Structural basis for heterogeneous kinetics: Reengineering the hairpin ribozyme

Proceedings of the National Academy of Sciences of the United States of America

Volumn 95, Issue 11, 1998, Pages 6091-6096

  Esteban, Jose A ^a,c   Walter, Nils G ^a   Kotzorek, Gerd ^a,b   Heckman, Joyce E ^a   Burke, John M ^a  

^a UNIVERSITY OF VERMONT COLLEGE OF MEDICINE   (United States)

^b Kompostwerk Göttingen GmbH   (Germany)

^c Howard Hughes Medical Institute Cold Spring Harbor Laboratory Cold Spring Harbor   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RIBOZYME; RNA LIGASE;

ARTICLE; PRIORITY JOURNAL; REACTION ANALYSIS; RNA CLEAVAGE; RNA CONFORMATION;

GENETIC ENGINEERING; KINETICS; NUCLEIC ACID CONFORMATION; RNA, CATALYTIC; SUBSTRATE SPECIFICITY;

EID: 0032568597     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.95.11.6091     Document Type: Article

References (28)

1. D'Orval, B. C., Carafa, Y. D., Sirand-Pugnet, P., Gallego, M., Brody, E. & Marie, J. (1991) Science 252, 1823-1828.
2. Libri, D., Piseri, A. & Fiszman, M. Y. (1991) Science 252, 1842-1845.
3. Eng, F. J. & Warner, J. R., (1991) Cell 65, 797-804.
4. Dammel, C. S. & Noller, H. F. (1993) Genes Dev. 7, 660-670.
5. Fortner, D. M., Troy, R. G. & Brow, D. A. (1994) Genes Dev. 8, 221-233.
6. Herschlag, D. (1995) J. Biol. Chem. 270, 20871-20874.
7. Prody, G. A., Bakos, J. T., Buzayan, J. M., Schneider, I. R. & Bruening, G. (1986) Science 231, 1577-1580.
8. Buzayan, J. M., Gerlach, W. L. & Bruening, G. (1986) Nature (London) 323, 349-353.
9. Haseloff, J. & Gerlach, W. L. (1989) Gene 82, 43-52.
10. Feldstein, P. A., Buzayan, J. M. & Bruening, G. (1989) Gene 82, 53-61.
11. Hampel, A. & Tritz, R. (1989) Biochemistry 28, 4929-4933.
12. Hegg, L. A. & Fedor, M. J. (1995) Biochemistry 34, 15813-15828.
13. Esteban, J. A., Banerjee, A. R. & Burke, J. M. (1997) J. Biol. Chem. 272, 13629-13639.
14. Burke, J. M. (1994) Nucleic Acids Mol. Biol. 8, 105-118.
15. Burke, J. M., Butcher, S. E. & Sargueil, B. (1996) Nucleic Acids Mol. Biol. 10, 129-143.
16. Butcher, S. E., Heckman, J. E. & Burke, J. M. (1995) J. Biol. Chem. 270, 29648-29651.
17. Feldstein, P. A. & Bruening, G. (1993) Nucleic Acids Res. 21, 1991-1998.
18. Komatsu, Y., Koizumi, M., Nakamura, H. & Ohtsuka, E. (1994) J. Am. Chem. Soc. 116, 3692-3696.
19. Milligan, J. F. & Uhlenbeck, O. C. (1989) Methods Enzymol. 180, 51-62.
20. Sargueil, B., Pecchia, D. B. & Burke, J. M. (1995) Biochemistry 34, 7739-7748.
21. Chowrira, B. M. & Burke, J. M. (1992) Nucleic Acids Res. 20, 2835-2840.
22. Butcher, S. E. & Burke, J. M. (1994) Biochemistry 33, 992-999.
23. Uhlenbeck, O. C. & Oumport, R. I. (1982) The Enzymes XV, 31-58.
24. Moore, J. M. & Sharp, P. A. (1992) Science 256, 992-997
25. Mills, J. B., Cooper, J. P. & Hagerman, P. J. (1994) Biochemistry 33, 1797-1803.
26. Cate, J. H., Gooding, A. R., Podell, E., Zhou, K., Golden, B. L., Kundrot, C. E., Cech, T. R. & Doudna, J. A. (1996) Science 273, 1678-1685.
27. Cate, J. H., Gooding, A. R., Podell, E., Zhou, K., Golden, B. L., Szewczak, A. A., Kundrot, C. E., Cech, T. R. & Doudna, J. A. (1996) Science 273, 1696-1699.
28. Earnshaw, D. J., Masquida, B., Müller, S., Sigurdsson, S. T., Eckstein, F., Westhof, E. & Gait, M. J. (1997) J. Mol. Biol. 274, 197-212.