The regulation of alpha chemokines during HIV-1 infection and leukocyte activation: Relevance for HIV-1-associated dementia

Journal of Neuroimmunology

Volumn 120, Issue 1-2, 2001, Pages 112-128

  Poluektova, Larisa ^a,b   Moran, Tim ^a,b   Zelivyanskaya, Marina ^a,b   Swindells, Susan ^c   Gendelman, Howard E ^a   Persidsky, Yuri ^a,b  

^a NEBRASKA MEDICAL CENTER   (United States)

^b UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^c NONE   (United States)

Author keywords

Brain; Chemotaxis; HIV 1 infection; Lymphocyte; Monocyte macrophage

Indexed keywords

ALPHA CHEMOKINE; CHEMOATTRACTANT; CHEMOKINE RECEPTOR CXCR3; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; MONOKINE;

ADULT; AGED; ARTICLE; ASTROCYTE; CHILD; CLINICAL ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DEMENTIA; ENZYME REGULATION; FETUS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN TISSUE; IMMUNE RESPONSE; IMMUNOSTIMULATION; LEUKOCYTE ACTIVATION; LYMPHOCYTE; LYMPHOCYTE MIGRATION; MACROPHAGE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; T LYMPHOCYTE; TARGET CELL; VIRUS REPLICATION;

ADULT; AGED; AIDS DEMENTIA COMPLEX; ASTROCYTES; BRAIN; CELLS, CULTURED; CHEMOKINES, CXC; CHEMOTAXIS, LEUKOCYTE; CHILD; CHILD, PRESCHOOL; FETUS; HIV-1; HUMANS; IMMUNITY, CELLULAR; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; INTERFERON TYPE II; LEUKOCYTES; LYMPHOCYTE ACTIVATION; LYMPHOCYTES; MACROPHAGES; MIDDLE AGED; RECEPTORS, CHEMOKINE; RNA, MESSENGER;

EID: 0034751798     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-5728(01)00413-1     Document Type: Article

References (91)

