Is atherosclerosis an infectious disease?;Atherosklerose: Eine infektionskrankheit?

Wiener Klinische Wochenschrift

Volumn 112, Issue 6, 2000, Pages 253-259

  Gottsauner Wolf, Michael ^a   Wexberg, Paul ^a   El Rabadi, Karem ^a   Wojta, Johann ^a   Maurer, Gerald ^a   Huber, Kurt ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; CHLAMYDOPHILA PNEUMONIAE; CIGARETTE SMOKING; CYTOMEGALOVIRUS; DIABETES MELLITUS; HELICOBACTER PYLORI; HERPES VIRUS; HUMAN; HYPERLIPIDEMIA; HYPERTENSION; INFECTION; NONHUMAN; OBESITY; REVIEW; RISK FACTOR;

ANIMALS; ANTIBODIES, BACTERIAL; ANTIBODIES, VIRAL; ARTERIOSCLEROSIS; CHLAMYDIA INFECTIONS; CHLAMYDOPHILA PNEUMONIAE; CORONARY DISEASE; CYTOMEGALOVIRUS INFECTIONS; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HERPESVIRIDAE INFECTIONS; HUMANS; INFECTION; INFLAMMATION;

EID: 0034708612     PISSN: 00435325     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (66)

1. Napoli C, D'Armiento F, Mancini F, et al (1997) Fatty streak formation occurs in human fetal aortas and is greatly enhanced by maternal hypercholesterolemia: intimal accumulation of low density lipoprotein and its oxidation precede monocyte recruitment into early atherosclerotic lesions. J Clin Invest 100: 2680-2690
2. Ross R (1999) Atherosclerosis - an inflammatory disease. N Engl J Med 340: 115-126
3. Danesh J, Collins R, Peto R (1997) Chronic infections and coronary heart disease: is there a link? Lancet 350: 430-436
4. Kaunitz H (1970) Unorthodox reflections about arteriosclerosis. Wien Klin Wochenschr 82: 825-828
5. Libby P, Egan D, Skarlatos S (1997) Roles of infectious agents in atherosclerosis and restenosis: an assessment of the evidence and need for future research. Circulation 96: 4095-4103
6. O'Brien KD, McDonald TO, Chait A, Allen MD, Alpers CE (1996) Neovascular expression of E-selectin, intercellular adhesion molecule-1, and vascular cell adhesion molecule-1 in human atherosclerosis and their relation to intimal leukocyte content. Circulation 93: 672-682
7. Taubman MB, Fallon JT, Schecter AD, Giesen P, Mendlowitz M, Fyfe BS, Marmur JD, Nemerson Y (1997) Tissue factor in the pathogenesis of atherosclerosis. Thromb Haemost 78: 200-204
8. Muller WA, Weigl SA, Deng X, Phillips DM (1993) PECAM-1 is required for transendothelial migration of leukocytes. J Exp Med 178: 449-460
9. Giachelli CM, Lombardi D, Johnson RJ, Murry CE, Almeida M (1998) Evidence for a role of osteopontin in macrophage infiltration in response to pathological stimuli in vivo. Am J Pathol 152: 353-358
10. Kaartinen M, van der Wal AC, van der Loos CM, Piek JJ, Koch KT, Becker AE, Kovanen PT (1998) Mast cell infiltration in acute coronary syndromes: implications for plaque rupture. J Am Coll Cardiol 32: 606-612
11. Herren B, Raines EW, Ross R (1997) Expression of a disintegrin-like protein in cultured human vascular cells and in vivo. Faseb J 11: 173-180
12. Ridker PM, Cushman M, Stampfer MJ, Tracy RP, Hennekens CH (1997) Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men. N Engl J Med 336: 973-979
13. Fuster V (1994) Mechanisms leading to myocardial infarction: insights from studies of vascular biology. Circulation 90: 2126-2146
14. Lee RT, Libby P (1997) The unstable atheroma. Arterioscler Thromb Vasc Biol 17: 1859-1867
15. Casscells W, Hathorn B, David M, Krabach T, Vaughn WK, McAllister HA, Bearman G, Willerson JT (1997) Thermal detection of cellular infiltrates in living atherosclerotic plaques: possible implications for plaque rupture and thrombosis. Lancet 347: 1447-1451
