Contractile depression and expression of proinflammatory cytokines and iNOS in viral myocarditis

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 274, Issue 1 43-1, 1998, Pages

  Freeman, Gregory L ^a   Colston, James T ^a   Zabalgoitia, Miguel ^a   Chandrasekar, Bysani ^a  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

Coxsackievirus; Inducible nitric oxide synthase; Mice; Myocardial contraction

Indexed keywords

INTERLEUKIN 1BETA; INTERLEUKIN 6; NITRIC OXIDE SYNTHASE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; CONTROLLED STUDY; COXSACKIE VIRUS B3; GENE EXPRESSION; HEART CONTRACTION; IMMUNOHISTOCHEMISTRY; INFLAMMATION; MOUSE; MYOCARDITIS; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; VIRUS MYOCARDITIS;

EID: 33750846633     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.1998.274.1.h249     Document Type: Article

References (37)

1. Allred, D. C., G. M. Clark, R. Elledge, S. A. W. Fuqua, R. W. Brown, G. C. Chamness, C. K. Osborne, and W. L. McGuire. Association of p53 protein expression with tumor cell proliferation rate and clinical outcome in node-negative breast cancer. J. Natl. Cancer Inst. 85: 200-206, 1993.
2. Baeuerle, P. A., and D. Baltimore. The physiology of the NF-κB transcription factor. In: Molecular Aspects of Cellular Regulation, Hormonal Control, Regulation of Gene Transcription, edited by P. Cohen and J. G. Foulkes. Amsterdam: Elsevier, 1991, p. 409-432.
3. Balligand, J.-L., D. Ungureanu, R. A. Kelly, L. Kobzik, D. Pimental, T. Michel, and T. M. Smith. Abnormal contractile function due to induction of nitric oxide synthesis in rat cardiac myocytes follows exposure to activated macrophage-conditioned medium. J. Clin. Invest. 91: 2314-2319, 1993.
4. Berent, S. L., R. M. Torczynski, and A. P. Bollon. Sendai virus induces high levels of tumor necrosis factor mRNA in human peripheral blood leukocytes. Nucleic Acids Res. 22: 8997-9015, 1986.
5. Brady, A. J. B., P.A. Poole-Wilson, S. E. Harding, and J. B. Warren. Nitric oxide production within cardiac myocytes reduces their contractility in endotoxemia. Am. J. Physiol. 263 (Heart Circ. Physiol. 32): H1963-H1966, 1992.
6. Chandrasekar, B., J. T. Colston, and G. L. Freeman. Induction of proinflammatory cytokine and antioxidant enzyme gene expression following brief myocardial ischemia. Clin. Exp. Immunol. 108: 346-351, 1997.
7. Chandrasekar, B., and G. L. Freeman. Induction of nuclear factor κB and activation protein 1 in postischemic myocardium. FEBS Lett. 401: 30-34, 1997.
8. Chandrasekar, B., P. C. Melby, D. A. Troyer, and G. L. Freeman. Induction of proinflammatory cytokine expression in experimental acute Chagasic cardiomyopathy. Biochem. Biophys. Res. Commun. 223: 365-371, 1996.
9. Chandrasekar, B., J. E. Streitman, J. T. Colston, and G. L. Freeman. Inhibition of nuclear factor κB attenuates proinflammatory cytokine and inducible nitric oxide synthase expression in postischemic myocardium. Biochim. Biophys. Acta. In press.
10. Crystal, G. J., and J. Gurevicius. Nitric oxide does not modulate myocardial contractility acutely in in situ canine hearts. Am. J. Physiol. 270 (Heart Circ. Physiol. 39): H1568-H1576, 1996.
11. Finkel, M. S., C. V. Oddis, T. D. Jacob, S. C. Watkins, B. G. Hattler, and R. L. Simmons. Negative inotropic effects of cytokines on the heart mediated by nitric oxide. Science 257: 387-389, 1992.
12. Geller, D. A., A. K. Nussler, M. Di Silvio, C. J. Lowenstein, R. A. Shapiro, S. C. Wang, R. L. Simmons, and T. R. Billiar. Cytokines, endotoxin, and glucocorticoids regulate the expression of inducible nitric oxide synthase in hepatocytes. Proc. Natl. Acad. Sci. USA 90: 522-526, 1993.
13. Goldfeld, A. E., and T. Maniatis. Coordinate viral induction of tumor necrosis factor-α and interferon-β in human B cells and monocytes. Proc. Natl. Acad. Sci. USA 86: 1490-1494, 1989.
14. Habib, F. M., D. R. Springall, G. J. Davies, C. M. Oakley, M. H. Yacoub, and J. M. Polak. Tumor necrosis factor and inducible nitric oxide synthase in dilated cardiomyopathy. Lancet 347: 1151-1155, 1996.
15. Haywood, G. A., P. S. Tsao, H. E. von der Leyen, M. J. Mann, P. J. Keeling, P. T. Trinidade, N. P. Lewis, C. D. Byrne, P. R. Rickenbacher, N. H. Bishopric, J. P. Cooke, W. J. McKenna, and M. B. Fowler. Expression of inducible nitric oxide synthase in human heart failure. Circulation 93: 1087-1094, 1996.
16. Henke, A., M. Carsten, H. Sprenger, C. Graebner, A. Stelzner, M. Nain, and D. Gemsa. Coxsackievirus B3-induced production of tumor necrosis factor-α, IL-1β, and IL-6 in human monocytes. J. Immunol. 148: 2270-2277, 1992.
