메뉴 건너뛰기




Volumn 359, Issue 1, 1999, Pages 33-39

Effects of retigabine (D-23129) on different patterns of epileptiform activity induced by 4-aminopyridine in rat entorhinal cortex hippocampal slices

Author keywords

Anticonvulsant; Antiepileptic; Bicuculline; Field potential; New drug; Retigabine

Indexed keywords

2 AMINO 5 PHOSPHONOVALERIC ACID; 4 AMINOPYRIDINE; 6 NITRO 7 SULFAMOYLBENZO[F]QUINOXALINE 2,3 DIONE; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; BICUCULLINE; CARBAMAZEPINE; GLUTAMATE RECEPTOR; KAINIC ACID; N METHYL DEXTRO ASPARTIC ACID; PENICILLIN G; PENTETRAZOLE; PHENYTOIN; PICROTOXIN; RETIGABINE; VALPROIC ACID;

EID: 0033032546     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/PL00005320     Document Type: Article
Times cited : (53)

References (45)
  • 1
    • 0029948787 scopus 로고    scopus 로고
    • Synchronous GABA-mediated potentials and epileptiform discharges in the rat limbic system in vitro
    • Avoli M, Barbarosie M, Lücke A, Nagao T, Lopantsev V, Köhling R (1996) Synchronous GABA-mediated potentials and epileptiform discharges in the rat limbic system in vitro. J Neurosci 16:3912-3924
    • (1996) J Neurosci , vol.16 , pp. 3912-3924
    • Avoli, M.1    Barbarosie, M.2    Lücke, A.3    Nagao, T.4    Lopantsev, V.5    Köhling, R.6
  • 3
    • 0021856427 scopus 로고
    • Anticonvulsant drugs and genetically epilepsy-prone rat
    • Dailey JW, Jobe PC (1985) Anticonvulsant drugs and genetically epilepsy-prone rat. Fed Proc 44:2640-2644
    • (1985) Fed Proc , vol.44 , pp. 2640-2644
    • Dailey, J.W.1    Jobe, P.C.2
  • 4
    • 0029086889 scopus 로고
    • Anticonvulsant properties of D-20443 in genetically epilepsy-prone rats: Prediction of clinical response
    • Dailey JW, Cheong JH, Ko KH, Adams-Curtis LE, Jobe PC (1995) Anticonvulsant properties of D-20443 in genetically epilepsy-prone rats: Prediction of clinical response. Neurosci Lett 195:77-80
    • (1995) Neurosci Lett , vol.195 , pp. 77-80
    • Dailey, J.W.1    Cheong, J.H.2    Ko, K.H.3    Adams-Curtis, L.E.4    Jobe, P.C.5
  • 5
    • 0025119256 scopus 로고
    • Late low magnesium-induced epileptiform activity in rat entorthinal cortex slices becomes insensitive to the anticonvulsant valproic acid
    • Dreier JP, Heinemann U (1990) Late low magnesium-induced epileptiform activity in rat entorthinal cortex slices becomes insensitive to the anticonvulsant valproic acid. Neurosci Lett 119:68-70
    • (1990) Neurosci Lett , vol.119 , pp. 68-70
    • Dreier, J.P.1    Heinemann, U.2
  • 6
    • 0026501024 scopus 로고
    • Slow and fast transient potassium currents in cultured rat hippocampal cells
    • Ficker E, Heinemann U (1992) Slow and fast transient potassium currents in cultured rat hippocampal cells. J Physiol (Lond) 445:431-455
    • (1992) J Physiol (Lond) , vol.445 , pp. 431-455
    • Ficker, E.1    Heinemann, U.2
  • 7
    • 0026666306 scopus 로고
    • Effects of antiepileptic drugs on 4-aminopyridine-induced epileptiform activity in young and adult rat hippocampus
    • Fueta Y, Avoli M (1992) Effects of antiepileptic drugs on 4-aminopyridine-induced epileptiform activity in young and adult rat hippocampus. Epilepsy Res 12:207-215