16. Kaplan AP, Joseph K, Shibayama Y, Reddigari S, Ghebrehiwet B, Silverberg M (1997) The intrinsic coagulation/ kinin-forming cascade: assembly in plasma and cell surfaces in inflammation. Adv Immuno 66: 225-272
17. Herwald H, Morgelin M, Olsen A, Rhen M, Dahlback B, Muller Esterl W, Bjorck L (1998) Activation of the contact-phase system on bacterial surfaces - a clue to serious complications in infectious diseases. Nat Med 4: 298-302
18. Hendrix M, Salimans M, van Boven C, Bruggeman C (1990) High prevalence of latently present cytomegalovirus in arterial walls of patients suffering from grade III atherosclerosis. Am J Pathol 136: 23-28
19. Ossei-Gerning N, Moayyedi P, Smith S, Braunholtz D, Wilson JI, Axon AT, Grant PJ (1997) Helicobacter pylori infection is related to atheroma in patients undergoing coronary angiography. Cardiovascular Res 35: 120-124
20. Jackson LA, Campbell LA, Schmidt RA, Kuo CC, Cappuccio AL, Lee MJ, Grayston JT (1997) Specificity of detection of Chlamydia pneumoniae in cardiovascular atheroma: evaluation of the innocent bystander hypothesis. Am J Pathol 150: 1785-1790
21. Melnick J, Adam E, Debakey M (1997) Cytomegalovirus and atherosclerosis. Eur Heart J 14: 30-38
22. Zhou Y, Leon M, Waclawiw M, Popma J, Yu Z, Finkel T, Epstein S (1996) Association between prior cytomegalovirus infection and the risk of restenosis alter coronary atherectomy. N Eng J Med 335: 624-630
23. Heiss G, Sharrett A, Barnes R, Chambless L, Szklo M, Alzola C (1991) Carotid atherosclerosis measured by B-mode ultrasound in populations: associations with cardiovascular risk factors in the ARIC study. Am J Epidemiol 134: 250-256
24. Galloway D, McDougall J (1983) The oncogenic potential of herpes simplex viruses: evidence for a "hit-and-run" mechanism. Nature 302: 21-24
25. Hendrix M, Dormans P, Kitslaar P, Bosman F, Bruggeman C (1989) The presence of cytomegalovirus nucleic acids in arterial walls of atherosclerotic and nonatherosclerotic patients. Am J Pathol 134: 1151-1157
26. Hendrix M, Daemen M, Bruggeman C (1991) Cytomegalovirus nucleic acid distribution within the human vascular tree. Am J Pathol 138: 563-567
27. Ossewaarde JM, Feskens EJM, DeVries A, Vallinga CE, Kromhout D (1998) Chlamydia pneumoniae is a risk factor for coronary heart disease in symptom-free elderly men, but Helicobacter pylori and cytomegalovirus are not. Epidemiol Inf 120: 93-99
28. Lam KM, Khan M (1997) Cytomegalovirus in transplantation: new developments. Coron Artery Dis 8: 305-316
29. Mendall MA, Goggin PM, Molineaux N, Levy J, Toosy T, Strachan D, Camm AJ, Northfield TC (1994) Relation of Helicobacter pylori infection and coronary heart disease. Br Heart J 71: 437-439
30. Regnstrom J, Jovinge S, Bavenholm P, Ericsson CG, DeFaire U, Hamsten A, Hellenius ML, Nilsson J, Tornvall P (1998) Helicobacter pylori seropositivity is not associated with inflammatory parameters, lipid concentrations and degree of coronary artery disease. J Int Med 243: 109-113
31. Folsom AR, Nieto FJ, Sorlie P, Chambless LE, Graham DY (1998) Helicobacter pylori seropositivity and coronary heart disease incidence. Circulation 98: 845-850
32. Birnie DH, Holme ER, McKay IC, Hood S, McColl KEL, Hillis WC (1998) Association between antibodies to heat shock protein 65 and coronary arterosclerosis: possible mechanism of action of Helicobacter pylori and other bacterial infections in increasing cardiovascular risk. Eur Heart J 1998; 19: 387-394
33. Gupta S (1999) Chronic infection in the aetiology of atherosclerosis - focus on Chlamydia pneumoniae. Atherosclerosis 143: 1-6
