Design and synthesis of carboxylate inhibitors for matrix metalloproteinases

Chemical and Pharmaceutical Bulletin

Volumn 49, Issue 10, 2001, Pages 1272-1279

  Fujisawa, T ^a   Katakura, S ^a   Odake, S ^a   Morita, Y ^a   Yasuda, J ^a   Yasumatsu, I ^a   Morikawa, T ^a  

^a FUJI CHEMICAL INDUSTRIES LTD   (Japan)

Author keywords

Carboxylate; Computerized drug design; Human fibroblast collagenase; Inhibitor; Stromelysin 1

Indexed keywords

2,3 DIAMINOPROPIONIC ACID; 3 (N ALPHA BENZOYLGLYCYLPROLYLLEUCYLAMINO) 2 (4 METHOXYBENZYLOXYCARBONYLAMINO)PROPIONIC ACID; 3 (N ALPHA BENZOYLGLYCYLPROLYLLEUCYLAMINO) 2 (4 TOLUENESULFONYLAMINO)PROPIONIC ACID; 3 (N ALPHA BENZOYLGLYCYLPROLYLLEUCYLAMINO) 2 (BENZYLOXYCARBONYLAMINO)PROPIONIC ACID; 3 (N ALPHA BENZOYLGLYCYLPROLYLLEUCYLAMINO) 2 (BENZYLSULFONYLAMINO)PROPIONIC ACID; 3 (N ALPHA BENZOYLGLYCYLPROLYLLEUCYLAMINO) 2 (TERT BUTYLOXYCARBONYLAMINO)BUTANOIC ACID; 3 (N ALPHA BENZOYLGLYCYLPROLYLLEUCYLAMINO) 2 AMINOPROPIONIC ACID; BATIMASTAT; BUTYRIC ACID DERIVATIVE; CARBAMIC ACID DERIVATIVE; CARBOXYLIC ACID DERIVATIVE; CIPEMASTAT; MARIMASTAT; MATRIX METALLOPROTEINASE INHIBITOR; PRINOMASTAT; STROMELYSIN; SULFONAMIDE; UNCLASSIFIED DRUG;

ARTICLE; COMPUTER PROGRAM; DRUG DESIGN; DRUG EFFICACY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; STRUCTURE ACTIVITY RELATION;

CARBOXYLIC ACIDS; CHELATING AGENTS; DRUG DESIGN; ENZYME INHIBITORS; INDICATORS AND REAGENTS; MATRIX METALLOPROTEINASE 1; MATRIX METALLOPROTEINASE 3; MATRIX METALLOPROTEINASES; MODELS, MOLECULAR; PEPTIDES; ZINC;

EID: 0034757396     PISSN: 00092363     EISSN: None     Source Type: Journal    
DOI: 10.1248/cpb.49.1272     Document Type: Article

References (28)