1. Brain viral burden in HIV infection
2. Rate and severity of HIV-associated dementia (HAD): Correlations with Gp41 and iNOS
3. Relative efficiency of microglia, astrocytes, dendritic cells and B cells in naive CD4+ T cell priming and Th1/Th2 cell restimulation
4. Chemokines and the inflammatory response to viral infection in the central nervous system with a focus on lymphocytic choriomeningitis virus
5. CCR5(+) and CXCR3(+) T cells are increased in multiple sclerosis and their ligands MIP-1alpha and IP-10 are expressed in demyelinating brain lesions
6. HIV in the brain: Pathology and neurobehavioral consequences
7. The level of human immunodeficiency virus (HIV) type 1 RNA in cerebrospinal fluid as a marker of HIV encephalitis
8. Increased expression of interferon-gamma in hyperplastic lymph nodes from HIV-infected patients
9. The relationship between AIDS dementia complex and the presence of macrophage tropic and non-syncytium inducing isolates of human immunodeficiency virus type 1 in the cerebrospinal fluid
10. Human immunodeficiency virus (HIV)-induced disease of the central nervous system: Pathology and implications for pathogenesis
11. Dual function of a human immunodeficiency virus (HIV)-specific cytotoxic T-lymphocyte clone: Inhibition of HIV replication by noncytolytic mechanisms and lysis of HIV-infected CD4+ cells
12. Leukocyte infiltration, neuronal degeneration, and neurite outgrowth after ablation of scar-forming, reactive astrocytes in adult transgenic mice
13. Distinct biological and serological properties of human immunodeficiency viruses from the brain
14. Cytokine mRNA expression in mononuclear cells from different tissues during acute SIVmac251 infection of macaques
15. Interferon-inducible T cell alpha chemoattractant (I-TAC): A novel non-ELR CXC chemokine with potent activity on activated T cells through selective high affinity binding to CXCR3
16. An infectious molecular clone of an unusual macrophage-tropic and highly cytopathic strain of human immunodeficiency virus type 1
17. Acute AIDS retrovirus infection. Definition of a clinical illness associated with seroconversion
18. Weak anti-HIV CD8(+) T-cell effector activity in HIV primary infection
19. Early viral brain invasion in iatrogenic human immunodeficiency virus infection
20. Cytokine response in multiple lymphoid tissues during the primary phase of feline immunodeficiency virus infection
21. Cerebrospinal fluid human immunodeficiency virus type 1 RNA levels are elevated in neurocognitively impaired individuals with acquired immunodeficiency syndrome
22. Human immunodeficiency virus type 1 infection of the nervous system: Pathogenetic mechanisms
23. Immunocytochemical characterization of the macrophage and lymphocyte infiltrate in the brain in six cases of human encephalitis of varied aetiology
24. Interferon-gamma protects primary monocytes against infection with human immunodeficiency virus type 1
25. HuMig: A new human member of the chemokine family of cytokines
26. Virus isolation from and identification of HTLV-III/LAV-producing cells in brain tissue from a patient with AIDS
27. Immunopathogenesis of human immunodeficiency virus infection in the central nervous system
28. The neuropathogenesis of the AIDS dementia complex
29. Suppression of inflammatory neurotoxins by highly active antiretroviral therapy in human immunodeficiency virus-associated dementia
30. Mononuclear phagocytes differentiation, activation and viral infection regulate matrix metalloproteinase expression: Implications for HIV-1-associated dementia
31. Chemokines and chemokine receptors in CNS pathology
32. Central nervous system chemokine mRNA accumulation follows initial leukocyte entry at the onset of acute murine experimental autoimmune encephalomyelitis
33. Immunocytochemical quantitation of human immunodeficiency virus in the brain: Correlation with dementia
34. Pathology of the central nervous system in 40 cases of acquired immune deficiency syndrome (AIDS)
35. Early brain changes in HIV infection: Neuropathological study of 11 HIV seropositive, non-AIDS cases
36. Kinetics of cytokine expression during primary human immunodeficiency virus type 1 infection
37. Efficient synthesis of viral nucleic acids following monocyte infection by HIV-1
38. T cell-tropic HIV gp120 mediates CD4 and CD8 cell chemotaxis through CXCR4 independent of CD4: Implications for HIV pathogenesis
39. Epidemiology of HIV encephalopathy in the United States
40. Detection of a vigorous HIV-1-specific cytotoxic T lymphocyte response in cerebrospinal fluid from infected persons with AIDS dementia complex
41. Human immunodeficiency virus type 1-specific cytotoxic T lymphocytes release gamma interferon, tumor necrosis factor alpha (TNF-alpha), and TNF-beta when they encounter their target antigens
42. Detection of AIDS virus in macrophages in brain tissue from AIDS patients with encephalopathy
43. Identification of a T cell chemotactic factor in the cerebrospinal fluid of HIV-1-infected individuals as interferon-gamma inducible protein 10
44. Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome
45. Dual infection of the central nervous system by AIDS viruses with distinct cellular tropisms