34. Saikku P, Leinonen M, Mattila K, Ekman MR, Nieminen MS, Makela PH, Huttunen JK, Valtonen V (1988) Serological evidence of an association of a novel Chlamydia, TWAR, with chronic coronary heart disease and acute myocardial infarction. Lancet ii: 983-986
35. Thorn DH, Wang SP, Grayston JT, Siscovick DS, Stewart DK, Kronmal RA, Weiss NS (1991) Chlamydia pneumoniae strain TWAR antibody and angiographically demonstrated coronary artery disease. Arterioscler Thromb 11: 547-551
36. Saikku P, Leinonen M, Tenkanen L, Linnanmaki E, Ekman M, Manninen V, Manttari Frick M, Huttunen J (1992) Chronic Chlamydia pneumoniae infection as a risk factor for coronary heart disease in the Helsinki Heart Study. Ann Intern Med 116: 273-278
37. Linnanmaki E, Leinonen M, Mattila K, Nieminen MS, Valtonen V, Saikku P. (1993) Chlamydia pneumoniae-specific circulating immune complexes in patients with chronic coronary heart disease. Circulation 87: 1130-1134
38. Melnick SL, Shahar E, Folsom AR, Grayston JT, Sorlie PD, Wang SP, Szklo M (1993) Past infection by Chlamydia pneumoniae strain TWAR and asymptomatic carotid atherosclerosis. Atherosclerosis Risk in Communities (ARIC) Study Investigators. Am J Med 95: 499-504
39. Mendall MA, Carrington D, Strachan D, Patel P, Molineaux N, Levi J, Toosey T, Camm AJ, Northfield TC (1995) Chlamydia pneumoniae: risk factors for seropositivity and association with coronary heart disease. J Infect 30: 121-128
40. Davidson M, Kuo CC, Middaugh JP, Campbell LA, Wang SP, Newman WP, 3rd, Finley JC, Grayston JT (1998) Confirmed previous infection with Chlamydia pneumoniae (TWAR) and its presence in early coronary atherosclerosis. Circulation 98: 628-633
41. Ridker PM, Kundsin RB, Stampfer MJ, Poulin S, Hennekens CH (1999) Prospective study of Chlamydia pneumoniae IgG seropositivity and risks of future myocardial infarction. Circulation 99: 1161-1164
42. Muhlestein J, Hammond E, Carlquist J, Radicke E, Thomson M, Karagounis L, Woods M, Anderson J (1996) Increased incidence of Chlamydia species within the coronary arteries of patients with symptomatic atherosclerotic versus other forms of cardiovascular disease. J Am Coll Cardiol 27: 1555-1561
43. Kuo C, Shor A, Campbell L, Fukushi H, Patton D, Grayston J (1993) Demonstration of Chlamydia pneumoniae in atherosclerotic lesions of coronary arteries. J Infect Dis 167: 841-849
44. Kuo C, Grayston J, Campbell L, Goo Y, Wissler R, Benditt E (1995) Chlamydia pneumoniae (TWAR) in coronary arteries of young adults (15-34 years old). Proc Natl Acad Sci USA 92: 6911-6914
45. Nadrchal R, Makristathis A, Apfalter P, Rotter M, Trubel W, Huk I, Polterauer P, Hirschl AM (1999) Detection of Chlamydia pneumoniae DNA in atheromatous tissues by polymerase chain reaction. Wien Klin Wochenschr 111: 153-156
46. Bauriedel O, Welsch U, Likungu JA, Welz A, Luderitz B (1999) Chlamydia pneumoniae in coronary plaques: increased detection with acute coronary syndrome. Dtsch Med Wochenschr 124: 375-380
47. Wong Y, Thomas M, Tsang V, Gallagher PJ, Ward ME (1999) The prevalence of Chlamydia pneumoniae in atherosclerotic and nonatherosclerotic blood vessels of patients attending for redo and first time coronary artery bypass graft surgery. J Am Coll Cardiol 33: 152-156
48. Muhlstein JB, Anderson JL, Hammond EH, Zhao L, Trehan S, Schwobe EP, Carlquist JF (1998) Infection with Chlamydia pneumonia accelerates the development of atherosclerosis and treatment with azithromycin prevents it in a rabbit model. Circulation 97: 633-636
49. Maass M (1998) Persistence of Chlamydia pneumoniae in human arteriosclerotic plaque substance. Evidence and consequences. Herz 23: 178-184
