Van Nhi ^a   Truong, Daniel D ^a   De Costa, Brian R ^d   Rice, Kenner C ^d  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b BROWN UNIVERSITY   (United States)

^c BROWN UNIVERSITY   (United States)

^d NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

(+) Pentazocine; Opiate; Red nucleus; Substantia nigra; Site

Indexed keywords

HALOPERIDOL; N [2 (2,3 DICHLOROPHENYL)ETHYL] 2 DIMETHYLAMINO N METHYLETHYLAMINE; NALOXONE; NORHYDROCODONE; OPIATE AGONIST; OPIATE ANTAGONIST; OPIATE RECEPTOR; PENTAZOCINE; RADIOLIGAND; SIGMA 1 OPIATE RECEPTOR; SIGMA 2 OPIATE RECEPTOR; SIGMA OPIATE RECEPTOR; SIGMA OPIATE RECEPTOR ANTAGONIST; UNCLASSIFIED DRUG;

AGE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BEHAVIOR; BODY POSTURE; CIRCLING BEHAVIOR; CONTROLLED STUDY; DRUG ANTAGONISM; DYSTONIA; INTRACEREBRAL DRUG ADMINISTRATION; MALE; MOTOR ACTIVITY; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR AFFINITY; RECEPTOR BINDING; RED NUCLEUS; SCATCHARD PLOT; SUBCUTANEOUS DRUG ADMINISTRATION; SUBSTANTIA NIGRA;

EID: 0029940379     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-2999(96)00008-8     Document Type: Article

References (37)

