Vα gene replacement in a TCRα knock-in mouse

European Journal of Immunology

Volumn 31, Issue 10, 2001, Pages 2919-2925

  Golub, Rachel ^a,b   Huang, Ching Yu ^c   Kanagawa, Osami ^c   Wu, Gillian E ^a,d  

^a UNIVERSITY OF TORONTO   (Canada)

^b INSTITUT PASTEUR   (France)

^c WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d PRINCESS MARGARET HOSPITAL   (Canada)

Author keywords

Generation of diversity; Knockout; Repertoire development; T cell receptor; Transgenic; V gene replacement

Indexed keywords

T LYMPHOCYTE RECEPTOR; CD3 ANTIGEN; CD4 ANTIGEN;

ANIMAL CELL; ARTICLE; B LYMPHOCYTE; CONTROLLED STUDY; GENE LOCUS; GENE REARRANGEMENT; GENETIC CONSERVATION; IMMUNE SYSTEM; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; SPLEEN; T LYMPHOCYTE; ANIMAL; GENETICS; IMMUNOGLOBULIN VARIABLE REGION; METABOLISM; MOUSE MUTANT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; T LYMPHOCYTE RECEPTOR GENE;

ANIMALS; ANTIGENS, CD3; ANTIGENS, CD4; GENE REARRANGEMENT; GENES, T-CELL RECEPTOR ALPHA; GENES, T-CELL RECEPTOR BETA; IMMUNOGLOBULIN VARIABLE REGION; MICE; MICE, KNOCKOUT; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; T-LYMPHOCYTES;

EID: 0034740640     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(2001010)31:10<2919::AID-IMMU2919>3.0.CO;2-N     Document Type: Article

References (42)

1. Size estimate of the alpha beta TCR repertoire of naive mouse splenocytes
2. The mechanisms of V(D)J joining: Lessons from molecular, immunological and comparative analyses
3. Positive selection of thymocytes
4. Negative selection of lymphocytes
5. T-cell antigen receptor genes and T-cell recognition
6. Critical relationship between TCR signaling potential and TCR affinity during thymocyte selection
7. The developmental biology of T lymphocytes
8. Development and selection of T cells: Facts and puzzles
9. The quantity of TCR signal determines positive selection and lineage commitment of T cells
10. + T cell responses in vivo
11. A T cell clone expresses two T cell receptor alpha genes but uses one alpha beta heterodimer for allorecognition and self MHC-restricted antigen recognition
12. Exclusion and inclusion of alpha and beta T cell receptor alleles
13. Frequency and characterization of penotypic Ig heavy chain allelically included IgM-expressing B cells in mice
14. A mouse with a monoclonal primary immunoglobulin repertoire not further diversified by V-gene replacement
15. VHDJH formation and DJH replacement during pre-B differentiation: Non-random usage of gene segments
16. Recombination between an expressed immunoglobulin heavy-chain gene and a germline variable gene segment in a Ly 1 + B-cell lymphoma
17. Immunoglobulin heavy chain gene replacement: A mechanism of receptor editing
18. V(D)J recombination in mature B cells: A mechanism for altering antibody responses
19. Editing disease-associated autoantibodies
20. V(H) gene replacement occurs in the spleen and bone marrow of non-autoimmune quasi-monoclonal mice
21. VH to VHDJH rearrangement is mediated by the internal VH heptamer
22. Molecular mechanisms involved in receptor editing at the Ig heavy chain locus
23. Sequences of proteins of immunological interest
24. Rapid deletion of rearranged T cell antigen receptor (TCR) Valpha-Jalpha segment by secondary rearrangement in the thymus: Role of continuous rearrangement of TCR alpha chain gene and positive selection in the T formation. P.N.A.S
25. Ordered and coordinated rearrangement of the TCR alpha locus: Role of secondary rearrangement in thymic selection
26. Evolution of antigen-specific T cell receptors in vivo: Preimmune and antigen-driven selection of preferred complementarity-determining region 3 (CDR3) motifs
27. Specific antibody production by V(H)-gene replacement
28. T cell receptor gene diversity and selection
29. Thymocyte expression of RAG-1 and RAG-2: Termination by T cell receptor cross-linking
30. Engagement of the T-cell receptor during positive selection in the thymus down-regulates RAG-1 expression
31. Two waves of recombinase gene expression in developing thymocytes
32. Enhancer control of V(D)J recombination at the TCRbeta locus: Differential effects on DNA cleavage and joining
33. Developmental regulation of V(D)J recombination at the TCR alpha/delta locus
34. Developmental regulation of TCR delta locus accessibility and expression by the TCR delta enhancer
35. RAG re-expression and DNA recombination at T cell receptor loci in peripheral CD4+ T cells
36. low mature T lymphocytes
37. The joining of germ-line V alpha to J alpha genes replaces the preexisting V alpha-J alpha complexes in a T cell receptor alpha, beta positive T cell line
38. Multiple rearrangements in T cell receptor alpha chain genes maximize the production of useful thymocytes
39. Crpytic signals and the fidelity of V(D)J joining
40. DNA sequence and structure requirements for cleavage of V(D)J recombination signal sequences
41. Codon usage tabulated from the international DNA sequence databases
42. Gapped BLAST and PSI-BLAST: A new generation of protein database search programs