    • (1992) Epilepsy Res , vol.12 , pp. 207-215
    • Fueta, Y.1    Avoli, M.2
  • 8
    • 0028982429 scopus 로고
    • 2+ induced epileptiform activity in rat hippocampal and entorhinal cortex slices during adolescence
    • 2+ induced epileptiform activity in rat hippocampal and entorhinal cortex slices during adolescence. Brain Res Dev Brain Res 87:145-152
    • (1995) Brain Res Dev Brain Res , vol.87 , pp. 145-152
    • Gloveli, T.1    Albrecht, D.2    Heinemann, U.3
  • 9
    • 0019947819 scopus 로고
    • A transient outward current in a mammalian central neurone blocked by 4-aminopyridine
    • Gustafsson B, Galvan M, Grafe P, Wigström H (1982) A transient outward current in a mammalian central neurone blocked by 4-aminopyridine. Nature 299:252-254
    • (1982) Nature , vol.299 , pp. 252-254
    • Gustafsson, B.1    Galvan, M.2    Grafe, P.3    Wigström, H.4
  • 10
    • 0029016078 scopus 로고
    • Febrile seizures and hippocampal sclerosis: Frequent and related findings in intractable temporal lobe epilepsy of childhood
    • Harvey AS, Grattan-Smith JD, Desmond PM, Chow CW, Berkovic SF (1995) Febrile seizures and hippocampal sclerosis: frequent and related findings in intractable temporal lobe epilepsy of childhood. Pediatr Neurol 12:201-206
    • (1995) Pediatr Neurol , vol.12 , pp. 201-206
    • Harvey, A.S.1    Grattan-Smith, J.D.2    Desmond, P.M.3    Chow, C.W.4    Berkovic, S.F.5
  • 12
    • 0028022008 scopus 로고
    • Strategies for the development of drugs for pharmacoresistant epilepsies
    • Heinemann U, Draguhn A, Ficker E, Stabel J, Zhang CL (1994). Strategies for the development of drugs for pharmacoresistant epilepsies. Epilepsia. 35 [Suppl 5]:S10-S21
    • (1994) Epilepsia , vol.35 , Issue.SUPPL. 5
    • Heinemann, U.1    Draguhn, A.2    Ficker, E.3    Stabel, J.4    Zhang, C.L.5
  • 14
    • 0029855407 scopus 로고    scopus 로고
    • D-23129: A new anticonvulsant compound
    • Kapetanovic IM, Rundfeldt C (1996) D-23129: A new anticonvulsant compound. CNS Drug Rev 2:308-321
    • (1996) CNS Drug Rev , vol.2 , pp. 308-321
    • Kapetanovic, I.M.1    Rundfeldt, C.2
  • 15
    • 0028806375 scopus 로고
    • The effects of D-23129, a new experimental anticonvulsant drug, on neurotransmitter amino acids in the rat hippocampus in vivo
    • Kapetanovic IM, Yonekawa WD, Kupferberg HJ (1995) The effects of D-23129, a new experimental anticonvulsant drug, on neurotransmitter amino acids in the rat hippocampus in vivo. Epilepsy Res 22:167-173
    • (1995) Epilepsy Res , vol.22 , pp. 167-173
    • Kapetanovic, I.M.1    Yonekawa, W.D.2    Kupferberg, H.J.3
  • 16
    • 0023615028 scopus 로고
    • Anticonvulsive properties of ketamine and 2-aminophosphono-valerate in the low magnesium epilepsy in rat hippocampal slices
    • Köhr G, Heinemann U (1987) Anticonvulsive properties of ketamine and 2-aminophosphono-valerate in the low magnesium epilepsy in rat hippocampal slices. Neurosci Res Commun 1:17-21
    • (1987) Neurosci Res Commun , vol.1 , pp. 17-21
    • Köhr, G.1    Heinemann, U.2
  • 17
    • 0028220347 scopus 로고
    • Strategies in antiepileptic drug development: Is rational drug design superior to random screening and structural variation?
