Improving the refolding yield of interleukin-4 through the optimization of local interactions

Journal of Biotechnology

Volumn 84, Issue 3, 2000, Pages 217-230

  Domingues, Helena ^a   Peters, Jörg ^d   Schneider, Karl Hans ^d   Apeler, Hans ^d   Sebald, Walter ^b   Oschkinat, Hartmut ^c   Serrano, Luis ^a  

^a EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^b UNIVERSITY OF WÜRZBURG   (Germany)

^c LEIBNIZ INSTITUT FÜR MOLEKULARE PHARMAKOLOGIE   (Germany)

^d BAYER AG   (Germany)

Author keywords

IL 4; Mutagenesis; Refolding; Stability; Yield; Helix

Indexed keywords

INTERLEUKIN 4; MUTANT PROTEIN; SERINE; SOLVENT;

ALPHA HELIX; AMINO ACID SEQUENCE; ARTICLE; HYDROPHOBICITY; IN VITRO STUDY; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN INTERACTION; PROTEIN STABILITY; TEMPERATURE;

DRUG PRODUCTS; HYDROPHOBICITY; MUTAGENESIS; SOLVENTS;

INTERLEUKIN; PROTEIN REFOLDING;

PROTEINS;

EID: 0034727794     PISSN: 01681656     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-1656(00)00327-8     Document Type: Article

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