Nitric oxide biosynthesis in an exotoxin-induced septic lung model: Role of cNOS and impact on pulmonary hemodynamics

American Journal of Respiratory and Critical Care Medicine

Volumn 157, Issue 2, 1998, Pages 498-504

  Schütte, Hartwig ^a   Mayer, Konstantin ^a   Gessler, Tobias ^a   Rühl, Marc ^a   Schlaudraff, Jan ^a   Burger, Heiko ^a   Seeger, Werner ^a   Grimminger, Friedrich ^a  

^a JUSTUS LIEBIG UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOETHYLISOTHIOURONIUM; AMINOGUANIDINE; DALTROBAN; EXOTOXIN; HEMOLYSIN; N(G) METHYLARGININE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; THROMBOXANE RECEPTOR BLOCKING AGENT;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOSYNTHESIS; ENZYME INHIBITION; ESCHERICHIA COLI; GAS EXCHANGE; INFLAMMATION; LUNG BLOOD FLOW; LUNG INFECTION; LUNG PERFUSION; NONHUMAN; PRIORITY JOURNAL; RABBIT; VASOCONSTRICTION;

EID: 0031912828     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/ajrccm.157.2.9702094     Document Type: Article

References (35)

1. Moncada, S., R. M. Palmer, and E. A. Higgs. 1991. Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol. Rev. 43:109-142.
2. Zapol, W. M., S. Rimar, N. Gillis, M. Marletta, and C. H. Bosken. 1994. Nitric oxide and the lung. Am. J. Respir. Crit. Care Med. 149:1375-1380.
3. Stamler, J. S., E. Loh, M. A. Roddy, K. E. Currie, and M. A. Creager. 1994. Nitric oxide regulates basal systemic and pulmonary vascular resistance in healthy humans. Circulation 89:2035-2040.
4. Robbins, R. A., D. R. Springall, J. B. Warren, O. J. Kwon, L. D. Buttery, A. J. Wilson, I. M. Adconck, V. Riveros-Moreno, S. Moncada, J. Polak, and P. J. Barnes. 1994. Inducible nitric oxide synthase is increased in murine lung epithelial cells by cytokine stimulation. Biochem. Biophys. Res. Commun. 198:835-843.
5. Nakayama, D. K., D. A. Geller, C. J. Lowenstein, H. D. Chern, P. Davies, B. R. Pitt, R. L. Simmons, and T. R. Billiar. 1992. Cytokines and lipopolysaccharide induce nitric oxide synthase in cultured rat pulmonary artery smooth muscle. Am. J. Respir. Cell Mol. Biol. 7:471-476.
6. Griffiths, M. J., S. Liu, N. P. Curzen, M. Messent, and T. W. Evans. 1995. In vivo treatment with endotoxin induces nitric oxide synthase in rat main pulmonary artery. Am. J. Physiol. 268:L509-L518.
7. Stoclet, J.-C., I. Fleming, G. Gray, G. Julou-Schaeffer, F. Schneider, C. Scott, C. Schott, and J. R. Parratt. 1993. Nitric oxide and endotoxemia. Circulation H7:V77-V80.
8. G-methyl-L-arginine, an inhibitor of nitric oxide synthesis. Biochem. Biophys. Res. Commun. 172:1132-1138.
9. Suttorp, N., M. Fuhrmann, S. Tannert-Otto, F. Grimminger, and S. Bhadki. 1993. Pore-forming bacterial toxins potently induce release of nitric oxide in porcine endothelial cells. J. Exp. Med. 178:337-341.
10. Seeger, W., H. Walter, N. Suttorp, M. Muhly, and S. Bhakdi. 1989. Thromboxane-mediated hypertension and vascular leakage evoked by low doses of Escherichia coli hemolysin in rabbit lungs. J. Clin. Invest. 84:220-227.
11. Spriestersbach, R., F. Grimminger, N. Weissmann, D. Walmrath, and W, Seeger. 1995, On-line measurement of nitric oxide generation in buffer-perfused lungs: release into both the intravascular and alveolar compartment. J. Appl. Physiol. 78:1502-1508.
12. Bhakdi, S., I. Walev, D. Jonas, M. Palmer, U. Weller, N. Suttorp, F. Grimminger, and W. Seeger. 1996. Pathogenesis of sepsis syndrome: possible relevance of pore-forming bacterial toxins. Curr. Top. Microbiol. Immunol. 216:101-118.
13. Seeger, W., D. Walmrath, F. Grimminger, S. Rosseau, H. Schütte, H. J. Krämer, L. Ermert, and L. Kiss. 1994. Adult respiratory distress syndrome: model systems using isolated perfused rabbit lungs. Methods Enzymol. 233:549-584.
14. Grimminger, F., R. Spriestersbach, N. Weissmann, D. Walmrath, and W. Seeger. 1995. Nitric oxide generation and hypoxic vasoconstriction in buffer-perfused rabbit lungs. J. Appl. Physiol. 78:1509-1515.
15. Kharitonov, S. A., O. Lubec, B. Lubec, M. Hjelm, and P. J. Barnes. 1995. L-arginine increases exhaled nitric oxide in normal human subjects. Clin. Sci. 88:135-139.