    • Löscher W, Schmidt D (1994) Strategies in antiepileptic drug development: is rational drug design superior to random screening and structural variation? Epilepsy Res 17:95-134
    • (1994) Epilepsy Res , vol.17 , pp. 95-134
    • Löscher, W.1    Schmidt, D.2
  • 18
    • 0025993649 scopus 로고
    • Trans-2-envalproate: Re-evaluation of its anticonvulsant efficacy in standardized seizure models in mice, rats and dogs
    • Löscher W, Hönack D, Nolting B, Fassbender CP (1991) Trans-2-envalproate: re-evaluation of its anticonvulsant efficacy in standardized seizure models in mice, rats and dogs. Epilepsy Res 9:195-210
    • (1991) Epilepsy Res , vol.9 , pp. 195-210
    • Löscher, W.1    Hönack, D.2    Nolting, B.3    Fassbender, C.P.4
  • 19
    • 0028059486 scopus 로고
    • Tiagabine
    • Mengel H (1994) Tiagabine. Epilepsia 35 [suppl 5]:S81-S84
    • (1994) Epilepsia , vol.35 , Issue.SUPPL. 5
    • Mengel, H.1
  • 22
    • 0025802127 scopus 로고
    • Physiology and pharmacology of epileptiform activity induced by 4-aminopyridine in rat hippocampal slices
    • Perreault P, Avoli M (1991) Physiology and pharmacology of epileptiform activity induced by 4-aminopyridine in rat hippocampal slices. J Neurophysiol 65:771-785
    • (1991) J Neurophysiol , vol.65 , pp. 771-785
    • Perreault, P.1    Avoli, M.2
  • 23
    • 0025050694 scopus 로고
    • Antiepileptic drugs: Pharmacological mechanism and clinical efficacy with consideration of promising developmental stage compounds
    • Rogawski MA, Porter RJ (1990) Antiepileptic drugs: pharmacological mechanism and clinical efficacy with consideration of promising developmental stage compounds. Pharmacol Rev 42:223-286
    • (1990) Pharmacol Rev , vol.42 , pp. 223-286
    • Rogawski, M.A.1    Porter, R.J.2
  • 25
    • 0030668611 scopus 로고    scopus 로고
    • + channels in neuronal cells
    • + channels in neuronal cells. Eur J Pharmacol 336:243-249
    • (1997) Eur J Pharmacol , vol.336 , pp. 243-249
    • Rundfeldt, C.1
  • 26
    • 0000130273 scopus 로고
    • Multiple actions of the new anticonvulsant D-23129 on voltage-gated inwards currents and GABA-induced currents in cultured neuronal cells
    • Rundfeldt C, Rohlfs A, Netzer R (1995a) Multiple actions of the new anticonvulsant D-23129 on voltage-gated inwards currents and GABA-induced currents in cultured neuronal cells (abstract). Naunyn Schmiedeberg's Arch Pharmacol [Suppl] 351:R160
    • (1995) Naunyn Schmiedeberg's Arch Pharmacol [Suppl] , vol.351
    • Rundfeldt, C.1    Rohlfs, A.2    Netzer, R.3
  • 27
    • 0000171586 scopus 로고
    • Potassium channel opening properties of D-23129 an anticonvulsant with potent effects in rodents models for generalisEd and focal seizures
    • Rundfeldt C, Tober C, Ganguly A, Wolf HH, White HS (1995b) Potassium channel opening properties of D-23129 an anticonvulsant with potent effects in rodents models for generalised and focal seizures (abstract). Soc Neurosci Abstr 21:203
    • (1995) Soc Neurosci Abstr , vol.21 , pp. 203
    • Rundfeldt, C.1    Tober, C.2    Ganguly, A.3    Wolf, H.H.4    White, H.S.5
  • 28
    • 0013585456 scopus 로고    scopus 로고
    • The anticonvulsant D-23129 (retigabine) is effective in a hippocampal slice model of drug resistant epilepsy
