Induction of apoptosis in AK-5 tumor cells by a serum factor from tumor rejecting animals: Cytochrome c release independent of Bcl-2 and caspases

Cell Death and Differentiation

Volumn 8, Issue 10, 2001, Pages 1038-1046

  Anjum, R ^a   Joshi, P ^a   Khar, A ^a  

^a CENTRE FOR CELLULAR AND MOLECULAR BIOLOGY   (India)

Author keywords

Apoptosis; Cytochrome c; Mitochondria; Tumor regression

Indexed keywords

BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; CASPASE; CYCLOSPORIN A; CYTOCHROME C; DNA FRAGMENT; PROTEIN BCL 2;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CANCER IMMUNOTHERAPY; CELL KILLING; CONTROLLED STUDY; CYTOSOL; HISTIOCYTOMA; HOST; IMMUNOCOMPETENT CELL; IMMUNOREGULATION; MEMBRANE POTENTIAL; MITOCHONDRION; MOLECULAR BIOLOGY; NONHUMAN; PRIORITY JOURNAL; RAT; SERUM FACTOR; TUMOR CELL; TUMOR REJECTION;

ANIMALS; APOPTOSIS; BIOLOGICAL FACTORS; BIOLOGICAL TRANSPORT; CASPASES; CYCLOSPORINE; CYTOCHROME C GROUP; HISTIOCYTOMA, BENIGN FIBROUS; INTRACELLULAR MEMBRANES; MEMBRANE POTENTIALS; MITOCHONDRIA; NEOPLASM TRANSPLANTATION; PERMEABILITY; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; SKIN NEOPLASMS; TRANSFECTION; TUMOR CELLS, CULTURED;

ANIMALIA;

EID: 0034772406     PISSN: 13509047     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cdd.4400915     Document Type: Article

References (43)

1. Apoptosis in the pathogenesis and treatment of disease
2. Caspases: Killer proteases
3. Suicidal tendencies: Apoptotic cell death by caspase family proteinases
4. Caspases: Intracellular signalling by proteolysis
5. Mitochondria as the central control point of apoptosis
6. Mitochondrial control of apoptosis
7. Mitochondrial cytochrome C release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization
8. Bcl-2 prolongs cell survival after Bax-induced release of cytochrome C
9. Cell-free apoptosis in Xenopus egg extracts: Inhibition by Bcl-2 and requirement for an organelle fraction enriched in mitochondria
10. Induction of apoptotic program in cell-free extracts: Requirement for dATP and cytochrome C
11. Prevention of apoptosis by Bcl-2: Release of cytochrome C from mitochondria blocked
12. The release of cytochrome C from mitochondria: A primary site for Bcl-2 regulation of apoptosis
13. Bcl-2 inhibits the mitochondrial release of an apoptogenic protease
14. Cytochrome C and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
15. Inhibition of Bax channel-forming activity by Bcl-2
16. Bcl-2 family proteins regulate the release of apoptogenic cytochrome C by the mitochondrial channel VDAC
17. The mitochondrial permeability transition
18. Development and characterization of a rat histiocyte-macrophage tumor line
19. Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: Inhibition by overexpression of Bcl-2 and Abl
20. Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE
21. Commitment to apoptosis is associated with changes in mitochondrial biogenesis and activity in cell lines conditionally immortalized with simian virus 40
22. Inhibitors of permeability transition interfere with the disruption of mitochondrial membrane potential during apoptosis
23. Apoptosis induced by anticancer drugs
24. Fas ligand-induced apoptosis as a mechanism of immune privilege
25. Mechanism of antibody dependent natural killer cell-mediated AK-5 tumor cell death
26. Natural killer cell as the effector which mediates in vivo apoptosis in AK-5 tumor cells
27. Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation
28. Regulation of phosphatidylserine exposure and phagocytosis of apoptotic T lymphocytes
29. Apoptosis in the absence of cytochrome C accumulation in the cytosol
30. Cytochrome C dependent and independent induction of apoptosis in multiple myeloma cells
31. L regulates the membrane potential and volume homeostasis of mitochondria
32. Bax directly induces release of cytochrome C from isolated mitochondria
33. The release of cytochrome C from mitochondria during apoptosis of NGF-deprived sympathetic neurons is a reversible event
34. Apoptosis-associated derangement of mitochondrial function in cells lacking mitochondrial DNA
35. The mitochondrial permeability transition pore and its role in cell death
36. The mitochondrion in cell death control: Certainties and incognita
37. Cell cycle control, DNA repair and initiation of carcinogenesis
38. Adaptation of rat histiocytoma cells AK-5, to growth in culture. In vitro
39. A novel assay for apoptosis flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled annexin V
40. Suppression of apoptosis by nitric oxide via inhibition of interleukin-1beta-converting enzyme (ICE)-like and cysteine protease protein (CPP)-32-like proteases
41. Fluorometric and colorimetric detection of caspase activity associated with apoptosis
42. Large scale transfection of mouse L-cells by electropermeabilization
43. Analysis of mitochondrial morphology and function with novel fixable fluorescent stains