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Volumn 273, Issue 1, 2000, Pages 54-61

Downregulation of proapoptotic proteins Bax and Bcl-X(s) in p53 overexpressing hepatocellular carcinomas

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL X; PROTEIN P21; PROTEIN P53;

EID: 0034709564     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2000.2891     Document Type: Article
Times cited : (57)

References (53)
  • 1
    • 0026327539 scopus 로고
    • The role of infection by Opisthorchis viverini, hepatitis B virus and aflatoxin exposure in the etiology of liver cancer in Thailand
    • Srivatanakul P., Parkin D. M., Jiang Y. Z., Khlat M., Kao-Ian U. T., Sontipong S., Wild C. P. The role of infection by Opisthorchis viverini, hepatitis B virus and aflatoxin exposure in the etiology of liver cancer in Thailand. Cancer. 68:1991;2411-2417.
    • (1991) Cancer , vol.68 , pp. 2411-2417
    • Srivatanakul, P.1    Parkin, D.M.2    Jiang, Y.Z.3    Khlat, M.4    Kao-Ian, U.T.5    Sontipong, S.6    Wild, C.P.7
  • 8
    • 0031442701 scopus 로고    scopus 로고
    • Hepatocellular carcinoma: From gene to public health
    • Montesano R., Hainaut P., Wild C. P. Hepatocellular carcinoma: From gene to public health. J. Natl. Cancer Inst. 17:1997;1844-1851.
    • (1997) J. Natl. Cancer Inst. , vol.17 , pp. 1844-1851
    • Montesano, R.1    Hainaut, P.2    Wild, C.P.3
  • 9
    • 0025828517 scopus 로고
    • Selective G to T mutations of p53 gene in hepatocellular carcinoma from southern
    • Bressac B., Kew M., Wands J., Ozturk M. Selective G to T mutations of p53 gene in hepatocellular carcinoma from southern. Nature (London). 350:1991;429-431.
    • (1991) Nature (London) , vol.350 , pp. 429-431
    • Bressac, B.1    Kew, M.2    Wands, J.3    Ozturk, M.4
  • 12
    • 0031465731 scopus 로고    scopus 로고
    • P21/p53, cellular growth control and genomic integrity
    • El-Deiry W. S. p21/p53, cellular growth control and genomic integrity. Curr. Topics Microbiol. Immunol. 227:1998;121-137.
    • (1998) Curr. Topics Microbiol. Immunol. , vol.227 , pp. 121-137
    • El-Deiry, W.S.1
  • 13
    • 0032147077 scopus 로고    scopus 로고
    • Association of downregulation of cyclin D1 and of overexpression of cyclin E with p53 mutation, high tumor grade and poor prognosis in hepatocellular carcinoma
    • Peng S. Y., Chou S. P., Hsu H. C. Association of downregulation of cyclin D1 and of overexpression of cyclin E with p53 mutation, high tumor grade and poor prognosis in hepatocellular carcinoma. J. Hepatol. 29:1998;281-289.
    • (1998) J. Hepatol. , vol.29 , pp. 281-289
    • Peng, S.Y.1    Chou, S.P.2    Hsu, H.C.3
  • 15
    • 0028292480 scopus 로고
    • Identification of a p53-dependent negative response element in the bcl-2 gene
    • Miyashita T., Harigai M., Hanada M., Reed J. C. Identification of a p53-dependent negative response element in the bcl-2 gene. Cancer Res. 54:1994;3134-3135.
    • (1994) Cancer Res. , vol.54 , pp. 3134-3135
    • Miyashita, T.1    Harigai, M.2    Hanada, M.3    Reed, J.C.4
  • 19
    • 0029019717 scopus 로고
    • Telomerase activity in human liver tissues: Comparison between chronic liver disease and hepatocellular carcinomas
    • Tahara H., Nakanishi T., Kitamoto M., Nakashio R., Shay J. W., Tahar E., Kajiyawa G., Ide T. Telomerase activity in human liver tissues: Comparison between chronic liver disease and hepatocellular carcinomas. Cancer Res. 55:1995;2734-2736.
