P-glycoprotein at the blood-brain barrier and analysis of drug transport with positron-emission tomography

Journal of Clinical Pharmacology

Volumn 41, Issue 7 SUPPL., 2001, Pages

  Hendrikse, N H ^a   Bart, J ^a   De Vries, E G E ^a   Groen, H J M ^a   Van Der Graaf, W T A ^a   Vaalburg, W ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOPROTEIN P; DRUG;

BLOOD BRAIN BARRIER; BRAIN PROTECTION; CELL MEMBRANE; CONFERENCE PAPER; DEFENSE MECHANISM; DRUG TRANSPORT; POSITRON EMISSION TOMOGRAPHY; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN TRANSPORT; ACTIVE TRANSPORT; ANIMAL; BRAIN; BRAIN LEVEL; COMPUTER ASSISTED EMISSION TOMOGRAPHY; HUMAN; METABOLISM; PHYSIOLOGY; REVIEW; SCINTISCANNING;

ANIMALS; BIOLOGICAL TRANSPORT, ACTIVE; BLOOD-BRAIN BARRIER; BRAIN; BRAIN CHEMISTRY; HUMANS; P-GLYCOPROTEIN; PHARMACEUTICAL PREPARATIONS; TOMOGRAPHY, EMISSION-COMPUTED;

EID: 0034743494     PISSN: 00912700     EISSN: None     Source Type: Journal    
DOI: 10.1177/009127001773744152     Document Type: Conference Paper

References (48)

1. Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites
2. Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues
3. In vivo detection of multidrug-resistant (MDR1) pheno-type by technetium-99m sestamibi scan in untreated breast cancer patients
4. P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs
5. Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs
6. Absence of the mdr1a P-glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A
7. The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors
8. Saquinavir, an HIV protease inhibitor, is transported by P-glycoprotein
9. HIV-1 protease inhibitors are substrates for the MDR1 multidrug transporter
10. Concentration of vinblastine in human intracerebral tumor and other tissues
11. Human central nervous system and plasma pharmacology of mitoxantrone
12. Adjuvant treatment with cyclosporin A increases the toxicity of chemotherapy for remission induction in acute non-lymphocytic leukemia
13. Modulation of the multidrug resistance P-glycoprotein: Detection with technetium-99m-sestamibi in vivo
14. Full blockade of intestinal P-glycoprotein and extensive inhibition of blood-brain barrier P-glycoprotein by oral treatment of mice with PSC833
15. Altered pharmacokinetics of vinblastine in Mdr1a P-glycoprotein-deficient Mice
16. In vivo uptake of carbon-14-colchicine for identification of tumor multidrug resistance
17. Control of brain endothelial permeability
18. Morphometric analysis of CNS microvascular endothelium
19. Electrical resistance across the blood-brain barrier in anaesthetized rats: A developmental study
20. Relationship of octanol/water partition coefficient and molecular weight to rat brain capillary permeability
21. Octanol-water partition: Searching for predictive models
22. Role of blood-brain barrier P-glycoprotein in limiting brain accumulation and sedative side-effects of asimadoline, a peripherally acting analgaesic drug
23. The functional role of P-glycoprotein in the blood-brain barrier
24. The role of P-glycoprotein in blood-brain barrier transport of morphine: Transcortical microdialysis studies in mdr1a (-/-) and mdr1a (+/+) mice
25. Pharmacologic interactions between the resistance-modifying cyclosporine SDZ PSC 833 and etoposide (VP 16-213) enhance in vivo cytostatic activity and toxicity
26. SDZ 280-446, a novel semi-synthetic cyclopeptolide: In vitro and in vivo circumvention of the P-glycoprotein-mediated tumour cell multidrug resistance
27. Modulation of multidrug resistance (MDR) in hematological malignancies
28. Results of a phase III, double-blind, placebo-controlled trial of megestrol acetate modulation of P-glycoprotein-mediated drug resistance in the first-line management of small-cell lung carcinoma
29. Phase III study of PSC-833 modulation of multidrug resistance (MDR) in previously untreated acute myeloid leukemia (AML) patients 60 years (CALGB 9720)
30. Clinical trials of modulation of multidrug resistance: Pharmacokinetic and pharmacodynamic considerations
31. Cyclosporine
32. Functional imaging of multidrug-resistant P-glycoprotein with an organotechnetium complex
33. Expression of recombinant human multidrug resistance P-glycoprotein in insect cells confers decreased accumulation of technetium-99m-sestamibi
34. 99mTc-sestamibi as an agent for imaging P-glycoprotein-mediated multi- drug resistance: In vitro and in vivo studies in a rat breast tumour cell line and its doxorubicin-resistant variant
35. 99mTc-Sestamibi is a substrate for P-glycoprotein and the multidrug resistance-associated protein
36. Complete in vivo reversal of P-glycoprotein pump function in the blood-brain barrier visualized with positron emission tomography
37. Quinidine as a resistance modulator of epirubicin in advanced breast cancer: Mature results of a placebo-controlled randomized trial
38. A randomised clinical study of verapamil in addition to combination chemotherapy in small cell lung cancer
39. A phase III randomized study of oral verapamil as a chemosensitizer to reverse drug resistance in patients with refractory myeloma
40. A new in vivo method to study P-glycoprotein transport in tumors and the blood-brain barrier
41. 11C]-verapamil kinetics in human tissues
42. Increased neurotoxicity with VAD-cyclosporin in multiple myeloma
43. Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines
44. Expression of human MRP6, a homologue of the multidrug resistance protein gene MRP1, in tissues and cancer cells
45. Expression of multidrug resistance-associated protein (MRP) in brain microvessel endothelial cells
46. Characterization of efflux transport of organic anions in a mouse brain capillary endothelial cell line
47. Multidrug resistance-related transport proteins in isolated human brain microvessels and in cells cultured from these isolates
48. Tissue distribution of the multidrug resistance protein