Involvement of two basic residues (Lys-17 and Arg-39) of mouse lung carbonyl reductase in NADP(H)-binding and fatty acid activation: Site-directed mutagenesis and kinetic analyses

Journal of Biochemistry

Volumn 120, Issue 2, 1996, Pages 257-263

  Nakanishi, Masayuki ^a   Kakumoto, Mikio ^b   Matsuura, Kazuya ^b   Deyashiki, Yoshihiro ^b   Tanaka, Nobutada ^c   Nonaka, Takamasa ^c   Mitsui, Yukio ^c   Kara, Akira ^b  

^a GIFU UNIVERSITY   (Japan)

^b GIFU PHARMACEUTICAL UNIVERSITY   (Japan)

^c NAGAOKA UNIVERSITY OF TECHNOLOGY   (Japan)

Author keywords

Carbonyl reductase; Fatty acid activation; NADP(H) specificity; Short chain dehydrogenase reductase family; Site directed mutagenesis

Indexed keywords

ALANINE; ARGININE; CARBONYL REDUCTASE; HISTIDINE; LYSINE; NICOTINAMIDE ADENINE DINUCLEOTIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMAL TISSUE; ARTICLE; ENZYME KINETICS; GENETIC CONSERVATION; MOUSE; NONHUMAN; SITE DIRECTED MUTAGENESIS; THERMODYNAMICS;

ANIMALIA;

EID: 0029683826     PISSN: 0021924X     EISSN: None     Source Type: Journal    
DOI: 10.1093/oxfordjournals.jbchem.a021407     Document Type: Article

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