Model for the cofactor formation reaction of E. Coli ribonucleotide reductase. From a Diiron(II) precursor to an Fe(III)Fe(IV) species via a peroxo intermediate

Inorganic Chemistry

Volumn 39, Issue 11, 2000, Pages 2254-2255

  MacMurdo, Vicki L ^a   Zheng, Hui ^a   Que Jr , Lawrence ^a  

^a University of Minnesota ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RIBONUCLEOTIDE REDUCTASE; IRON; ORGANOMETALLIC COMPOUND;

ANAEROBIC METABOLISM; ARTICLE; CRYSTAL STRUCTURE; CRYSTALLIZATION; ELECTRON SPIN RESONANCE; ENZYME MECHANISM; ESCHERICHIA COLI; OXIDATION; OXIDATION REDUCTION REACTION; X RAY CRYSTALLOGRAPHY; BINDING SITE; CATALYSIS; CHEMICAL MODEL; CHEMISTRY; CONFORMATION; ENZYMOLOGY; KINETICS; METABOLISM; ULTRAVIOLET SPECTROPHOTOMETRY;

BINDING SITES; CATALYSIS; ELECTRON SPIN RESONANCE SPECTROSCOPY; ESCHERICHIA COLI; IRON; KINETICS; MODELS, CHEMICAL; MOLECULAR CONFORMATION; ORGANOMETALLIC COMPOUNDS; OXIDATION-REDUCTION; RIBONUCLEOTIDE REDUCTASES; SPECTROPHOTOMETRY, ULTRAVIOLET;

EID: 0034729040     PISSN: 00201669     EISSN: None     Source Type: Journal    
DOI: 10.1021/ic991482m     Document Type: Article

References (34)