16. Jeremy, R. W., H. McCarron, and D. Sullivan. 1996. Effects of dietary L-arginine on atherosclerosis and endothelium-dependent vasodilation in the hypercholesterolemic rabbit. Circulation 94:498-506.
17. Pasini, F. L., C. Frigerio, L. De Giorgi, P. Blardi, and T. Di Perri. 1992. L-arginine plasma concentrations in hypercholesterolaemia. Lancet 340: 549.
18. Walmrath, D., H. A. Ghofrani, S. Rosseau, H. Schütte, A. Cramer, W. Kaddus, F. Grimminger, S. Bhakdi, and W. Seeger. 1994. Endotoxin "priming" potentiates lung vascular abnormalities in response to Escherichia coli hemolysin: an example of synergism between endo- and exotoxin. J. Exp. Med. 180:1437-1443.
19. Walmrath, D., J. Pilch, M. Scharmann, F. Grimminger, and W. Seeger. 1994. Severe V̇A/Q̇ mismatch in perfused lungs evoked by sequential challenge with endotoxin and E. coli hemolysin. J. Appl. Physiol. 76: 1020-1030.
20. Lamontagne, D., U. Pohl, and R. Busse. 1992. Mechanical deformation of vessel wall and shear stress determine the basal release of endothelium-derived relaxing factor in the intact rabbit coronary vascular bed. Circ. Res. 70:123-130.
21. Kelm, M., M. Feelisch, A. Deussen, B. E. Strauer, and J. Schrader. 1991. Release of endothelium derived nitric oxide in relation to pressure and flow. Cardiovasc. Res. 25:831-836.
22. Hutcheson, I. R., and T. M. Griffith. 1991. Release of endothelium-derived relaxing factor is modulated both by frequency and amplitude of pulsatile flow. Am. J. Physiol. 261:H257-H262.
23. Hecker, M., A. Mulsch, E. Bassenge, and R. Busse. 1993. Vasoconstriction and increased flow: two principal mechanisms of shear stress-dependent endothelial autacoid release. Am. J. Physiol. 265:H828-H833.
24. Grimminger, F., U. Sibelius, S. Bhakdi, N. Suttorp, and W. Seeger. 1991. Escherichia coli hemolysin is a potent inductor of phosphoinositide hydrolysis and related metabolic responses in human neutrophils. J. Clin. Invest. 88:1531.
25. Newby, A. C., and A. H. Henderson. 1990. Stimulus-secretion coupling in vascular endothelial cells. Annu. Rev. Physiol. 52:661-674.
26. Emori, T., Y. Hirata, K. Kanno, K. Ohta, S. Eguchi, T. Imai, M. Shichiri, and F. Marumo. 1991. Endothelin-3 stimulates production of endothelium-derived nitric oxide via phosphoinositide breakdown. Biochem. Biophys. Res. Commun. 174:228-235.
27. Sterin-Borda, L., A. V. Echague, C. P. Leiros, A. Genaro, and E. Borda, 1995. Endogenous nitric oxide signalling system and the cardiac muscarinic acetylcholine receptor-inotropic response. Br. J. Pharmacol. 115:1525-1531.
28. Loeb, A. L., N. J. Izzo, Jr., R. M. Johnson, J. C. Garrison, and M. J. Peach. 1988. Endothelium-derived relaxing factor release associated with increased endothelial cell inositol trisphosphate and intracellular calcium. Am. J. Cardiol. 62:36G-40G.
29. G-nitro-L-arginine, and aminoguanidine on constitutive and inducible nitric oxide synthase in rat aorta. Biochem. Biophys. Res. Commun. 199:147-154.
30. Griffiths, M. J., M. Messent, N. P. Curzen, and T. W. Evans. 1995. Aminoguanidine selectively decreases cyclic GMP levels produced by inducible nitric oxide synthase. Am. J. Respir. Crit. Care Med. 152:1599-1604.
31. Southan, G. J., C. Szabo, and C. Thiemermann. 1995. Isothioureas: potent inhibitors of nitric oxide synthases with variable isoform selectivity. Br. J. Pharmacol. 114:510-516.
32. Misko, T. P., W. M. Moore, T. P. Kasten, G. A. Nickols, J. A. Corbett, R. G. Tilton, M. L. McDaniel, J. R. Williamson, and M. G. Currie. 1993. Selective inhibition of the inducible nitric oxide synthase by aminoguanidine. Eur. J. Pharmacol. 233:119-125.
33. Sprague, R. S., C. Thiemermann, and J. R. Vane. 1992. Endogenous endothelium-derived relaxing factor opposes hypoxic pulmonary vasoconstriction and supports blood flow to hypoxic alveoli in anesthetized rabbits. Proc. Natl. Acad. Sci. U.S.A. 89:8711-8715.
34. Liu, S. F., D. E. Crawley, P. J. Barnes, and T. W. Evans. 1991. Endothelium-derived relaxing factor inhibits hypoxic pulmonary vasoconstriction in rats. Am. Rev. Respir. Dis. 143:32-37.
35. Petros, A., G. Lamb, A. Leone, S. Moncada, D. Bennett, and P. Vallance. 1994. Effects of a nitric oxide synthase inhibitor in humans with septic shock. Cardiovasc. Res. 28:34-39.