46. HIV-1 protein Tat induces apoptosis of hippocampal neurons by a mechanism involving caspase activation, calcium overload, and oxidative stress
47. Induction of the chemokines interleukin-8 and IP-10 by human immunodeficiency virus type 1 Tat in astrocytes
48. Dynamic regulation of alpha- and beta-chemokine expression in the central nervous system during mouse hepatitis virus-induced demyelinating disease
49. HIV coat protein gp120 induces soluble neurotoxins in culture medium
50. Cutting edge: The T cell chemoattractant IFN-inducible protein 10 is essential in host defense against viral-induced neurologic disease
51. Chemokine receptor specific for IP10 and mig: Structure, function, and expression in activated T-lymphocytes [see comments]
52. The CXC-chemokine, H174: Expression in the central nervous system
53. Gamma-interferon transcriptionally regulates an early-response gene containing homology to platelet proteins
54. An automated colorimetric microassay for neurotrophic factors
55. Direct induction of interferon-gamma-and interferon-alpha/beta-inducible genes by double-stranded RNA
56. Characterization of the cellular and cytokine response in the central nervous system following Semliki Forest virus infection
57. Persistent high frequency of human immunodeficiency virus-specific cytotoxic T cells in peripheral blood of infected donors
58. Presence of HLA-C-restricted cytotoxic T-lymphocyte responses in long-term nonprogressors infected with human immunodeficiency virus
59. The numbers of immune-competent macrophages and replication competence define the severity of HIV-1 encephalitis in SCID mice
60. Quantitation of HIV-1-specific cytotoxic T lymphocytes and plasma load of viral RNA
61. Cytokine regulation of CC and CXC chemokine expression by human astrocytes
62. Production of high-titer helper-free retroviruses by transient transfection
63. An analysis of HIV-1-associated inflammatory products in brain tissue of humans and SCID mice with HIV-1 encephalitis
64. A model for monocyte migration through the blood-brain barrier during HIV-1 encephalitis
65. Microglial and astrocyte chemokines regulate monocyte migration through the blood-brain barrier in human immunodeficiency virus-1 encephalitis
66. The chemokine receptor CXCR3 mediates rapid and shear-resistant adhesion-induction of effector T lymphocytes by the chemokines IP-10 and Mig
67. HIV-1-specific CD4+ T cells are detectable in most individuals with active HIV-1 infection, but decline with prolonged viral suppression
68. AIDS dementia complex and HIV-1 brain infection: A pathogenetic framework for treatment and evaluation
69. The chemokine receptors CXCR3 and CCR5 mark subsets of T cells associated with certain inflammatory reactions
70. Chemokine receptor responses on T cells are achieved through regulation of both receptor expression and signaling
71. Astrocyte expression of mRNA encoding cytokines IP-10 and JE/MCP-1 in experimental autoimmune encephalomyelitis
72. Virus-induced cytokines regulate circulating lymphocyte levels during primary SIV infections
73. Peripheral immune activation in HIV-1 associated dementia: Elevated plasma levels of soluble CD14 and TNF-α receptor two
74. Switch in chemokine receptor expression upon TCR stimulation reveals novel homing potential for recently activated T cells
75. Chemokines and receptors in HIV encephalitis
76. Chemokine expression in simian immunodeficiency virus-induced AIDS encephalitis
77. Chemokine gene expression in astrocytes of Borna disease virus-infected rats and mice in the absence of inflammation
78. Control of viremia in simian immunodeficiency virus infection by CD8+ lymphocytes
79. Phenotypic heterogeneity of cerebrospinal fluid-derived HIV-specific and HLA-restricted cytotoxic T-cell clones
80. Immunohistochemical changes and PCR detection of HIV provirus DNA in brains of asymptomatic HIV-positive patients
81. Protective role of the virus-specific immune response for development of severe neurologic signs in simian immunodeficiency virus-infected macaques
82. Interferons and interferon (IFN)-inducible protein 10 during highly active anti-retroviral therapy (HAART) - Possible immunosuppressive role of IFN-alpha in HIV infection
83. HIV-1 Nef mediates lymphocyte chemotaxis and activation by infected macrophages
84. Human immunodeficiency virus-specific circulating CD8 T lymphocytes have down-modulated CD3zeta and CD28, key signaling molecules for T-cell activation
85. CD8+ lymphocytes can control HIV infection in vitro by suppressing virus replication
86. Macrophage-tropic HIV and SIV envelope proteins induce a signal through the CCR5 chemokine receptor
87. Intracerebral cytokine messenger RNA expression in acquired immune deficiency syndrome dementia
88. Chemokine receptor expression on resident and inflammatory cells in the brain of macaques with simian immunodeficiency virus encephalitis
89. Distribution of brain HIV load in AIDS [see comments]
90. Interferon-stimulated response element and NF kappa B sites cooperate to regulate double-stranded RNA-induced transcription of the IP-10 gene
91. Intracellular CXCR4 signaling, neuronal apoptosis and neuropathogenic mechanisms of HIV-1-associated dementia