Aspirin and salicylate: An old remedy with a new twist

Circulation

Volumn 102, Issue 17, 2000, Pages 2022-2023

  Wu, Kenneth K ^a  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

Aspirin; Editorials; Salicylates

Indexed keywords

ACETYLSALICYLIC ACID; CYCLIN DEPENDENT KINASE; CYCLOOXYGENASE 2 INHIBITOR; CYTOKINE; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; MESSENGER RNA; PROTEIN P27; PROTEIN P53; RETINOBLASTOMA PROTEIN; SALICYLIC ACID; VASCULAR CELL ADHESION MOLECULE 1;

ACUTE HEART INFARCTION; ARACHIDONIC ACID METABOLISM; CARDIOVASCULAR DISEASE; COLON CANCER; DRUG MECHANISM; EDITORIAL; ENDOTHELIUM CELL; HEART INFARCTION; HUMAN; HUMAN CELL; INFLAMMATION; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS INHIBITION;

EID: 0034711141     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.102.17.2022     Document Type: Editorial

References (18)

1. Aspirin
2. Aspirin use and reduced risk of fatal colon cancer
3. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs
4. Inflammation and the mechanism of action of anti-inflammatory drugs
5. The mechanism of the effect of aspirin on human platelets, I: Acetylation of a particulate fraction protein
6. Acetylation of human endoperoxide synthase-2 by aspirin
7. Selectivity of nonsteroidal anti-inflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase
8. Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents
9. Inhibition of prostaglandin synthesis in man
10. Effect of aspirin on human seminal prostaglandins
11. Suppression of inducible cyclooxygenase-2 gene transcription by aspirin and salicylate
12. The anti-inflammatory agents aspirin and salicylate inhibit the activity if I B kinase β
13. Salicylate inhibit I B-α phosphorylation, endothelial leukocyte adhesion molecule expression and neutrophil transmigration
14. Inhibition of NF-κB by sodium salicylate and aspirin
15. Salicylic acid and aspirin inhibit the activity of RSK2 kinase and repress RSK2-dependent transcription of cyclic AMP response element binding protein-and NF-κB responsive genes
16. Inhibition of vascular smooth muscle cell proliferation by sodium salicylate mediated by upregulation of p21(Waf1) and p27(KiP1)
17. The effect of sodium salicylate and aspirin on NF-κB
18. Transcriptional regulation of the cyclooxygenase-2 gene by diverse ligands in murine osteoblasts