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0342666939
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note
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We have examined the yields of nitrosation of MorH at various low and high initial concentrations of peroxynitrite (0-2 mM) at pH 10.2. Nitrosation of MorH occurs at all concentrations of peroxynitrite, much in the same way as described for pheno!5c and 1, 2-phenylenediamine.15 In these systems, the dependence of nitrosation on peroxynitrite concentration is somewhat curvilinear (for example, see Figure 3A in ref 5c), particularly in reactions performed without added carbonate but supposedly containing some adventitious carbonate."b-'3a
-
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-
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44
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33847561864
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For the sake of simplicity, we show HO" in Scheme 1. However, the mechanism does not necessarily depend on HO'; it only requires an activated species from ONOOH.
-
For the sake of simplicity, we show HO" in Scheme 1. However, the mechanism does not necessarily depend on HO'; it only requires an activated species from ONOOH.
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note
-
A reviewer asked if ONOOCO2~ could react with ONOO", forming NO and other products as shown in eq i ONOOCO2" + ONOCT -CO32~ + NO2~ + O2 + 'NO (i) The adduct ONOOCOr has a very short half-life11-0-14 and a similar adduct, RCH(O")OONO, formed in reactions of ONOO" with aldehydes, does not have significant oxidative capability.296 Therefore, we believe that ONOOCOr does not oxidize ONOO~. Even if ONOOCO2~ would react with peroxynitrite directly, the reaction is indistinguishable from those of HO" and CO3'- with ONOQ- (eq 3).
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-
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65
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0030847510
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Frears, E.; Nazhat, N.; Blake, D.; Symons, M. Free Radical Res. 1997, 27, 31.
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Free Radical Res.
, vol.27
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-
Frears, E.1
Nazhat, N.2
Blake, D.3
Symons, M.4
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66
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-
0343101241
-
-
note
-
The dissociation constant for ONOO~ giving 'NO plus O2" is 0.017 s~', 23a whereas the rate constants for reactions of HO' and COj~ with ONOO- are (4-5) x I0923b'c and 8 x 107 M~' s-', 23c respectively. Therefore, the relative yields of'NO from reactions 3 and 4 depend on pH, carbonate and buffer concentrations, and impurities present in the system.
-
-
-
-
67
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-
0029031661
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-
(a) Vallance, P.; Patton, S.; Bhagat, K.; MacAllister, R.; Radomski, M.; Moncada, S.; Malinski, T. Lancet 1995, 346, 153.
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(1995)
Lancet
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, pp. 153
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Vallance, P.1
Patton, S.2
Bhagat, K.3
MacAllister, R.4
Radomski, M.5
Moncada, S.6
Malinski, T.7
-
68
-
-
0030752432
-
-
(b) Pinsky, D. J.; Patton, S.; Mesaros, S.; Brovkovych, V.; Kubaszewski, E.; Grunfeld, S.; Malinski, T. Cire. Res. 1997, 87, 372.
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(1997)
Cire. Res.
, vol.87
, pp. 372
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-
Pinsky, D.J.1
Patton, S.2
Mesaros, S.3
Brovkovych, V.4
Kubaszewski, E.5
Grunfeld, S.6
Malinski, T.7
-
69
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-
0003400006
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-
NIST: Gaithersburg, MD
-
Ross, A. B.; Mallard, W. G.; Helman, W. P.; Buxton, G. V.; Huie, R. E.; Neta, P. NDRL-NIST Solution Kinetics Database, Ver. 2.0; NIST: Gaithersburg, MD, 1994.
-
(1994)
NDRL-NIST Solution Kinetics Database, Ver. 2.0
-
-
Ross, A.B.1
Mallard, W.G.2
Helman, W.P.3
Buxton, G.V.4
Huie, R.E.5
Neta, P.6
-
70
-
-
0343973031
-
-
note
-
3 may be formed (eq 6) in reactions of peroxynitrite in the absence of purposefully added carbonate.
-
-
-
-
71
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0029957643
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-
(a) Caulfield, ]. L.; Singh, S. P.; Wishnok, J. S.; Deen, W. M.; Tannenbaum, S. R. J. Biol Chem. 1996, 277, 25859.
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(1996)
. L.; Singh, S. P.; Wishnok, J. S.; Deen, W. M.; Tannenbaum, S. R. J. Biol Chem.
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, pp. 25859
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-
Caulfield1
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72
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0001373384
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(b) Lewis, R. S.; Tannenbaum, S. R.; Deen, W. M. J. Am. Chem. Soc. 1995, 777, 3933.
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(1995)
J. Am. Chem. Soc.
, vol.777
, pp. 3933
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Lewis, R.S.1
Tannenbaum, S.R.2
Deen, W.M.3
-
73
-
-
0343973032
-
-
note
-
2/MorH system. This is consistent with our hypothesis that peroxynitrite-mediated oxidations are predominantly free radical processes.
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-
-
-
76
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-
33847554339
-
-
2 that we could not observe in our RP-HPLC analysis of the products
-
2 that we could not observe in our RP-HPLC analysis of the products.
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-
-
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77
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0000290819
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Czapski, G.; Holcman, J.; Bielski, B. H. J. J. Am. Chem. Soc. 1994, 116, 11465.
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Czapski, G.1
Holcman, J.2
Bielski, B.H.J.3
-
78
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0032588709
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-
-) causes nitrosation in vivo. 'NO autoxidation generates nitrosating intermediates (like NjOj), and these can react directly with ONOO" (Goldstein, G.; Czapski, G.; Lind, J.; Merényi, G. Chem. Res. Toxicol 1999, 12, 132). Thus, by adding 'NO, one would introduce a peroxynitrite-independent pathway for nitrosation as well as potentially interfering cross reactions. The system the reviewer proposes is even more complex than our system, and finding increased nitrosation, as one would expect, could not be easily interpreted.
-
(1999)
Chem. Res. Toxicol
, vol.12
, pp. 132
-
-
Goldstein, G.1
Czapski, G.2
Lind, J.3
Merényi, G.4
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79
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0022426881
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Prutz, W. A.; Monig, H.; Butler, J.; Land, E. J. Arch. Biochem. Biophys. 1985, 243, 125.
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(1985)
J. Arch. Biochem. Biophys.
, vol.243
, pp. 125
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Prutz, W.A.1
Monig, H.2
Butler, J.3
Land, E.4
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80
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0000480726
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-
Chen, S.-N.; Huffman, M. Z.; Parsons, G. H., Jr. J. Phys. Chem. 1975, 79, 1911.
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(1975)
J. Phys. Chem.
, vol.79
, pp. 1911
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Chen, S.-N.1
Huffman, M.Z.2
Parsons Jr., G.H.3
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