Transcription factor decoy oligodeoxynucleotides to nuclear factor-κB inhibit reverse passive Arthus reaction in rat

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 364, Issue 5, 2001, Pages 422-429

  D'Acquisto, F ^a   Ianaro, A ^a   Ialenti, A ^a   Maffia, P ^a   Maiuri, M C ^a   Carnuccio, R ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

Cyclooxygenase 2; Inducible nitric oxide synthase; Nuclear factor B; Reverse passive Arthus reaction; Transcription factor decoy

Indexed keywords

AMMONIUM PYRROLIDINE DITHIOCARBAMATE; CYCLOOXYGENASE 2; ENZYME INHIBITOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NITRIC OXIDE SYNTHASE; OLIGODEOXYNUCLEOTIDE; PROTEIN P50; PROTEIN SN 50; PROTEIN SUBUNIT; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTHUS PHENOMENON; ARTICLE; CELL MEMBRANE PERMEABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA BINDING; DRUG BINDING; DRUG INHIBITION; ENZYME ACTIVATION; ENZYME INHIBITION; MALE; MUTANT; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PROTEIN EXPRESSION; RAT; SOFT TISSUE;

ANALYSIS OF VARIANCE; ANIMALS; ANTIOXIDANTS; ARTHUS REACTION; CYCLOOXYGENASE 2; DNA; DRUG INTERACTIONS; ISOENZYMES; MALE; NF-KAPPA B; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PYRROLIDINES; RATS; RATS, WISTAR; SKIN; THIOCARBAMATES; TRANSCRIPTION FACTORS;

EID: 0034752043     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002100100472     Document Type: Article

References (49)

1. Immunosuppression by glucocorticoids: Inhibition of NF-κB activity through induction of IκB synthesis
2. NF-κB: Ten years after
3. Function and activation of NF-κB in the immune system
4. Immune complexes and inflammation. A study of the activity of anti-inflammatory drugs in the reverse passive Arthus reaction in the rat
5. 4-Trifluoromethyl derivatives and its main metabolite 2-hydroxy-4-trifluoromethylbenzoic acid, are potent inhibitors of nuclear factor kappa B activation
6. Regulation of gene expression with double stranded phosphorothioate oligonucleotides
7. Measurement of cutaneous inflammation: Estimation of neutrophil content with an enzyme marker
8. Pathways to inflammation induced by immune complexes: Development of the Arthus reaction
9. Activation of nuclear transcription factor κB in rat carrageenin-induced pleurisy
10. Nuclear factor-κB mediates inducible nitric oxide synthase protein expression in carrageenin-induced rat pleurisy
11. Inhibition of nuclear factor-κB prevents the loss of vascular tone in lipopolysaccharide-treated rats
12. Local administration of transcription factor decoy oligonucleotides to nuclear factor-κB prevents carrageenin-induced inflammation in rat hind paw
13. Transcriptional regulation of human inducible nitric oxide synthase (NOS2) gene by cytokines: Initial analysis of the human NOS2 promoter
14. Dexamethasone suppresses iNOS gene expression by upregulating I-kappa B alpha and inhibiting NF-kappa B
15. Studies of mediators of the acute inflammatory response induced in rats in different sites by carrageenin and turpentine
16. Inhibition of cyclooxygenase-2 expression by 4-trifluoromethyl derivates of salicylate, triflusal, and its deacetylated metabolite, 2-hydroxy-4-trifluoromethylbenzoic acid
17. Transcriptional inhibition of the inducible nitric oxide synthase gene by competitive binding of NF-κB/Rel proteins
18. Measurement of cutaneous microvascular exudates using Evans Blue
19. Modulation of acute inflammation by endogenous nitric oxide
20. Nitric oxide inhibits neutrophil infiltration in the reverse passive Arthus reaction in rat skin
21. Inhibition of NF-κB by sodium salicylate and aspirin
22. Inhibition of nuclear translocation of transcription factor NF-kappa B by a synthetic peptide containing a cell membrane-permeable motif and nuclear localisation sequence
23. Therapeutic application of transcription factor decoy oligonucleotides
24. Signal transduction through NF-κB
25. Synthesis of nitric oxide from L-arginine by neutrophils
26. NF-κB activation provides the potential link between inflammation and hyperplasia in arthritic joint
27. Time-course of phospholipase A2, eicosanoid release and cellular accumulation in rat immunological air pouch inflammation
28. Reactive oxygen species and iron - A dangerous partnership in inflammation
29. Tissue injury caused by deposition of immune complexes is L- arginine dependent
30. Protective effects of inhibitors of nitric oxide in immune complexes-induced vasculitis
31. Role of adhesion glycoproteins CD-18 and intercellular adhesion molecules in complement-mediated reactions of rabbit skin
32. Novel inhibitor of cytokine-induced IκBα phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo
33. 2 formation
34. Induction of cytokines and ICAM-1 by proinflammatory cytokines in primary rheumatoid synovial fibroblast and inhibition by N-acetyl-L-cysteine and aspirin
35. Activation of transcription factor NF-κB in experimental glomerulonephritis in rats
36. Role of transcriptional activation of IκBα in mediation of immunosuppression by glucocorticoids
37. Improved method for quantification of tissue PMN accumulation measured by myeloperoxidase activity
38. Hypoxia induces cyclooxygenase-2 via the NF-κB p65 transcription factor in human vascular endothelial cells
39. The roles of hydrogen peroxide and superoxide as messenger in the activation of transcription factor NF-κB
40. Dithiocarbamate as potent inhibitors of nuclear factor κB activation in intact cells
41. Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain
42. Transcription factor decoy approach to decipher the role of NF-κB in oncogenesis
43. Characterisation and hormonal regulation of the promoter of rat prostaglandin endoperoxide synthase 2 gene in granulosa cells. Identification of functional and protein-binding regions
44. Role of prostaglandins and nitric oxide in acute inflammatory reactions in guinea-pig skin
45. Studies on the mechanisms involved in the inflammatory response in a reversed passive Arthus reaction in guinea-pig skin: Contribution of neutrophils and endogenous mediators
46. Suppressed severity of collagen-induced arthritis by in vivo transfection of nuclear factor kappaB decoy oligodeoxynucleotides as a gene therapy
47. Role of prostaglandin-mediated vasodilation in inflammation
48. Role of transcription factor NF-κB/Rel in induction of nitric oxide
49. Transcriptional roles of nuclear factor κB and nuclear factor-interleukin-6 in the tumor necrosis factor α-dependent induction of cyclooxygenase-2 in MC3T3-E1 cells