Endotoxin and cytokines induce direct cardiodepressive effects in mammalian cardiomyocytes via induction of nitric oxide synthase

Journal of Molecular and Cellular Cardiology

Volumn 28, Issue 8, 1996, Pages 1631-1639

  Stein, Birgitt ^a   Frank, Petra ^a   Schmitz, Wilhelm ^b   Scholz, Hasso ^a   Thoenes, Martin ^a  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^b UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

Cardiomyocytes; Contractility, cGMP content, endotoxin, cytokines; Heart; Inducible nitric oxide synthase

Indexed keywords

ARGININE DERIVATIVE; BACTERIUM LIPOPOLYSACCHARIDE; CYCLIC GMP; CYTOKINE; DEXAMETHASONE; ENDOTOXIN; INTERLEUKIN 1BETA; NITRIC OXIDE SYNTHASE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME INDUCTION; ENZYME SYNTHESIS; GUINEA PIG; HEART MUSCLE CELL; HEART MUSCLE CONTRACTILITY; INOTROPISM; MAMMAL; MYOCARDITIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEPTIC SHOCK; TIME; VASCULAR SMOOTH MUSCLE;

ANIMALIA; BACTERIA (MICROORGANISMS); CAVIA PORCELLUS; MAMMALIA; SUS SCROFA;

EID: 0030217871     PISSN: 00222828     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmcc.1996.0153     Document Type: Article

References (36)

