Pravastatin, a 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitor, attenuates renal injury in an experimental model of ischemia-reperfusion

Journal of Surgical Research

Volumn 101, Issue 1, 2001, Pages 79-84

  Joyce, Myles ^a   Kelly, Cathal ^a   Winter, Des ^a   Chen, Gang ^a   Leahy, Austin ^a   Bouchier Hayes, David ^a  

^a BEAUMONT HOSPITAL   (Ireland)

Author keywords

Acute renal failure; Constitutive endothelial nitric oxide synthase; HMG CoA reductase inhibitor; Ischemia reperfusion; Nitric oxide

Indexed keywords

HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; NITRIC OXIDE; PRAVASTATIN; PROTEIN;

ACUTE KIDNEY FAILURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; GLOMERULUS FILTRATION RATE; HISTOPATHOLOGY; KIDNEY ISCHEMIA; MALE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN URINE LEVEL; RAT; REPERFUSION INJURY; URINARY EXCRETION;

EID: 0034758721     PISSN: 00224804     EISSN: None     Source Type: Journal    
DOI: 10.1006/jsre.2001.6256     Document Type: Article

References (47)

1. Renal failure after operation for abdominal aortic aneurysm
2. Acute renal failure following surgery for abdominal aortic aneurysm
3. Risk factors for postoperative death following elective surgical repair of abdominal aortic aneurysm: Results from the UK Small Aneurysm Trial
4. The impact of ischaemia/reperfusion injury on specific and non-specific early and late chronic events after organ transplantation
5. Ischemic injury during syngeneic rat kidney transplantation results in trafficking of inflammatory cells into the kidney and expression of major histocompatibility and adhesion molecules on renal tubule cells and capillary endothelium
6. Delayed graft function, acute rejection, and outcome after cadaver renal transplantation
7. Early function as the principal correlate of graft survival: A multivariate analysis of 200 cadaveric renal transplants treated with a protocol incorporating antilymphocyte globulin and cyclosporine
8. Mechanisms of ischemic acute renal failure
9. Hyperplasia, hypertrophy, and phenotypic alterations in the distal nephron after acute proximal tubular injury in the rat
10. Dissociation of tubular cell detachment and tubular cell death in clinical and experimental "acute tubular necrosis".
11. Inhibition of cholesterol synthesis in vitro and in vivo by ML-236A and ML-236B, competitive inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductase
12. Regulation of the mevalonate pathway
13. Randomized trial of cholesterol lowering in 4444 patients with coronary heart disease: The Scandinavian Simvastatin Survival Study (4S)
14. Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia: West of Scotland Coronary Prevention Study
15. Reduction in cardiovascular events during pravastatin therapy
16. Statins do more than just lower cholesterol
17. Vascular effects of statins in stroke
18. Antiatherothrombotic properties of statins: Implications for cardiovascular event reduction
19. Upregulation of endothelial nitric oxide synthase by HMG CoA Reductase inhibitors
20. Pravastatin sodium activates endothelial nitric oxide synthase independent of its cholesterol-lowering actions
21. Nitric oxide is responsible for flow-dependent dilation of human peripheral conduit arteries in vivo
22. Role of nitric oxide in cardiovascular disease: Focus on the endothelium
23. Impaired nitric oxide-mediated vasodilation in patients with non-insulin dependent diabetes
24. Control of regional blood flow by endothelium-derived nitric oxide
25. Importance of NO/EDRF for glomerular and tubular function: Studies in the isolated perfused rat kidney
26. Thermotolerence attenuates ischaemia-reperfusion induced renal injury and increased expression of ICAM- 1
27. L-arginine reduces tubular cell injury in acute post-ischemic renal failure
28. Postischemic renal injury is mediated by neutrophils and leukotrienes
29. Oxidized low-density lipoprotein decreases the expression of endothelial nitric oxide synthase
30. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine
31. Biochemistry of nitric oxide and its redox-activated forms
32. Endothelial derived relaxing factor controls renal haemodynamics in the normal rat kidney
33. Role of nitric oxide in the hypoxemia-induced renal dysfunction of the newborn rabbit
34. Renal ischemia and reperfusion impair endothelium-dependent vascular relaxation
35. Inhibition of endothelial derived relaxing factor (EDRF) aggravates ischemic acute renal failure in anesthetized rats
36. Role of L-arginine derived NO in ischemic acute renal failure in the rat
37. Role of nitric oxide in renal haemodynamic abnormalities of cyclosporin nephrotoxicity
38. Effect of inhibition of nitric oxide synthase in acute renal failure due to endotoxin shock in dogs
39. Glucagon and prostaglandins are mediators of amino-acid induced rise in renal haemodynmics
40. Atorvostatin increases ecNOS levels in human platelets of hyperlipidemic subjects
41. 3-Hydroxy-3-methylglutaryl-CoA reductase inhibitors attenuate vascular smooth muscle proliferation by preventing rho GTPase-induced downregulation of p27(Kipl)
42. Simvastain inhibits leucocyte-endothelial cell interactions and protects against inflammatory processes in normocholesterolemic rats
43. Simvastatin, an HMG-coenzyme A reductase inhibitor, improves endothelial function within 1-month
44. Stroke protection by 3-hydroxy 3-methylglutaryl (HMG)-CoA reductase inhibitors mediated by endothelial nitric oxide synthase
45. Simvastatin preserves the ischemic-reperfused myocardium in normocholesterolemic rat hearts