Plasma and brain pharmacokinetics of amitriptyline and its demethylated and hydroxylated metabolites after one and six half-life repeated administrations to rats

General Pharmacology

Volumn 27, Issue 2, 1996, Pages 215-219

  Coudore, F ^a   Besson, A ^a   Eschalier, A ^a   Lavarenne, J ^a   Fialip, J ^a  

^a UNIVERSITÉ CLERMONT AUVERGNE   (France)

Author keywords

acute and repeated administration; amitriptyline; rat demethylated and hydroxylated metabolites

Indexed keywords

10 HYDROXYAMITRIPTYLINE; 10 HYDROXYNORTRIPTYLINE; AMITRIPTYLINE; DINORAMITRIPTYLINE; DRUG METABOLITE; NORTRIPTYLINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOTRANSFORMATION; CONTROLLED STUDY; DEMETHYLATION; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG ELIMINATION; DRUG HALF LIFE; DRUG HYDROXYLATION; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0029988607     PISSN: 03063623     EISSN: None     Source Type: Journal    
DOI: 10.1016/0306-3623(95)02008-X     Document Type: Article

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