Genotypic and phenotypic evidence of different drug-resistance mutation patterns between B and non-B subtype isolates of human immunodeficiency virus type 1 found in Brazilian patients failing HAART

Virus Genes

Volumn 23, Issue 2, 2001, Pages 193-202

  Caride, E ^a   Hertogs, K ^b   Larder, B ^c   Dehertogh, P ^b   Brindeiro, R ^a   Machado, E ^a,d   De Sa C A M ^e   Eyer Silva, W A ^e   Samuel Sion, F ^e   Passioni, L F C ^e   Menezes, J A ^e   Calazans, A R ^a   Tanuri, A ^a  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^b Virco BVBA   (Belgium)

^c Virco UK Ltd   (United Kingdom)

^d HOSPITAL DOS SERVIDORES DO ESTADO   (Brazil)

^e HOSPITAL UNIVERSITÁRIO GAFFRÉE E GUINLE   (Brazil)

Author keywords

Genotyping; HIV 1; Phenotyping; Protease; Subtype

Indexed keywords

ANTIRETROVIRUS AGENT; GLYCINE; INDINAVIR; ISOLEUCINE; LEUCINE; METHIONINE; PHENYLALANINE; POL PROTEIN; PROTEINASE INHIBITOR; RITONAVIR; SAQUINAVIR; VALINE;

ARTICLE; BRAZIL; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENE AMPLIFICATION; GENE MUTATION; GENE SEQUENCE; GENETIC ANALYSIS; GENOTYPE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; PROVIRUS; VIRAL GENETICS; VIRUS RESISTANCE; VIRUS STRAIN;

AMINO ACID SEQUENCE; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; DRUG RESISTANCE, MICROBIAL; GENOTYPE; HIV INFECTIONS; HIV-1; HUMANS; MOLECULAR SEQUENCE DATA; MUTATION; PHENOTYPE; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 0034751827     PISSN: 09208569     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1011812810397     Document Type: Article

References (43)

1. HIV-1 protease inhibitors: Their development, mechanism of action and clinical potential
2. Human immunodeficiency virus type 1 protease inhibitors
3. A preliminary study of ritonavir an inhibitor of HIV-1 protease, to treat HIV-1 infection
4. Treatment of human immunodeficiency virus infection with saquinavir, zidovudine, and zalcitabine
5. Antiretrovial therapy for HIV infection
6. Saquinavir/zidovudine combination in patients with advanced HIV infection and no prior antiretroviral therapy: CD4+ lymphocyte/plasma RNA changes, and emergence of HIV strains with reduced phenotypic sensitivity
7. Clinical progression and virological failure on highly active antiretroviral therapy in HIV-1 patients: A prospective cohort study
8. Multiple concurrent reverse transcriptase and protease mutations multidrug resistance of HIV-1 isolates from heavily treated patients
9. Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy
10. Quantifying residual HIV-1 replication in patients receiving combination antiretroviral therapy
11. In vivo emergence of HIV-1 variant resistant to multiple protease inhibitors
12. Development of drug resistance to HIV-1 protease inhibitors
13. V3 region polymorphism in HIV-1 from Brazil: Prevalence of subtype B strains divergent from North American/European prototype and detection of subtype
14. Distribution of HIV-1 subtypes seen in an AIDS clinic in Sao Paulo City, Brazil
15. HIV-1 subtypes among blood donors from Rio de Janeiro, Brazil
16. Horizontal and vertical transmission of human immunodeficiency virus type 1 dual infections caused by viruses of subtypes B and C
17. HIV-1 patients may harbor viruses of different phylogenetic subtypes: Implications for the evolution of the HIV/AIDS pandemic
18. Dual and recombinant infections: An integral part of the HIV-1 epidemic in Brazil
19. HIV-1 genetic diversity
20. Design and evaluation of human immunodeficiency virus type 1 RNA assay using nucleic acid sequence-based amplification technology able to quantify both group M and O viruses by using the long terminal repeat as target
21. CLUSTAL W: Improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice
22. The neighbor-joining method: A new method for reconstructing phylogenetic tress
23. A rapid method for simultaneous detection of phenotypic resistance to inhibitors of protease and reverse transcriptase in recombinant human immunodeficiency virus type 1 isolates from patients treated with antiretroviral drugs
24. Genetic variation and susceptibilities to protease inhibitors among subtypes B and F isolates in Brazil
25. Quantification of HIV-1 RNA in plasma predicts outcome after seroconversion
26. Human immunodeficiency virus reverse transcriptase and protease sequence database
27. Analysis of HIV type 1 protease and reverse transcriptase in antiretroviral drug-naïve Ugandan adult
28. Protease sequences from HIV-1 group M subtypes A-H reveal distinct amino acid mutation patterns associated with protease resistance in protease inhibitor-naive individuals
29. Genetic diversity of protease and reverse transcriptase sequences in non-subtype-B human immunodeficiency virus type 1 strains: Evidence of many minor drug resistance mutation in treatment-naïve patients
30. Cross-resistance analysis of human immunodeficiency virus type 1 variants individually selected for resistance to five different protease inhibitors
31. Resistance-associated loss of viral fitness in human immunodeficiency virus type 1: Phenotypic analysis of protease and gag coevolution in protease inhibitor-treated patients
32. Sequence diversity of the reverse transcriptase of human immunodeficiency virus type 1 from untreated Brazilian individuals
33. Naturally occurring decreased susceptibility of HIV-1 subtypes G to protease inhibitors
34. In vivo sequence diversity of the protease of human immunodeficiency virus type 1: Presence of protease inhibitor-resistant variants in untreated subjects
35. Drug susceptibility of subtypes A, B, C, D and E human immunodeficiency virus type 1 primary isolates
36. Susceptibility of human immunodeficiency virus type 1 group O isolates to antiretroviral agents: In vitro phenotypic and genotypic analyses
37. Mutation in naïve and treated clade C patients
38. Increasing diversity of HIV-1M serotypes in French blood donors over a 10-year period (1985-1995)
39. Detection of diverse HIV-1 genetic subtypes in the USA
40. Longstanding presence in Belgians of multiple non-B HIV-1 subtypes
41. The emerging genetic diversity of HIV: The importance of global surveillance for diagnostics, research, and prevention
42. Antiretroviral drug resistance testing in adult HIV-1 infection: Recommendation of an international AIDS society-USA panel