1. (a) Stubbe, J.; Riggs-Gelasco, P. Trends Biochem. Sci. 1998, 23, 438-443.
2. (b) Wallar, B. J.; Lipscomb, J. D. Chem. Rev. 1996, 96, 2625-2658.
3. (c) Kurtz, D. M., Jr. J. Biol. Inorg. Chem. 1997, 2, 159-167.
4. (a) Bollinger, J. M.; Edmondson, D. E.; Huynh, B. H.; Filley, J.; Norton, J.; Stubbe, J. Science (Washington, D.C.) 1991, 253, 292-298.
5. (b) Bollinger, J. M., Jr.; Krebs, C.; Vicol, A.; Chen, S.; Ley, B. A.; Edmondson, D. E.; Huynh, B. H. J. Am. Chem. Soc. 1998, 120, 1094-1095.
6. (c) Sturgeon, B. E.; Burdi, D.; Chen, S.; Huynh, B. H.; Edmondson, D. E.; Stubbe, J.; Hoffman, B. M. J. Am. Chem. Soc. 1996, 118, 7551-7557.
7. (d) Riggs-Gelasco, P. J.; Shu, L.; Chen, S.; Burdi, D.; Huynh, B. H.; Que, L., Jr.; Stubbe, J. J. Am. Chem. Soc. 1998, 120, 849-860.
8. (a) Dong, Y.; Ménage, S.; Brennan, B. A.; Elgren, T. E.; Jang, H. G.; Pearce, L. L.; Que, L., Jr. J. Am. Chem. Soc. 1993, 115, 1851-1859.
9. (b) Kitajima, N.; Tamura, N.; Amagai, H.; Fukui, H.; Moro-oka, Y.; Mizutani, Y.; Kitagawa, T.; Mathur, R.; Heerwegh, K.; Reed, C. A.; Randall, C. R.; Que, L., Jr.; Tatsumi, K. J. Am. Chem. Soc. 1994, 116, 9071-9085.
10. (c) Hayashi, Y.; Kayatani, T.; Sugimoto, H.; Suzuki, M.; Inomata, K.; Uehara, A.; Mizutani, Y.; Kitagawa, T.; Maeda, Y. J. Am. Chem. Soc. 1995, 117, 11220-11229.
11. (d) Hagadorn, J. R.; Que, L., Jr.; Tolman, W. B. J. Am. Chem. Soc. 1998, 120, 13531-13532.
12. (a) Dong, Y.; Fujii, H.; Hendrich, M. P.; Leising, R. A.; Pan, G.; Randall, C. R.; Wilkinson, E. C.; Zang, Y.; Que, L., Jr.; Fox, B. G.; Kauffmann, K.; Münck, E. J. Am. Chem. Soc. 1995, 117, 2778-2792.
13. (b) Hsu, H.-F.; Dong, Y.; Shu, L.; Young, V. G., Jr.; Que, L., Jr. J. Am. Chem. Soc. 1999, 121, 5230-5237.
14. (c) Dong, Y.; Zang, Y.; Kauffmann, K.; Shu, L.; Wilkinson, E. C.; Münck, E.; Que, L., Jr. J. Am. Chem. Soc. 1997, 119, 12683-12684.
15. (d) Dong, Y.; Que, L., Jr.; Kauffmann, K.; Münck, E. J. Am. Chem. Soc. 1995, 117, 11377-11378.
16. (a) Lee, D.; DuBois, J.; Petasis, D.; Hendrich, M. P.; Krebs, C.; Huynh, B. H.; Lippard, S. J. J. Am. Chem. Soc. 1999, 121, 9893-9894.
17. (b) Lee, D.; Lippard, S. J. J. Am. Chem. Soc. 1998, 120, 12153-12154.
18. Another diiron(II) model system has recently been reported that also reacts with dioxygen to form an Fe(III)Fe(IV) species. However, no peroxo intermediate has been observed (ref 5a).
19. 3.5-iPr2, hydrotris(3,5-diisopropylpyrazol-1-yl)borate; 6-Me-TPA, N-(6-methyl-2-pyridylmethyl)-N,N-bis(2-pyridylmethyl)amine.
20. w = 0.1027.
21. (a) Hikichi, S.; Ogihara, T.; Fujisawa, K.; Kitajima, N.; Akita, M.; Morooka, Y. Inorg. Chem. 1997, 36, 4539-4547.
22. (b) Kitajima, N.; Tamura, N.; Tanaka, M.; Moro-oka, Y. Inorg. Chem. 1992, 31, 3342-3343.
23. (a) Kurtz, D. M. Chem. Rev. 1990, 90, 585-606.
24. (b) Zheng, H.; Zang, Y.; Dong, Y.; Young, V. G., Jr.; Que, L., Jr. J. Am. Chem. Soc. 1999, 121, 2226-2235.
25. Reynolds, R. A., III: Yu, W. O.; Dunham, W. R.; Coucouvanis, D. Inorg. Chem. 1996, 35, 2721-2722.
26. (a) Hendrich, M. P.; Münck, E.; Fox, B. G.; Lipscomb, J. D. J. Am. Chem. Soc. 1990, 112, 5861-5865.
27. (b) Hendrich, M. P.; Pearce, L. L.; Que, L., Jr.; Chasten, N. D.; Day, E. P. J. Am. Chem. Soc. 1991, 113, 3039-3044.
28. (c) Jang, H. G.; Hendrich, M. P.; Que, L., Jr. Inorg. Chem. 1993, 32, 911-918.
29. -1 was obscured by unassigned contaminating features (ref 4c).
30. (a) Moënne-Loccoz, P.; Baldwin, J.; Ley, B. A.; Loehr, T. M.; Bollinger, J. M., Jr. Biochemistry 1998, 37, 14659-14663.
31. (b) Broadwater, J. A.; Ai, J.; Loebr, T. M.; Sanders-Loehr, J.; Fox, B. G. Biochemistry 1998, 37, 14664-14671.
32. (c) Moënne-Loccoz, P.; Krebs, C.; Herlihy, K.; Edmondson, D. E.; Theil, E. C.; Huynh, B. H.; Loehr, T. M. Biochemistry 1999, 38, 5290-5295.
33. 18O shifts observed suggest that other assignments should be considered (ref 3c).
34. Ravi, N.; Bollinger, J. M., Jr.; Huynh, B. H.; Edmondson, D. E.; Stubbe, J. J. Am. Chem. Soc. 1994, 116, 8007-8014.