Cloning of the mouse Pax4 gene promoter and identification of a pancreatic beta cell specific enhancer

Molecular and Cellular Endocrinology

Volumn 170, Issue 1-2, 2000, Pages 79-89

  Xu, Wenzhong ^a   Murphy, Liam J ^a  

^a UNIVERSITY OF MANITOBA   (Canada)

Author keywords

cell specific enhancer; CdxA; DNase 1 footprinting; Nkx 2.2; Pax4

Indexed keywords

TRANSCRIPTION FACTOR;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL LINE; CELL TYPE; CONTROLLED STUDY; DNA FOOTPRINTING; DNA SEQUENCE; ENHANCER REGION; GENETIC ANALYSIS; IN VITRO STUDY; INTRON; MOLECULAR CLONING; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROMOTER REGION; SITE DIRECTED MUTAGENESIS; TRANSCRIPTION REGULATION;

5' UNTRANSLATED REGIONS; ANIMALS; CLONING, MOLECULAR; CODON, INITIATOR; ENHANCER ELEMENTS (GENETICS); HOMEODOMAIN PROTEINS; HUMANS; ISLETS OF LANGERHANS; MICE; MUTAGENESIS, SITE-DIRECTED; PAIRED BOX TRANSCRIPTION FACTORS; PROMOTER REGIONS (GENETICS); RATS; SEQUENCE DELETION; TRANSCRIPTION FACTORS; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0034704349     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0303-7207(00)00329-4     Document Type: Article

References (25)

1. Independent requirement for ISL1 in formation of pancreatic mesenchyme and islet cells
2. Hybrid insulin genes reveal a devlopmental lineage for pancreatic endocrine cells and imply a relationship with neurons
3. Homeosis and intestinal tumours in Cdx2 mutant mice
4. Pax genes and organogenesis
5. Accurate transcription by RNA polymerase II in a soluble extract from isolated mammalian nuclei
6. Onset of cell-specific gene expression in the developing mouse pancreas
7. Isolation of full-length cDNA of mouse PAX4 gene and identification of its human homologue
8. Early specification of intestinal epithelium in the chicken embryo: a study on the localization and regulation of CdxA expression
9. A PCR-based method for high stringency screening of DNA libraries
10. The caudal homeobox protein cdx-2/3 activates endogenous proglucagon gene expression in INR1-G9 islet cells
11. The caudal-related homeodomain protein Cdx-2/3 regulates glucagon gene expression in islet cells
12. On the origin of pancreatic endocrine cells
13. Molecular cloning of mouse paired-box-containing gene (Pax)-4 from an islet cell line and deduced sequence of human Pax-4
14. Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/neuroD-deficient mice
15. PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum
16. Demarcation of ventral territories by the homeobox gene NKX2.1 during early chick development
17. Characterization of the murine A1 adenosine receptor promoter, potent regulation by GATA-4 and Nkx2.5
18. Context-dependent transcriptional cooperation mediated by cardiac transcription factors Csx/Nkx-2.5 and GATA-4
19. The Pax4 gene is essential for differentiation of insulin-producing beta cells in the mammalian pancreas
20. Pax6 is required for differentiation of glucagon-producine alpha-cells in mouse pancreas
21. Disruption of the murine homeobox gene Cdx1 affects axial skeletal identities by altering the mesodermal expression domains of Hox genes
22. Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic beta cells
23. The cardiac homeobox gene Csx/Nkx2.5 lies genetically upstream of multiple genes essential for heart development
24. Isolation and characterization of the human PAX4 gene
25. Pax: amurine multigene family of paired box-containing genes