Influence of multidrug resistance (MDR) proteins at the blood-brain barrier on the transport and brain distribution of enaminone anticonvulsants

Journal of Pharmaceutical Sciences

Volumn 90, Issue 10, 2001, Pages 1540-1552

  Cox, Donna S ^a   Scott, Kenneth R ^b   Gao, Huanling ^a   Raje, Sangeeta ^a   Eddington, Natalie D ^b  

^a UNIVERSITY OF MARYLAND SCHOOL OF PHARMACY   (United States)

^b HOWARD UNIVERSITY   (United States)

Author keywords

BBB; Brain distribution; Enaminones; Epilepsy; MRP; P glycoprotein

Indexed keywords

ANTICONVULSIVE AGENT; GLYCOPROTEIN P; METHYL 4 [4' (CHLOROPHENYL)AMINO] 6 METHYL 2 OXO 3 CYCLOHEXANE 1 CARBOXYLATE; MULTIDRUG RESISTANCE PROTEIN; PROBENECID; RHODAMINE 123; UNCLASSIFIED DRUG; VERAPAMIL;

ANIMAL CELL; ARTICLE; BLOOD BRAIN BARRIER; CATTLE; CONTROLLED STUDY; DRUG DISTRIBUTION; DRUG PROTEIN BINDING; DRUG TRANSPORT; ENDOTHELIUM CELL; EPILEPSY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; MALE; MOUSE; NONHUMAN; REGULATORY MECHANISM;

EID: 0034762283     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1002/jps.1104     Document Type: Article

References (35)

1. CNS drug design based on principles of blood-brain barrier transport
2. Biochemistry of multidrug resistance mediated by the multidrug transporter
3. Biochemical, cellular, and pharmacological aspects of the multidrug transporter
4. A multidrug resistance transporter from human MCF-7 breast cancer cell
5. The human multi-drug resistance-associated protein MRP is a plasma membrane drug-efflux pump
6. Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines
7. MRP3, an organic anion transporter able to transport anti-cancer drugs
8. A family of drug transporters: The multidrug resistance-associated proteins
9. Expression of various multidrug resistance-associated protein (MRP) homologues in brain microvessel endothelial cells
10. Absence of the mdr1a P-glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A
11. P-Glycoprotein, a gatekeeper in the blood-brain barrier
12. Overexpression of the gene encoding the multidrug resistance associated protein results in increased ATP-dependent glutathione S-conjugates transport
13. Multidrug resistance protein 1 protects the oropharyngeal mucosal layer and the testicular tubules against drug-induced damage
14. Expression of the MRP gene-encoded conjugate export pump in liver and its selective absence from the canalicular membrane in transport-deficient mutant hepatocytes
15. Expression of multidrug resistance-associated protein (MRP) in brain microvessel endothelial cells
16. Multidrug resistance protein 1 protects the choroid plexus epithelium and contributes to the blood-cerebrospinal fluid barrier
17. P-Glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs
18. Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug transporting) P-glycoproteins
19. MDR1 gene expression in brain of patients with medically intractabel epilepsy
20. Tuberous sclerosis associated with MDR1 gene expression and drug-resistant epilepsy
21. Synthesis and anticonvulsant activity of enaminones. 3. Investigations on 4′-, 3′-, and 2′-substituted polysubstituted anilino compounds, sodium channel binding studies, and toxicity evaluations
22. Enaminones-versatile therapeutic pharmacophores. Further advances
23. Characterization of an in vitro blood-brain barrier model system for studying drug transport and metabolism
24. The effects of verapamil on the transport of peptides across the blood-brain barrier in rats: Kinetic evidence for an apically polarized efflux mechanism
25. Functional expression of P-glycoprotein and multidrug resistance-associated protein (Mrp1) in primary cultures of rat astrocytes
26. The role of probenecid-sensitive organic acid transport in the pharmacokinetics of N-methyl-D-aspartate receptor antagonists acting at the glycine-site: Microdialysis and maximum electroshock seizure studies
27. Determination of the enaminone, DM5, an anti-epileptic agent in mouse plasma and brain tissue by high performance liquid chromatography with ultraviolet detection
28. Contribution of probenecid-sensitive anion transport processes at the brain capillary endothelium and choroid plexus to the efficient efflux of valproic acid from the central nervous system
29. Transport properties of the multidrug resistance-associated protein (MRP) in human tumor cells
30. In situ biochemical demonstrations that P-glycoprotein is a drug efflux pump with broad specificity
31. Use of rhodamine 123 to examine the functional activity of P-glycoprotein in primary cultured brain microvessel endothelial cell monolayers
32. Comparison of staurosporine and four analogues: Their effects on growth, rhodamine 123 retention and binding to P-glycoprotein in multidrug resistant MCF-7/Adr cells
33. Combinations of P-glycoprotein blockers, verapamil, PSC833, and cremophor act differently on the multidrug resistance associated protein (MRP) and on P-glycoprotein
34. Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs
35. Quinolinic acid is extruded from the brain by a probenecid-sensitive carrier system: A quantitative analysis