Endotoxin suppresses the oltipraz-mediated induction of major hepatic glutathione transferases and cytochromes P450 in the rat

Hepatology

Volumn 28, Issue 6, 1998, Pages 1655-1662

  Mahéo, Karine ^a   Morel, Fabrice ^a   Antras Ferry, Jocelyne ^a   Langouët, Sophie ^a   Desmots, Fabienne ^a   Corcos, Laurent ^a   Guillouzo, André ^a  

^a UNIVERSITÉ DE RENNES 1   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; CYTOCHROME P450; ESCHERICHIA COLI ENDOTOXIN; GLUTATHIONE TRANSFERASE; OLTIPRAZ;

ACUTE PHASE RESPONSE; ANIMAL TISSUE; ARTICLE; DETOXIFICATION; DRUG MECHANISM; ENDOTOXEMIA; ENZYME ACTIVITY; ENZYME INDUCTION; GENE OVEREXPRESSION; GENETIC TRANSCRIPTION; IMMUNOBLOTTING; INFLAMMATION; LIVER; LIVER TOXICITY; MALE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RAT;

EID: 0031768584     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.510280627     Document Type: Article

References (19)

1. Hayes JD, Pulford DJ. The glutathione 5-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance. Crit Rev Biochem Mol Biol 1995;30:445-600.
2. Nebert DW, Nelson DR, Adesnik M, Coon MJ, Estabrook RW, Gonzalez FJ, Guengerich FF, et al. The P450 superfamily: updated listing of all genes and recommended nomenclature for the chromosomal loci. DNA 1989;8:1-13.
3. Andus T, Bauer J, Gerok W. Effects of cytokines on the liver. HEPATOLOGY 1991;13:364-375.
4. Renton KW. Factors affecting drug biotransformation. Clin Biochem 1986;19:72-75.
5. Endo Y, Tsuriya S, Fujihira E. Hepatic drug-metabolizing enzyme activities and anti-inflammatory potency of hydrocortisone in rats with granulomatous inflammation. Res Commun Chem Pathol Pharmacol 1981;33:195-206.
6. Gorodischer F, Krasner J, McDevitt JJ, Nolan JP, Yaffe SJ. Hepatic microsomal drug metabolism after administration of endotoxin in rats. Biochem Pharmacol 1976;25:351-353.
7. Ghezzi P, Saccardo B, Villa P, Rossi V, Bianchi M, Dinarello CA. Role of interleukin-1 in the depression of liver drug metabolism by endotoxin. Infect Immun 1986;54:837-840.
8. Baumann H, Gauldie J. The acute phase response. Immunol Today 1994;15:74-80.
9. Morgan ET, Thomas KB, Swanson R, Vales T, Hwang J, Wright K. Selective suppression of cytochrome P-450 gene expression by interleukins 1 and 6 in rat liver. Biochim Biophys Acta 1994;1219:475-483.
10. Renton KW, Knickle LC. Regulation of hepatic cytochrome P-450 during infectious disease. Can J Physiol Pharmacol 1990;68:777-781.
11. Abdel-Razzak Z, Loyer P, Fautrel A, Gautier JC, Corcos L, Turlin B, Beaune P, et al. Cytokines down-regulate expression of major cytochrome P-450 enzymes in adult human hepatocytes in primary culture. Mol Pharmacol 1993;44:707-715.
12. Abdel-Razzak Z, Corcos L, Fautrel A, Guillouzo A. Interleukin-1 beta antagonizes phenobarbital induction of several major cytochromes P450 in adult rat hepatocytes in primary culture. FEBS Lett 1995;366:159-164.
13. Maheo K, Antras-Ferry J, Morel F, Langouet S, Guillouzo A. Modulation of glutathione S-transferase subunits A2, M1, and P1 expression by interleukin-1beta in rat hepatocytes in primary culture. J Biol Chem 1997;272:16125-16132.
14. Zhang Y, Kensler TW, Cho CG, Posner GH, Talalay P. Anticarcinogenic activities of sulforaphane and structurally related synthetic norbomyl isothiocyanates. Proc Natl Acad Sci U S A 1994;91:3147-3150.
15. Kensler TW, Egner PA, Dolan PM, Groopman JD, Roebuck BD. Mechanism of protection against aflatoxin tumorigenicity in rats fed 5-(2-pyrazinyl)-4-methyl-1,2-dithiol-3-thione (oltipraz) and related 1,2-dithiol-3-thiones and 1,2-dithiol-3-ones. Cancer Res 1987;47:4271-4277.
16. Raney KD, Meyer DJ, Ketterer B, Harris TM, Guengerich FP. Glutathione conjugation of aflatoxin B1 exo- and endo-epoxides by rat and human glutathione S-transferases. Chem Res Toxicol 1992;5:470-478.
17. Langouet S, Coles B, Morel F, Becquemont L, Beaune P, Guengerich FP, Ketterer B, et al. Inhibition of CYP1A2 and CYP3A4 by oltipraz results in reduction of aflatoxin B1 metabolism in human hepatocytes in primary culture. Cancer Res 1995;55:5574-5579.
18. Langouet S, Maheo K, Berthou F, Morel F, Lagadic-Gossman D, Glaise D, Coles B, et al. Effects of administration of the chemoprotective agent oltipraz on CYP1A and CYP2B in rat liver and rat hepatocytes in culture. Carcinogenesis 1997;18:1343-1349.
19. Qian GS, Ross RK, Yu MC, Yuan JM, Gao YT, Henderson BE, Wogan GN, et al. A follow-up study of urinary markers of aflatoxin exposure and liver cancer risk in Shanghai, People's Republic of China. Cancer Epidemiol Biomarkers Prev 1994;3:3-10.