17. Herskowitz, A., S. Choi, A. A. Ansari, and S. Wesselingh. Cytokine mRNA expression in postischemic/reperfused myocardium. Am. J. Pathol. 146: 419-428, 1995.
18. Herzum, M., R. Weller, H. Jomaa, F. Wietrzychowski, S. Pankuweit, P. Mahr, and B. Maisch. Left ventricular hemodynamic parameters in the course of acute experimental coxsackievirus B3 myocarditis. J. Mol. Cell. Cardiol. 27: 1573-1580, 1995.
19. Hiraoka, Y., C. Kishimoto, H. Takada, M. Kurokawa, H. Ochiai, K. Shirakai, and S. Sasayama. Role of oxygen derived free radicals in the pathogenesis of coxsackievirus B3 myocarditis in mice. Cardiovasc. Res. 27: 957-961, 1993.
20. Hosenpud, J. D. The effects of interleukin-1 on myocardial function and metabolism. Clin. Immunol. Immunopathol. 68: 175-180, 1993.
21. Korc, M., B. Chandrasekar, Y. Yamanaka, H. Friess, M. Buchler, and H. G. Beger. Overexpression of epidermal growth factor receptor in human pancreatic cancer is associated with concomitant increases in the levels of epidermal growth factor and transforming growth factor-α. J. Clin. Invest. 90: 1352-1360, 1992.
22. Kuprash, D. V., I. A. Udalova, R. L. Turetskaya, N. R. Rice, and S. A. Nedospasov. Conserved κB element located downstream of tumor necrosis factor-α gene: distinct NF-κB binding pattern and enhancer activity in LPS activated murine macrophages. Oncogene 11: 97-106, 1990.
23. Lane, J. R., D. A. Neumann, A. LaFond-Walker, A. Herskowitz, and N. R. Rose. Interleukin-1 or tumor necrosis factor can promote coxsackie B3-induced myocarditis in resistant B10.A mice. J. Exp. Med. 175: 1123-1129, 1992.
24. Lenardo, M. J., and D. Baltimore. NF-κB: a pleiotropic mediator of inducible and tissue-specific gene control. Cell 58: 227-229, 1989.
25. Lieberman, T. A., and D. Baltimore. Activation of interleukin-6 gene expression through the NF-κB transcription factor. Mol. Cell. Biol. 10: 2327-2334, 1990.
26. Lowenstein, C. J., S. L. Hill, A. Lafond-Walker, J. Wu, G. Allen, M. Landavere, N. R. Rose, and A. Herskowitz. Nitric oxide inhibits viral replication in murine myocarditis. J. Clin. Invest. 97: 1837-1843, 1996.
27. Mikami, S., S. Kawashima, K. Kanazawa, K. Hirata, Y. Katayama, H. Hotta, Y. Hayashi, H. Ito, and M. Yokoyama. Expression of nitric oxide synthase in a murine model of viral myocarditis induced by coxsackievirus B3. Biochem. Biophys. Res. Commun. 220: 983-989, 1996.
28. Murray, D. R., and G. L. Freeman. Tumor necrosis factor-α induces a biphasic effect on myocardial contractility in conscious dogs. Circ. Res. 78: 154-160, 1996.
29. National Institutes of Health. Guide for the Care and Use of Laboratory Animals. Bethesda, MD: Office of Science and Health Reports, revised 1985. [DHEW Publ. (NIH) 85-23]
30. Neumann, D. A., J. R. Lane, G. S. Allen, A. Herskowitz, and N. R. Rose. Viral myocarditis leading to cardiomyopathy: do cytokines contribute to pathogenesis? Clin. Immunol. Immunopathol. 68: 181-190, 1993.
31. Sato, S., R. Tsutsumi, A. Burke, G. Carlson, V. Porro, Y. Seko, K. Okumura, R. Kawana, and R. Virmani. Persistence of replicating coxsackievirus B3 in the athymic murine heart is associated with development of myocarditic lesions. J. Gen. Virol. 75: 2911-2924, 1994.
32. Schulz, R., D. L. Panas, R. Catena, S. Moncada, P. M. Olley, and G. D. Lopaschuk. The role of nitric oxide in cardiac depression induced by interleukin-1β and tumor necrosis factor-α. Br. J. Pharmacol. 114: 27-34, 1995.
33. Sobotka, P. A., J. McMannis, R. I. Fisher, D. G. Stein, and J. X. Thomas, Jr. Effects of interleukin-2 on cardiac function in the isolated rat heart. J. Clin. Invest. 86: 845-850, 1990.
34. Ungureanu-Longrois, D., J.-L. Balligand, R. A. Kelley, and T. W. Smith. Myocardial contractile dysfunction in the systemic inflammatory response syndrome: role of cytokine-inducible nitric oxide synthase in cardiac myocytes. J. Mol. Cell. Cardiol. 27: 155-167, 1995.
35. Xie, Q.-W., Y. Kashiwabara, and C. Nathan. Role of transcription factor NF-κB/Rel in induction of nitric oxide synthase. J. Biol. Chem. 269: 4705-4709, 1990.
36. Yamada, T., A. Matsumori, and S. Sasayama. Therapeutic effect of anti-tumor necrosis factor-α antibody on the murine model of viral myocarditis induced by encephalomyocarditis virus. Circulation 89: 846-851, 1994.
37. Yokoyama, T., L. Vaca, R. D. Rossen, W. Durante, P. Hazarika, and D. L. Mann. Cellular basis for the negative inotropic effects of tumor necrosis factor-α in the adult mammalian heart. J. Clin. Invest. 92: 2303-2312, 1993.