    • (1995) Cancer Res. , vol.55 , pp. 2734-2736
    • Tahara, H.1    Nakanishi, T.2    Kitamoto, M.3    Nakashio, R.4    Shay, J.W.5    Tahar, E.6    Kajiyawa, G.7    Ide, T.8
  • 21
    • 0030745945 scopus 로고    scopus 로고
    • Frequent rearrangements at minisatellite loci dis7 (1p33-35), d7s22 (7q36-ter) and d12s11 (12q24.3-ter) in hepatitis B virus-positive hepatocellular carcinomas from Thai patients
    • Kaplanski C., Srivatanakul P., Wild C. P. Frequent rearrangements at minisatellite loci dis7 (1p33-35), d7s22 (7q36-ter) and d12s11 (12q24.3-ter) in hepatitis B virus-positive hepatocellular carcinomas from Thai patients. Int. J. Cancer. 72:1997;248-257.
    • (1997) Int. J. Cancer , vol.72 , pp. 248-257
    • Kaplanski, C.1    Srivatanakul, P.2    Wild, C.P.3
  • 22
    • 0033033694 scopus 로고    scopus 로고
    • Telomerase reverse transcriptase mRNA expression and telomerase activity in hepatocellular carcinoma
    • Nagao K., Tomimatsu M., Enbo H., Hisatomi H., Hikiji K. J. Telomerase reverse transcriptase mRNA expression and telomerase activity in hepatocellular carcinoma. Gastroenterology. 34:1999;83-87.
    • (1999) Gastroenterology , vol.34 , pp. 83-87
    • Nagao, K.1    Tomimatsu, M.2    Enbo, H.3    Hisatomi, H.4    Hikiji, K.J.5
  • 23
    • 0031870273 scopus 로고    scopus 로고
    • Back to the future: The role of cytochrome c in cell death
    • Zhivotovsky B., Hanson K. P., Orrenius S. Back to the future: The role of cytochrome c in cell death. Cell Death Differ. 5:1998;459-460.
    • (1998) Cell Death Differ. , vol.5 , pp. 459-460
    • Zhivotovsky, B.1    Hanson, K.P.2    Orrenius, S.3
  • 24
    • 0030916669 scopus 로고    scopus 로고
    • The proto-oncogene BCL-2 and its role in regulating apoptosis
    • Kroemer G. The proto-oncogene BCL-2 and its role in regulating apoptosis. Nature Med. 6:1997;614-620.
    • (1997) Nature Med. , vol.6 , pp. 614-620
    • Kroemer, G.1
  • 25
    • 0030941458 scopus 로고    scopus 로고
    • P53, the cellular gatekeeper for growth and division
    • Levine A. J. p53, the cellular gatekeeper for growth and division. Cell. 88:1997;323-331.
    • (1997) Cell , vol.88 , pp. 323-331
    • Levine, A.J.1
  • 27
    • 0028805640 scopus 로고
    • Mutant p53 but not hepatitis B virus × protein is present in hepatitis B virus related human hepatocellular carcinoma
    • Henkler F., Waseem N., Golding M. H. C., Alison M. R., Koshy R. Mutant p53 but not hepatitis B virus × protein is present in hepatitis B virus related human hepatocellular carcinoma. Cancer Res. 55:1995;6084-6091.
    • (1995) Cancer Res. , vol.55 , pp. 6084-6091
    • Henkler, F.1    Waseem, N.2    Golding, M.H.C.3    Alison, M.R.4    Koshy, R.5
  • 28
    • 0028071555 scopus 로고
    • Mutations in the p53 tumor suppressor gene: Clues to cancer epidemiology and molecular pathogenesis
    • Greenblatt M. S., Bennett W. P., Hollstein M., Harris C. C. Mutations in the p53 tumor suppressor gene: Clues to cancer epidemiology and molecular pathogenesis. Cancer Res. 54:1994;4855-4878.
    • (1994) Cancer Res. , vol.54 , pp. 4855-4878
    • Greenblatt, M.S.1    Bennett, W.P.2    Hollstein, M.3    Harris, C.C.4
  • 29
    • 0029845760 scopus 로고    scopus 로고
    • Structure and function of the p53 tumor suppressor gene: Clues for rational cancer therapeutic strategies
    • Harris C. C. Structure and function of the p53 tumor suppressor gene: Clues for rational cancer therapeutic strategies. J. Natl. Cancer Inst. 88:1996;1442-1445.