1. Booth, R.G., S.D. Wyrick, R.J. Baldessarini, N.S. Kula, A.M. Myers and R.B. Mailman, 1993, New σ-like receptor recognized by novel phenylaminotetralins: ligand binding and functional studies, Mol. Pharmacol. 44, 1232.
2. Bowen, W.D., S.B. Hellewell and K.A. McGarry, 1989, Evidence for a multi-site model of the rat brain σ receptor, Eur. J. Pharmacol. 163, 309.
3. 3H]-(+)-Pentazocine: a potent and highly selective benzomorphan-based probe for sigma-1 receptors, Mol. Neuropharmacol. 3, 117.
4. Bowen, W.D., B.J. Vilner, K.S. Lee, X.-S. He, B.R. De Costa and D.R. Weinberger, 1995, A haloperidol-insensitive binding site for sigma-active aryl ethylene diamine-related compounds: a novel sigma receptor subtype?, Soc. Neurosci. Abstr. 21, 526.
5. Boyson, S.J., P. McGonigle and P.B. Molinoff, 1986 Quantitative autoradiographic localization of the D1 and D2 subtypes of dopamine receptors in brain, J. Neurosci. 6, 3177.
6. 3H]tolyl)guanidine labels more than one site in rat forebrain. Eur. J. Pharmacol. 217, 149.
7. 3H]-(+)-pentazocine, a highly potent and selective radioligand for sigma receptors, FEBS Lett. 251, 53.
8. De Costa, B.R., L. Radesca, L. DiPaolo and W.D. Bowen, 1992, Synthesis, characterization, and biological evaluation of a novel class of N-(arylethyl)-N-alkyl-2-(1-pyrrolidinyl)ethylamines: structural requirements and binding affinity at the sigma receptor, J. Med. Chem. 35, 38.
9. 3H]1,3-dio-tolylguanidine binding sites with low affinity for haloperidol in rat brain, Biol. Pharm. Bull. 16, 989.
10. Goldstein, S.R., R.R. Matsumoto, T.L. Thompson, R.L. Patrick, W.D. Bowen and J.M. Walker, 1989, Motor effects of two sigma ligands mediated by nigrostriatal dopamine neurons. Synapse 4, 254.
11. 3H-3-(3-hydroxyphenyl)-N-(1-propyl)piperidine, J. Neurosci. 6, 1757.
12. Hellewell, S.B. and W.D. Bowen, 1990, A sigma-like binding site in rat pheochromocytoma (PC12) cells: decreased affinity for (+)-benzomorphans and lower molecular weight suggest a different sigma receptor form from that in guinea pig brain, Brain Res. 527, 244.
13. Hellewell, S.B., A. Bruce, G. Feinstein, J. Orringer, W. Williams and W.D. Bowen, 1994, Rat liver and kidney contain high densities of sigma-1 and sigma-2 receptors: Characterization by ligand binding and photoaffinity labelling, Eur. J. Pharmacol. Mol. Pharmacol. Sect. 268, 9.
14. Hemstreet, M.K., R.R. Matsumoto, W.D. Bowen and J.M. Walker, 1993, σ Binding parameters in developing rats predict behavioral efficacy of a σ ligand, Brain Res. 627, 291.
15. Jones, C.R. and J.M. Palacios, 1991, Autoradiography of adrenoceptors in rat and human brain: α-adrenoceptor and idazoxan binding sites, Prog. Brain Res. 88, 271.
16. Lowry, O.H., N.J. Rosebrough, A.L. Farr and R.J. Randall, 1951, Protein measurement with the Folin phenol reagent, J. Biol. Chem. 193, 265.
17. Mansour, A., H. Khachaturian, M.E. Lewis, H. Akil and S. Watson, 1987. Autoradiographic differentiation of mu, delta, and kappa opioid receptors in the rat forebrain and midbrain, J. Neurosci. 7, 2445.
18. Matsumoto, R.R., W.D. Bowen and J.M. Walker, 1989a, Age-related differences in the sensitivity of rats to a selective sigma ligand, Brain Res. 504, 145.
19. Matsumoto, R.R., W.D. Bowen and J.M. Walker, 1989b, Chronic haloperidol treatment differentially regulates dopamine and sigma receptors, Soc. Neurosci. Abstr. 15, 221.16.
20. Matsumoto, R.R., M.K. Hemstreet, N.L. Lai, A. Thurkauf, B.R. De Costa, K.C. Rice, S.B. Hellewell, W.D. Bowen and J.M. Walker, 1990, Drug specificity of pharmacological dystonia, Pharmacol. Biochem. Behav. 36, 151.
21. Matsumoto, R.R., W.D. Bowen, B.R. De Costa and J.C. Houk, 1992, A novel sigma binding site that may negatively modulate excitatory amino acid neurotransmission, Soc. Neurosci. Abstr. 18, 16.7.
22. Matsumoto, R.R., W.D. Bowen, M.A. Tom, V.N. Vo, D.D. Truong and B.R. De Costa, 1995, Characterization of two novel sigma ligands: antidystonic effects in rats suggest sigma receptor antagonism, Eur. J. Pharmacol. 280, 301.
23. Paxinos, G. and C. Watson, 1986, The Rat Brain in Stereotaxic Coordinates, 2nd edn. (Academic Press, New York).
24. Pazos, A. and J.M. Palacios, 1985, Quantitative autoradiographic mapping of serotonin receptors in the rat brain. I. Serotonin-1 receptors, Brain Res. 346, 205.
25. Quirion, R., R.P. Hammer, Jr., M. Herkenham and C.B. Pert, 1981, Phencyclidine (angel dust)/sigma "opiate" receptor: visualization by tritium-sensitive film, Proc. Natl. Acad. Sci. 78, 5881.
26. Quirion, R., W.D. Bowen, Y. Itzhak, J.L. Junien, J.M. Musacchio, R.B. Rothman, T.-P. Su, S.W. Tam and D.P. Taylor, 1992, A proposal for the classification of sigma binding sites, Trends Pharmacol. Sci. 13, 85.
27. Rice, K.C., 1985, The development of a practical total synthesis of natural and unnatural codeine, morphine, and thebaine, in: The Chemistry and Biology of Isoquinoline Alkaloids, eds. J.D. Phillipson, M.F. Roberts, M.H. Zenk (Springer-Verlag, New York) p. 191.
28. 3H]haloperidol binding in guinea pig brain membranes, Proc. Natl. Acad. Sci. USA 81, 5618.
29. 3H](+)-pentazocine in clonal cell lines, Soc. Neurosci. Abstr. 18, 22.
30. 3H](+)-pentazocine, in: Problems of Drug Dependence, 1992: Proceedings of the 54th Annual Scientific Meeting, National Institute on Drug Abuse Research Monograph 132, eds. L.S. Harris (U.S. Government Printing Office, Washington DC) p. 407.
31. Vilner, B.J., B.R. De Costa and W.D. Bowen, 1995a, Cytotoxic effects of sigma ligands: sigma receptor-mediated alterations in cellular morphology and viability, J. Neurosci. 15, 117.
32. Vilner, B.J., C.S. John and W.D. Bowen, 1995b, Sigma-1 and sigma-2 receptors are expressed in a wide variety of human and rodent tumor cell lines. Cancer Res. 55, 408.
33. Walker, J.M., W.D. Bowen, F.O. Walker, R.R. Matsumoto, B.R. De Costa and K.C. Rice, 1990a, Sigma receptors: biology and function, Pharmacol. Rev. 42, 355.
34. Walker, J.M., S.L. Patrick, A. Thurkauf, K.C. Rice and W.D. Bowen, 1990b, Inhibition of cholinergic analgesia by (+)-opiates, Prog. Clin. Biol. Res. 328, 81.
35. 2 receptors in motor function, Eur. J. Pharmacol. 231, 61.
36. Walker, J.M., W.J. Martin, A.G. Hohmann, M.K. Hemstreet, J.S. Roth, M.L. Leitner, S.D. Weiser, S.L. Patrick, R.L. Patrick and R.R. Matsumoto, 1994, Role of sigma receptors in brain mechanisms of movement, in: Sigma Receptors, ed. Y. Itzhak (Academic Press, San Diego) p. 205.
37. Wu, X.-Z., J.A. Bell, C.E. Spivak, E.D. London and T.-P. Su, 1991, Electrophysiological and binding studies on intact NCB-20 cells suggest presence of low affinity sigma receptor, J. Pharmacol. Exp. Ther. 257, 351.