Chemical synthesis and pharmacology of 6- and 7-hydroxylated 2-carbomethoxy-3-(p-tolyl)tropanes: Antagonism of cocaine's locomotor stimulant effects

Journal of Medicinal Chemistry

Volumn 43, Issue 17, 2000, Pages 3283-3294

  Zhao, L ^a   Johnson, K M ^b   Zhang, M ^b   Flippen Anderson, J ^c   Kozikowski, A P ^a  

^a GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

^b University of Texas Medical Branch School of Medicine   (United States)

^c NAVAL RESEARCH LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOPAMINE TRANSPORTER; MAZINDOL; METHYL 7BETA HYDROXY 3ALPHA (4 TOLYL)TROPANE 2BETA CARBOXYLIC ACID; MONOAMINE; NARCOTIC ANTAGONIST; NORADRENALIN; SEROTONIN TRANSPORTER; TROPANE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; COCAINE DEPENDENCE; DOPAMINE UPTAKE; DRUG CONFORMATION; DRUG EFFECT; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HYDROGENATION; LOCOMOTION; MALE; MONOAMINERGIC SYSTEM; MOUSE; NARCOTIC DEPENDENCE; NONHUMAN; RAT; SEROTONIN UPTAKE;

ANIMALS; BINDING, COMPETITIVE; BRAIN; COCAINE; CRYSTALLOGRAPHY, X-RAY; MALE; MICE; MODELS, MOLECULAR; MOTOR ACTIVITY; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; TROPANES;

EID: 0034710706     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm000141b     Document Type: Article

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