1. BALLIGAND JL, UNGUREANU D, KELLY RA, KOBZIK L, PIMENTAL D, MICHEL T, SMITH TW, 1993. Abnormal contractile function due to induction of nitric oxide synthesis in rat cardiac myocytes follows exposure to activated macrophage conditioned medium. J Clin Invest 91: 2314-2319.
2. BALLINGAND JL, UNGUREANU-LONGROIS D, SIMMONS WW, PIMENTAL D, MALINSKI TA, KAPTURCZAK M, TAHA Z, LOWENSTEIN CJ, DAVIDOFF AJ, KELLY RA, SMITH TW, MICHEL T, 1994. Cytokine-inducible nitric oxide synthase (iNOS) expression in cardiac myocytes. J Biol Chem 269: 72780-27588.
3. BEUTLER B, CERAMI A, 1989, The biology of cachetin/ TNF. - A primary mediator of the host response. Annu Rev Immunol 7: 625-655.
4. BRADFORD MM, 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248-254.
5. BRADY AJ, POOLE-WILSON PA, HARDING SE, WARREN JB, 1992. Nitric oxide production within cardiac myocytes reduces their contractility in endotoxemia. Am J Physiol 263: H1963-H1966.
6. BRUTSAERT DL, 1989. The endocardium. Annu Rev Physiol 51: 263-273.
7. BUSSE R, MÜLSCH A, 1990. Induction of niric oxide synthase by cytokines in vascular smooth muscle cells. FEBS Lett 257: 87-90.
8. DE BELDER AJ, RADOMSKI MW, WHY HJF, RICHARDSON PJ, BUCKNALL CA, SALALS E, MARTIN JF, MONCADA S, 1993. Nitric oxide synthase activities in human myocardium. Lancet 341: 84-85.
9. DE GROOTE MA, MARTIN MA, DENSEN P, PAELLER MA, WENZEL RP, 1989. Plasma tumor necrosis factor levels in patients with presumed sepsia. JAMA 262: 249-251.
10. FINKEL MS, ODDIS CV, JACOB TD, WATKINS SC, HATTLER BG, SIMMONS RL. 1992. Negative inotropic effects of cytokines on the heart mediated by nitric oxide. Science 257: 387-389.
11. FÖRSTERMANN U, SCHMIDT HHHW, POLLOCK JS, SHENG H, MITCHELL JA, WARNER TD, NAKANE M, MURAD F, 1991. Isoforms of nitric oxide synthase. Characterization and purification from different cell types. Biochem Pharmacol 42 1849-1857.
12. FRENCH JF, VELAYO NL, DRAGE RC, 1992. Interleukin-1 β increases synthesis of cyclic GMP in cardiac myocytes by inducing the formation of nitric oxide. In: Moncada S, Marletta MA, Hibbs JB, Higgs EA, eds. The Biology of Nitric Oxide, 1, Physiological and Clinical Aspects. London, England: Portland Press, 218-222.
13. GRUETTER CA, GRUETTER DY, LYON JE, KADOWITZ PJ, IGNARRO LJ, 1981. Relationship between cyclic guanosine 3′:5′-monophosphate formation and relaxation of coronary arterial smooth muscle by glyceryl trinitrate, nitroprusside, nitrite and nitric oxide: Effects of methyline blue and methemoglobin. J Pharmacol Exp Ther 219: 181-186.
14. HASSALL CJS, SAFFREY MJ, BELAI A, HOYLE CHV, MOULES EW, MOSS J, SCHMIDT HHHW, MURAD F, FÖRSTERMANN U, BURNSTOCK G, 1992. Nitric oxide synthase immunoreactivity and NADPH-diaphorase activity in a subpopulation of intrinsic neurones of the guinea-pig heart. Neurosci Lett 143: 65-68.
15. i and cell contraction in cultured chick ventricular myocytes. Circ Res 74:285-295.
16. KLIMASCHEWSKI L, KUMMER W, MAYER B, COURAUD JY, PREISSLER U, PHILIPPIN B, KEYM C, 1992. Nitric oxide synthase in cardiac nerve fibers and neurons of rat and guinea pig heart. Circ Res 71: 1533-1537.
17. KNOWLES RG, SALTER M, BROOKS SL, MONCADA S. 1990. Anti-inflammatory glucocorticoids inhibit the induction by endotoxin of nitric oxide synthases in the lung, liver and aorta of the rat. Biochem Biophys Res Commun 172: 1042-1048.
18. MARSH J, LACHANCE D, KIM D, 1985. Mechanisms of β-adrenergic receptor regulation in cultured heart cells: Role of cytoskeleton function and protein synthesis. Circ Res 23: 171-181.
19. ++-current is regulated by cyclic GMP-dependent kinase in mammalian cardiac myocytes. Proc Natl Acad Sci USA 88: 1197-1201.
20. MONCADA S, PALMER RMJ, HIGGS EA. 1991. Nitric oxide: physiology, pathophysiology and pharmacology. Pharmacol Rev 43: 109-142.
21. NATHAN C, XIE Q, 1994. Nitric oxide synthases: roles, tolls, and controls. Cell 78: 915-918.
22. NÜSSLER AK, BILLIAR TD, 1993. Inflammation, immunoregulation and inducible nitric oxide synthase. J Leukocyte Biol 54: 171-178.
23. PARKER JL, ADAMS RH, 1985. Development of myocardial dysfunction in endotoxin shock. Am J Physiol 248: H818-H826.
24. REES DD, CELLEK S, PALMER RMJ, MONCADA S, 1990. Dexamethasone prevents the induction by endotoxin of a nitric oxide synthases and the associated effects on vascular tone. An insight into endotoxin shock. Biochem Biophys Res Commun 173: 541-547.
25. ROOT RK, JACOBS R, 1991. Septicaemia and septic shock. In: Wilson, JD., Brauwald E, and Isselbacher KH., eds. Harrison's Principles of internal Medicine. 12th ed. New York/McGraw-Hill, 502-534.
26. SCHMIDT HHHW, LOHMANN SM, WALTER U, 1993. The nitric oxide and cGMP signal transduction system: regulation and mechanism of action. Biochem Biophys Acta 1178: 153-175.
27. SCHULZ R, SMITH JA, LEWIS JM, MONCADA S, 1991. Nitric oxide synthase in cultured endocardial cells of the pig. Br J Pharmacol 104: 21-24.
28. ++-independent nitric oxide synthase in the myocardium. Br J Pharmacol 105: 575-580.
29. SCHULZ R, TRIGGLE TR, 1994. Role of NO in vascular smooth muscle and cardiac muscle funtion. TIPS 15: 255-259.
30. ++ intact cardiac myocytes. Circ Res 74: 970-978.
31. SHINDO T, IKEDA U, OHAKAWA F, TAKAHASHI M, FUNAYAMA H, NISHINAGA M, KAWAHARA Y, YOKOYAMA M, KASAHARA T, SHIMADA K, 1994. Nitric oxide synthesis in rat cardiac myocytes and fibroblasts. Life Sci 14: 1101-1108.
32. ++-dependent constitutive nitric oxide synthase is not involved in the cyclic GMP-increasing effects of carbachol in ventricular cardiomyocytes. J Pharmacol Exp Ther 266: 919-925.
33. NÜSSLER AK, SCHOLZ H, STEIN B, 1996. Expression of inducible nitric oxide synthase in failing and non-failing human heart. J Mol Cell Cardiol 28: 300-305.
34. WAHLER GM, RUSCH NJ, SPERELAKIS N, 1989. 8-Bromo-cyclic GMP inhibits the calcium current in embryonic chick ventricular myocytes. Can J Physiol Pharmacol 68: 531-534.
35. WEISENSEE D, BEREITER-HAHN J, SCHOEPPE W, LÖW-FRIEDERICH I, 1993. Effects of cytokines on the contractility of cultured cardiac myocytes. Int J Immunopharmac 15: 581-587.
36. WINLAW DS, SMYTHE GA, KEOGH AM, SCHYVENS CG, SPRATT PM, MACDONALD PS, 1994. Increased nitric oxide production in heart failure. Lancet 344: 373-374.