    • (1996) J. Natl. Cancer Inst. , vol.88 , pp. 1442-1445
    • Harris, C.C.1
  • 30
    • 0031802921 scopus 로고    scopus 로고
    • Keeping an old friend under control: Regulation of p53 stability
    • Kubbutat M. H. G., Vousden K. H. Keeping an old friend under control: Regulation of p53 stability. Mol. Med. Today. 6:1998;250-256.
    • (1998) Mol. Med. Today , vol.6 , pp. 250-256
    • Kubbutat, M.H.G.1    Vousden, K.H.2
  • 32
    • 0027157304 scopus 로고
    • Hepatitis B × antigen and p53 are associated in vitro and in liver tissues from patients with primary hepatocellular carcinoma
    • Feitelson M. A., Zhu M., Duan L. X., London W. T. Hepatitis B × antigen and p53 are associated in vitro and in liver tissues from patients with primary hepatocellular carcinoma. Oncogene. 8:1993;1109-1117.
    • (1993) Oncogene , vol.8 , pp. 1109-1117
    • Feitelson, M.A.1    Zhu, M.2    Duan, L.X.3    London, W.T.4
  • 35
    • 0029987762 scopus 로고    scopus 로고
    • Hepatocellular carcinoma with high proliferation index and a low degree of apoptosis and necrosis are associated with a shortened survival
    • Soini Y., Virkajärvi N., Lehto V. P., Pääkkö P. Hepatocellular carcinoma with high proliferation index and a low degree of apoptosis and necrosis are associated with a shortened survival. Br. J. Cancer. 73:1996;1025-1030.
    • (1996) Br. J. Cancer , vol.73 , pp. 1025-1030
    • Soini, Y.1    Virkajärvi, N.2    Lehto, V.P.3    Pääkkö, P.4
  • 36
    • 0029805529 scopus 로고    scopus 로고
    • Expression of apoptosis, proliferating cell nuclear antigen, and apoptosis-related antigens (bcl-2, c-myc, fas, lewis (y) and p53) in human cholangiocarcinoma and hepatocellular carcinomas
    • Terada T., Nakanuma Y. Expression of apoptosis, proliferating cell nuclear antigen, and apoptosis-related antigens (bcl-2, c-myc, fas, lewis (y) and p53) in human cholangiocarcinoma and hepatocellular carcinomas. Pathol. Int. 46:1996;764-770.
    • (1996) Pathol. Int. , vol.46 , pp. 764-770
    • Terada, T.1    Nakanuma, Y.2
  • 40
    • 0009975004 scopus 로고    scopus 로고
    • Mutation of BCL-2 family proteins in cancer
    • Packham G. Mutation of BCL-2 family proteins in cancer. Apoptosis. 3:1998;75-82.
    • (1998) Apoptosis , vol.3 , pp. 75-82
    • Packham, G.1
  • 43
    • 0027166048 scopus 로고
    • Bcl-2 heterodimerizes in vivo with a conserved homolog, bax, that accelerates programmed cell death
    • Oltvai Z. N., Milliman C. L., Korsmeyer S. J. Bcl-2 heterodimerizes in vivo with a conserved homolog, bax, that accelerates programmed cell death. Cell. 74:1993;609-619.
    • (1993) Cell , vol.74 , pp. 609-619
    • Oltvai, Z.N.1    Milliman, C.L.2    Korsmeyer, S.J.3
  • 44
    • 0030979773 scopus 로고    scopus 로고
    • Double identity for proteins of the Bcl-2 family
    • Reed J. C. Double identity for proteins of the Bcl-2 family. Nature (London). 387:1997;773-776.
    • (1997) Nature (London) , vol.387 , pp. 773-776
    • Reed, J.C.1
  • 45
    • 0033179760 scopus 로고    scopus 로고
    • Bcl-2 family members and the mitochondria in apoptosis
    • Gross A., McDonnell J. M., Korsmeyer S. J. Bcl-2 family members and the mitochondria in apoptosis. Genes Dev. 13:1999;1899-1911.
