Gliadin nanoparticles as carriers for the oral administration of lipophilic drugs. Relationships between bioadhesion and pharmacokinetics

Pharmaceutical Research

Volumn 18, Issue 11, 2001, Pages 1521-1527

  Arangoa, M A ^a   Campanero, M A ^b   Renedo, M J ^a   Ponchel, G ^c   Irache, J M ^a  

^a UNIVERSITY OF NAVARRA   (Spain)

^b UNIVERSITY CLINIC OF NAVARRA   (Spain)

^c UNIV PARIS SUD   (France)

Author keywords

Absorption; Bioadhesion; Bioavailability; Deconvolution; Gliadin; Nanoparticles

Indexed keywords

ALCOHOL; CARBAZOLE DERIVATIVE; DRUG CARRIER; GLIADIN; GLUTARALDEHYDE; NANOPARTICLE; PROPYLENE GLYCOL; WATER;

ADHESION; ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG ELIMINATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIPOPHILICITY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; STOMACH MUCOSA; SUSTAINED RELEASE FORMULATION; ZETA POTENTIAL;

EID: 0034747890     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1013018111829     Document Type: Article

References (26)

1. Bioadhesive polymers as platforms for oral controlled drug delivery III: Oral delivery of chlorothiazide using a bioadhesive polymer
2. Peroral administration of nanoparticles
3. Mucoadhesion of polystyrene nanoparticles having surface hydrophilic polymeric chains in the gastrointestinal tract
4. Mucoadhesion of latexes. II. Adsorption isotherms and desorption studies
5. Bioadhesives/mucoadhesives in drug delivery to the gastrointestinal tract
6. Bioadhesion technologies for the delivery of peptide and protein drugs to the gastrointestinal tract
7. Oral peptide delivery using nanoparticles composed of novel graft copolymers having hydrophobic backbone and hydrophilic branches
8. Disposition kinetics and oral bioavailability of vincamin-loaded polyalkycyanoacrylate nanoparticles
9. Bioadhesive microspheres: III. An in vivo transit and bioavailability study of drug-loaded alginate and poly(fumaric-co-sebacic anhydride) microspheres
10. Biologically erodable microspheres as potential oral drug delivery systems
11. In vitro and in vivo evaluation of mucoadhesive microspheres prepared for the gastrointestinal tract using polyglycerol esters of fatty acids and a poly(acrylic acid) derivative
12. Evaluation of oral mucoadhesive microspheres in man on the basis of the pharmacokinetics of furosemide and riboflavin, compounds with limited gastrointestinal absorption sites
13. Bioadhesive potential of gliadin nanoparticulate systems
14. Prediction of carbazole solubility and its dependence upon the solvent nature
15. Evaluation and characterisation of gliadin nanoparticles and isolates by reversed-phase HPLC
16. Electrophoretic separation and characterisation of gliadin fractions from isolates and nanoparticulate drug delivery systems
17. Gliadin nanoparticles for the controlled release of all-trans-retinoic acid
18. A new criterion for selection of pharmacokinetic multiexponential equations
19. Calculation of partial components of biovailability in slow release formulations using model-independent methods
20. Pharmacokinetics of oral zidovudine entrapped in biodegradable nanospheres in rabbits
21. Pharmacokinetics of microparticulate systems
22. A computer program (DCN) for numerical convolution and deconvolution of pharmacokinetic functions
23. Bioavailability of hydroxychloroquine tablets assessed with deconvolution techniques
24. Deconvolution analysis for absorption and metabolism of aspirin in microcapsules