Nitric oxide inhibitors ameliorate indomethacin-induced enteropathy in rats

Digestive Diseases and Sciences

Volumn 46, Issue 11, 2001, Pages 2536-2541

  Parasher, G ^a   Frenklakh, L ^a   Goodman, D R ^a   Siddiqui, T ^a   Nandi, J ^a   Levine, R A ^a  

^a State University of New York Upstate Medical University: College of Medicine   (United States)

Author keywords

Intestinal ulceration; Myeloperoxidase; Nitric oxide synthase

Indexed keywords

AMINOGUANIDINE; BICARBONATE; GUANIDINOETHYLDISULFIDE; INDOMETACIN; MYELOPEROXIDASE; N (3 AMINOMETHYL)BENZYLACETAMIDINE; N [3 (AMINOMETHYL)BENZYL]ACETAMIDINE; NITRATE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; NITRITE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG INDUCED DISEASE; ENTEROPATHY; ENZYME ACTIVITY; ENZYME INHIBITION; INTESTINE ULCER; MALE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; RAT; SMALL INTESTINE MUCOSA; ULCER HEALING; WESTERN BLOTTING;

AMIDINES; ANIMALS; BENZYLAMINES; BLOTTING, WESTERN; ENZYME INHIBITORS; GUANIDINES; INDOMETHACIN; INTESTINAL DISEASES; INTESTINAL MUCOSA; MALE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; PEROXIDASE; RATS; RATS, SPRAGUE-DAWLEY; ULCER;

EID: 0034761563     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1012304710187     Document Type: Article

References (21)

1. Role of inducible nitric oxide synthase expression and peroxynitrite formation in guinea pig ileitis
2. Resolving the nitric oxide paradox in acute tissue damage
3. Nitric oxide III. A molecular prelude to inflammation
4. Nitric oxide and inflammatory bowel diseases
5. Experimental colitis is ameliorated by inhibition of nitric oxide synthase activity
6. Nitric oxide 1. Physiological chemistry of nitric oxide and its metabolite: Implications in inflammation
7. Nitric oxide. V. Therapeutic potential of nitric oxide donors and inhibitors
8. Enhanced colonic nitric oxide generation and nitric oxide synthase activity in ulcerative colitis and Crohn's disease
9. Expression of NOS II and its role in experimental small bowel ulceration in rats
10. Mode of food intake reduction in Lewis rats with indomethacin-induced ulcerative ileitis
11. Intravenous nucleoside and a nucleotide promote healing of small bowel ulcers in experimental enterocolitis
12. Dual action of nitric oxide in pathogenesis of indomethacin-induced small intestinal ulceration in rats
13. Nitric oxide, superoxide radicals and mast cells in pathogenesis of indomethacin-induced small intestinal lesions in rats
14. Role of nitric oxide and platelet-activating factor in the initiation of indomethacin-provoked intestinal inflammation in rats
15. Induction of nitric oxide synthase and microvascular injury in the rat jejunum provoked by indomethacin
16. Side effects of nonsteroid antiinflammatory drugs on the small and large intestine in humans
17. 1400W is a slow, tight binding, and highly selective inhibitor of inducible nitric-oxide synthase in vitro and in vivo
18. G-mono-methyl-arginine in vitro and in vivo
19. Assessment of leukocyte involvement during ischemia and reperfusion of intestine
20. Peroxynitrite-induced rat colitis: A new model of colonic inflammation
21. Nonsteroidal antiinflammatory drug enteropathy in rats: Role of permeability, bacteria and enterohepatic circulation