    • Rundfeldt C, Armand V, Heinemann U (1997). The anticonvulsant D-23129 (retigabine) is effective in a hippocampal slice model of drug resistant epilepsy (abstract). Soc Neurosci Abstr 840:2162
    • (1997) Soc Neurosci Abstr , vol.840 , pp. 2162
    • Rundfeldt, C.1    Armand, V.2    Heinemann, U.3
  • 29
    • 0023276799 scopus 로고
    • 4-Aminopyridine produces epileptiform activity in hippocampus and enhances synaptic excitation and inhibition
    • Rutecki PA, Lebeda FJ, Johnston D (1987) 4-Aminopyridine produces epileptiform activity in hippocampus and enhances synaptic excitation and inhibition. J Neurophysiol 57:1911-1924
    • (1987) J Neurophysiol , vol.57 , pp. 1911-1924
    • Rutecki, P.A.1    Lebeda, F.J.2    Johnston, D.3
  • 30
    • 0015745156 scopus 로고
    • A summary of the acute toxicity of 4-aminopyridine to birds and mammals
    • Schafer EW, Brunton RB, Cunningham DJ (1973) A summary of the acute toxicity of 4-aminopyridine to birds and mammals. Toxicol Appl Pharmacol 26:532-538
    • (1973) Toxicol Appl Pharmacol , vol.26 , pp. 532-538
    • Schafer, E.W.1    Brunton, R.B.2    Cunningham, D.J.3
  • 31
    • 0028109691 scopus 로고
    • Hippocampal resections and the use of human tissue in defining temporal lobe epilepsy syndromes
    • Spencer DD, Spencer SS (1994) Hippocampal resections and the use of human tissue in defining temporal lobe epilepsy syndromes. Hippocampus 4:243-249
    • (1994) Hippocampus , vol.4 , pp. 243-249
    • Spencer, D.D.1    Spencer, S.S.2
  • 33
    • 0023696536 scopus 로고
    • + current in hippocampal neurones
    • + current in hippocampal neurones. Nature 336:379-381
    • (1988) Nature , vol.336 , pp. 379-381
    • Storm, J.F.1
  • 34
    • 0028855148 scopus 로고
    • The pathophysiology of human mesial temporal lobe epilepsy
    • Swanson TH (1995) The pathophysiology of human mesial temporal lobe epilepsy. J Clin Neurophysiol 12:2-22
    • (1995) J Clin Neurophysiol , vol.12 , pp. 2-22
    • Swanson, T.H.1
  • 35
    • 0019310355 scopus 로고
    • Aminopyridines and synaptic transmission
    • Thesleff S (1980) Aminopyridines and synaptic transmission. Neuroscience 5:1413-1419
    • (1980) Neuroscience , vol.5 , pp. 1413-1419
    • Thesleff, S.1
  • 36
    • 0001208372 scopus 로고
    • The phenyl carbamic acid ester D-23129 is highly effective in epilepsy models for generalised and focal seizures at nontoxic doses
    • Tober C, Rundfeldt C, Rostock A, Bartsch R (1994a) The phenyl carbamic acid ester D-23129 is highly effective in epilepsy models for generalised and focal seizures at nontoxic doses (abstract). Soc Neurosci Abstr 20:1641
    • (1994) Soc Neurosci Abstr , vol.20 , pp. 1641
    • Tober, C.1    Rundfeldt, C.2    Rostock, A.3    Bartsch, R.4
  • 37
    • 0000610751 scopus 로고
    • The phenylcarbamic acid ester D-23129 is highly effective against amygdala-kindled seizures in rats
    • Tober C, Rostock A, Bartsch R (1994b) The phenylcarbamic acid ester D-23129 is highly effective against amygdala-kindled seizures in rats (abstract). Eur J Pharmacol [Suppl] 7:212
    • (1994) Eur J Pharmacol [Suppl] , vol.7 , pp. 212
    • Tober, C.1    Rostock, A.2    Bartsch, R.3
  • 38
    • 0029891002 scopus 로고    scopus 로고
    • D-23129: A potent anliconvulsant in the amygdala kindling model of complex partial seizures
    • Tober C, Rostock A, Rundfeldt C, Bartsch R (1996) D-23129: a potent anliconvulsant in the amygdala kindling model of complex partial seizures. Eur J Pharmacol 303:163-169