    • (1999) Genes Dev. , vol.13 , pp. 1899-1911
    • Gross, A.1    McDonnell, J.M.2    Korsmeyer, S.J.3
  • 46
    • 0032528118 scopus 로고    scopus 로고
    • Enforced dimerization of bax results in its translocation, mitochondrial dysfunction and apoptosis
    • Gross A., Jockel J., Wei M. C., Korsmeyer S. J. Enforced dimerization of bax results in its translocation, mitochondrial dysfunction and apoptosis. EMBO J. 17:1998;3878-3885.
    • (1998) EMBO J. , vol.17 , pp. 3878-3885
    • Gross, A.1    Jockel, J.2    Wei, M.C.3    Korsmeyer, S.J.4
  • 47
    • 0033573961 scopus 로고    scopus 로고
    • Biophysical characterization of the oligomeric state of bax and its complex formation with bcl-xl
    • Tan Y. J., Beerheide W., Ting A. T. Biophysical characterization of the oligomeric state of bax and its complex formation with bcl-xl. Biochem. Biophys. Res. Commun. 255:1999;334-339.
    • (1999) Biochem. Biophys. Res. Commun. , vol.255 , pp. 334-339
    • Tan, Y.J.1    Beerheide, W.2    Ting, A.T.3
  • 48
    • 0028944271 scopus 로고
    • Expression of the bcl-2 gene family in normal and malignant breast tissue: Low bax-α expression in tumor cells correlates with resistance toward apoptosis
    • Bargou R. C., Daniel P. T., Mapara M. Y., Bommert K., Wagener C., Kallinich B., Royer H. D., Dörken B. Expression of the bcl-2 gene family in normal and malignant breast tissue: Low bax-α expression in tumor cells correlates with resistance toward apoptosis. Int. J. Cancer. 60:1995;854-859.
    • (1995) Int. J. Cancer , vol.60 , pp. 854-859
    • Bargou, R.C.1    Daniel, P.T.2    Mapara, M.Y.3    Bommert, K.4    Wagener, C.5    Kallinich, B.6    Royer, H.D.7    Dörken, B.8
  • 49
    • 0029045784 scopus 로고
    • Reduced expression of pro-apoptotic gene bax is associated with poor response rates to chemotherapy and shorter survival in women with metastatic breast adenocarcinoma
    • Krajewski S., Blomqvist C., Franssila K., Krajewska M., Wasenius V-M., Niskanen E., Nordling S., Reed J. C. Reduced expression of pro-apoptotic gene bax is associated with poor response rates to chemotherapy and shorter survival in women with metastatic breast adenocarcinoma. Cancer Res. 55:1995;4471-4478.
    • (1995) Cancer Res. , vol.55 , pp. 4471-4478
    • Krajewski, S.1    Blomqvist, C.2    Franssila, K.3    Krajewska, M.4    Wasenius, V.-M.5    Niskanen, E.6    Nordling, S.7    Reed, J.C.8
  • 50
    • 0030938089 scopus 로고    scopus 로고
    • Bax-deficiency promotes drug resistance and oncogenic transformation by attenuating p53-dependent apoptosis
    • McCurach M. E., Connor T. M. F., Knudson C. M., Korsmeyer S. J., Lowe S. W. Bax-deficiency promotes drug resistance and oncogenic transformation by attenuating p53-dependent apoptosis. Proc. Natl. Acad. Sci. USA. 94:1997;2345-2349.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 2345-2349
    • McCurach, M.E.1    Connor, T.M.F.2    Knudson, C.M.3    Korsmeyer, S.J.4    Lowe, S.W.5
  • 52
  • 53
    • 0344348993 scopus 로고    scopus 로고
    • Analysis of the p53/bax pathway in colorectal cancer: Low bax is a negative prognostic factor in patients with resected liver metastases
    • Sturm I., Köhne C. H., Wolff G., Petrowsky H., Hillebrand T., Hauptmann S., Lorenz M., Dörken B., Daniel P. T. Analysis of the p53/bax pathway in colorectal cancer: Low bax is a negative prognostic factor in patients with resected liver metastases. J. Clin. Oncol. 5:1999;1364-1374.
    • (1999) J. Clin. Oncol. , vol.5 , pp. 1364-1374
    • Sturm, I.1    Köhne, C.H.2    Wolff, G.3    Petrowsky, H.4    Hillebrand, T.5    Hauptmann, S.6    Lorenz, M.7    Dörken, B.8    Daniel, P.T.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.