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Volumn 295, Issue 3, 2000, Pages 693-707

The kinetic mechanism of the hairpin ribozyme in vivo: Influence of RNA helix stability on intracellular cleavage kinetics

Author keywords

Enzyme mechanism; Hairpin ribozyme; Intracellular kinetics; mRNA degradation; RNA catalysis

Indexed keywords

RIBOZYME; RNA;

EID: 0034695408     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.1999.3380     Document Type: Article
Times cited : (45)

References (83)
  • 5
    • 0026047228 scopus 로고
    • Multiple processing-defective mutations in a histone premessenger RNA are suppressed by compensatory changes in U7 RNA both in vivo and in vitro
    • (1991) Genes Dev. , vol.5 , pp. 1709-1722
    • Bond, U.M.1    Yario, T.A.2    Steitz, J.A.3
  • 6
    • 0021099454 scopus 로고
    • Fate of an intervening sequence ribonucleic acid: Excision and cyclization of the Tetrahymena ribosomal ribonucleic acid intervening sequence in vivo
    • (1983) Biochemistry , vol.22 , pp. 2390-2397
    • Brehm, S.L.1    Cech, T.R.2
  • 9
    • 0028036218 scopus 로고
    • A photo-cross-linkable tertiary structure motif found in functionally distinct RNA molecules is essential for catalytic function of the hairpin ribozyme
    • (1994) Biochemistry , vol.33 , pp. 992-999
    • Butcher, S.E.1    Burke, J.M.2
  • 16
    • 0031583861 scopus 로고    scopus 로고
    • Formation of circular satellite tobacco ringspot virus RNA in protoplasts transiently expressing the linear RNA
    • (1997) Virology , vol.239 , pp. 413-425
    • Chay, C.A.1    Guan, X.2    Bruening, G.3
  • 20
    • 0028036559 scopus 로고
    • Control of translation by mRNA secondary structure in Escherichia coli. A quantitative analysis of literature data
    • (1994) J. Mol. Biol. , vol.244 , pp. 144-150
    • De Smit, M.H.1    Van Duin, J.2
  • 23
    • 0032534533 scopus 로고    scopus 로고
    • Hairpin ribozyme cleavage catalyzed by aminoglycoside antibiotics and the polyamine spermine in the absence of metal ions
    • (1998) Nucl. Acids Res. , vol.26 , pp. 5551-5561
    • Earnshaw, D.J.1    Gait, M.J.2
  • 28
    • 0033600553 scopus 로고    scopus 로고
    • Tertiary structure stabilization promotes hairpin ribozyme ligation
    • (1999) Biochemistry , vol.38 , pp. 11040-11050
    • Fedor, M.J.1
  • 30
    • 0002198148 scopus 로고    scopus 로고
    • The role of metal ions in RNA biochemistry
    • The RNA World (Gesteland, R. F., Cech, T. R. and Atkins, J. F., eds), 2nd edit., Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY
    • (1999) , pp. 287-320
    • Feig, A.L.1    Uhlenbeck, O.C.2
  • 31
    • 0027310473 scopus 로고
    • Catalytically active geometry in the reversible circularization of 'mini-monomer' RNAs derived from the complementary strand of tobacco ringspot virus satellite RNA
    • (1993) Nucl. Acids Res. , vol.21 , pp. 1991-1998
    • Feldstein, P.A.1    Bruening, G.2
  • 35
    • 0031194873 scopus 로고    scopus 로고
    • A unique mechanism for RNA catalysis: The role of metal cofactors in hairpin ribozyme cleavage
    • (1997) Chem. Biol. , vol.4 , pp. 513-517
    • Hampel, A.1    Cowan, J.A.2
  • 39
    • 0024448572 scopus 로고
    • Sequences required for self-catalyzed cleavage of the satellite RNA of tobacco ringspot virus
    • (1989) Gene , vol.82 , pp. 43-52
    • Haseloff, J.1    Gerlach, W.L.2
  • 57
    • 0025186515 scopus 로고
    • Mutations affecting primer RNA interaction with the replication repressor RNA I in plasmid CoIE1: Potential RNA folding pathway mutants
    • (1990) EMBO J. , vol.9 , pp. 295-304
    • Polisky, B.1    Zhang, X.Y.2    Fitzwater, T.3
  • 62
    • 0032808217 scopus 로고    scopus 로고
    • Nucleotide analog interference mapping of the hairpin ribozyme: Implications for secondary and tertiary structure formation
    • (1999) J. Mol. Biol. , vol.291 , pp. 295-311
    • Ryder, S.P.1    Strobel, S.A.2
  • 65
    • 0032079494 scopus 로고    scopus 로고
    • A ribosomal function is necessary for efficient splicing of the T4 phage thymidylate synthase intron in vivo
    • (1998) Genes Dev. , vol.12 , pp. 1327-1337
    • Semrad, K.1    Schroeder, R.2
  • 70
    • 0024669291 scopus 로고
    • A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae
    • (1989) Genetics , vol.122 , pp. 19-27
    • Sikorski, R.S.1    Hieter, P.2
  • 73
    • 0033065715 scopus 로고    scopus 로고
    • The influence of junction conformation on RNA cleavage by the hairpin ribozyme in its natural junction form
    • (1999) RNA , vol.5 , pp. 180-187
    • Thomson, J.B.1    Lilley, D.M.J.2
  • 76
    • 0030969442 scopus 로고    scopus 로고
    • Real-time monitoring of hairpin ribozyme kinetics through base-specific quenching of fluorescein-labeled substrates
    • (1997) RNA , vol.3 , pp. 392-404
    • Walter, N.G.1    Burke, J.M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.