    • (1996) Eur J Pharmacol , vol.303 , pp. 163-169
    • Tober, C.1    Rostock, A.2    Rundfeldt, C.3    Bartsch, R.4
  • 39
    • 0022404989 scopus 로고
    • Spontaneous epileptiform discharges in hippocampal slices induced by 4-aminopyridine
    • Voskuyl RA, Albus H (1985) Spontaneous epileptiform discharges in hippocampal slices induced by 4-aminopyridine. Brain Res 342:54-66
    • (1985) Brain Res , vol.342 , pp. 54-66
    • Voskuyl, R.A.1    Albus, H.2
  • 40
    • 0022460724 scopus 로고
    • Epileptiform activity in combined slices of the hippocampus, subiculum and entorhinal cortex during perfusion with low magnesium medium
    • Walther H, Lambert JDC, Jones RSG, Heinemann U, Hamon B (1986) Epileptiform activity in combined slices of the hippocampus, subiculum and entorhinal cortex during perfusion with low magnesium medium. Neurosci Lett 69:156-161
    • (1986) Neurosci Lett , vol.69 , pp. 156-161
    • Walther, H.1    Lambert, J.D.C.2    Jones, R.S.G.3    Heinemann, U.4    Hamon, B.5
  • 41
    • 0026608653 scopus 로고
    • Effects of anticonvulsant drugs on of 4-aminopyridine-induced seizures in mice
    • Yamaguchi S, Rogawski MA (1992) Effects of anticonvulsant drugs on of 4-aminopyridine-induced seizures in mice. Epilepsy Res 11:9-16
    • (1992) Epilepsy Res , vol.11 , pp. 9-16
    • Yamaguchi, S.1    Rogawski, M.A.2
  • 42
    • 0001079795 scopus 로고
    • The effects of D-23129 (ADD 230001) and standard anticonvulsant on the paired-pulse paradigm in rat hippocampus in vitro
    • Yonekawa WD, Kapetanovic IM, Kupferberg HJ (1995a) The effects of D-23129 (ADD 230001) and standard anticonvulsant on the paired-pulse paradigm in rat hippocampus in vitro (abstract). Soc Neurosci Abstr 21:R2117
    • (1995) Soc Neurosci Abstr , vol.21
    • Yonekawa, W.D.1    Kapetanovic, I.M.2    Kupferberg, H.J.3
  • 43
    • 0028843385 scopus 로고
    • The effects of anticonvulsant agents on 4-aminopyridine-induced epileptiform activity in rat hippocampus in vitro
    • Yonekawa WD, Kapetanovic IM, Kupferberg HJ (1995b) The effects of anticonvulsant agents on 4-aminopyridine-induced epileptiform activity in rat hippocampus in vitro. Epilepsy Res 20:137-150
    • (1995) Epilepsy Res , vol.20 , pp. 137-150
    • Yonekawa, W.D.1    Kapetanovic, I.M.2    Kupferberg, H.J.3
  • 44
    • 0001691851 scopus 로고
    • 2+ induced epileptiform activity in rat temporal cortex slices: Development of pharmacoresisianl epileptiform activity
    • 2+ induced epileptiform activity in rat temporal cortex slices: development of pharmacoresisianl epileptiform activity. Pflügers Arch [Suppl] 418:R10
    • (1991) Pflügers Arch [Suppl] , vol.418
    • Zhang, C.L.1    Dreier, J.P.2    Heinemann, U.3
  • 45
    • 0028796891 scopus 로고
    • Paroxysmal epileptiform discharges in temporal Lobe slices after prolonged exposure to low magnesium are resistant to clinically used anticonvulsants
    • Zhang CL, Dreier JP, Heinemann U (1995) Paroxysmal epileptiform discharges in temporal Lobe slices after prolonged exposure to low magnesium are resistant to clinically used anticonvulsants. Epilepsy Res 20:105-111
    • (1995) Epilepsy Res , vol.20 , pp. 105-111
    • Zhang, C.L.1    Dreier, J.P.2    Heinemann, U.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.