50. Mayr M, Metzler B, Kiechl S, Willeit J, Schett G, Xu QB, Wick G (1999) Endothelial cytotoxicity mediated by serum antibodies to heat shock proteins of Escherichia coli and Chlamydia pneumoniae - Immune reactions to heat shock proteins as a possible link between infection and atherosclerosis. Circulation 99: 1560-1566
51. La Verda D, Kalayoglu MV, Byrne GL (1999) Chlamydial heat shock proteins and disease pathology: new paradigms for old problems? Infect Dis Obstel Gynecol 71: 64-71
52. Key N, Bach R, Vercellotti G, Moldow C (1993) Herpes simplex virus type I does not require productive infection to induce tissue factor in human umbilical vein endothelial cells. Lab Invest 68: 645-651
53. Fryer RH, Schwobe EP, Woods ML, Rodgers GM (1997) Chlamydia species infect human vascular endothelial cells and induce procoagulant activity. J Investig Med 45: 168-174
54. Kaukoranta Tolvanen SS, Ronni T, Leinonen M, Saikku P Laitinen K (1996) Expression of adhesion molecules on endothelial cells stimulated by Chlamydia pneumoniae. Microb Pathog 21: 407-411
55. Kol A, Bourcier T, Lichtman AH, Libby P (1999) Chlamydial and human heat shock protein 60s activate human vascular endothelium, smooth muscle cells, and macrophages. J Clin Invest 103: 571-577
56. Molestina RE, Dean D, Miller RD, Ramirez JA, Summersgill JT (1998) Characterization of a strain of Chlamydia pneumoniae isolated from a coronary atheroma by analysis of the omp1 gene and biological activity in human endothelial cells. Infect Immun 66: 1370-1376
57. Krull M, Klucken AC, Wuppermann FN, Fuhrmann O, Magerl C, Seybold J, Hippenstiel S, Hegemann JH, Jantos CA, Suttorp N (1999) Signal transduction pathways activated in endothelial cells following infection with Chlamydia pneumoniae. J Immunol 62: 4834-4841
58. Mercurio F, Manning AM (1999) Multiple signals converging on NF-kappaB. Curr Opin Cell Biol 11: 226-232
59. Bachmaier K, Neu N, de la Maza LM, Pal S, Hessel A, Penninger JM (1999) Chlamydia infections and heart disease linked through antigenic mimicry. Science 283: 1335-1339
60. Ojcius DM, Souque P, Perfettini JL, Dautry Varsat A (1998) Apoptosis of epithelial cells and macrophages due to infection with the obligate intracellular pathogen Chlarnydia psittaci. J Immunol 161: 4220-4226
61. Fan T, Lu H, Hu H, Shi L, McClarty GA, Nance DM, Greenberg AH, Zhong G (1998) Inhibition of apoptosis in chlamydia-infected cells: blockade of mitochondrial cytochrome c release and caspase activation. J Exp Med 187: 487-496
62. Gurfinkel E, Bozovich G, Daroca A, Beck E, Mautner B (1997) Randomised trial of roxithromycin in non-Q-wave coronary syndromes: ROXIS Pilot Study. ROXIS Study Group. Lancet 350: 404
63. Gupta S, Leatham EW, Carrington D, Mendall MA, Kaski JC, Camm AJ (1997) Elevated Chlamydia pneumoniae antibodies, cardiovascular events, and azithromycin in male survivors of myocardial infarction. Circulation 96: 404-407
64. Gurfinkel E, Bozovich G, Beck E, Testa E, Livellara B, Mautner B (1999) Treatment with the antibiotic roxithromycin in patients with acute non-Q-wave coronary syndromes - The final report of the ROXIS study. Eur Heart J 20: 121-127
65. Anderson JL, Muhlestein JB, Carlquist J, Allen A, Trehan S, Nielson C, Hall S, Brady J, Egger M, Horne B, Lim T (1999) Randomized secondary prevention trial of azithromycin in patients with coronary artery disease and serological evidence for Chlamydia pneumoniae infection - The azithromycin in coronary artery disease: elimination of myocardial infection with Chlamydia (ACADEMIC) study. Circulation 99: 1540-1547
66. Grayston JT (1999) Antibiotic treatment trials for secondary prevention of coronary artery disease events. Circulation 99: 1538-1539