Multiple genetic alterations cause frequent and heterogeneous human histocompatibility leukocyte antigen class I loss in cervical cancer

Journal of Experimental Medicine

Volumn 191, Issue 6, 2000, Pages 961-975

  Koopman, Louise A ^a   Corver, Willem E ^a   Van Der Slik, Arno R ^a   Giphart, Marius J ^a   Fleuren, Gert Jan ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Cervix neoplasms immunology; DNA, neoplasm genetics; Genes, MHC class I; Loss of heterozygosity; Mutation

Indexed keywords

BETA 2 MICROGLOBULIN; HLA A ANTIGEN; HLA ANTIGEN CLASS 1; HLA B ANTIGEN;

ARTICLE; CONTROLLED STUDY; FEMALE; GENE MUTATION; GENETIC ANALYSIS; GENOTYPE; HAPLOTYPE; HETEROZYGOSITY LOSS; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; TUMOR IMMUNITY; UTERINE CERVIX CANCER;

ADENOCARCINOMA; CARCINOMA, SQUAMOUS CELL; CHROMOSOMES, HUMAN, PAIR 6; DNA MUTATIONAL ANALYSIS; FEMALE; FLOW CYTOMETRY; GENE DELETION; GENOTYPE; HAPLOTYPES; HLA-A ANTIGENS; HLA-B ANTIGENS; HUMANS; IMMUNOHISTOCHEMISTRY; MICROSATELLITE REPEATS; PHENOTYPE; POLYMERASE CHAIN REACTION; UTERINE CERVICAL NEOPLASMS;

EID: 0034689060     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.191.6.961     Document Type: Article

References (59)

1. The multistep nature of cancer
2. Implications for immunosurveillance of altered HLA class I phenotypes in human tumours
3. HLA class I antigens in human tumors
4. Frequency of down-regulation of individual HLA-A and -B alleles in cervical carcinomas in relation to TAP-1 expression
5. High frequency of altered HLA class I phenotypes in invasive breast carcinomas
6. High frequency of altered HLA class I phenotypes in invasive colorectal carcinomas
7. HLA and cancer: 12th International Histocompatibility Workshop Study
8. Loss of HLA haplotype and B locus down-regulation in melanoma cell lines
9. Loss of HLA class I antigens by melanoma cells: Molecular mechanisms, functional significance and clinical relevance
10. Mechanisms of loss of HLA class I expression on colorectal tumor cells
11. Loss of an HLA haplotype m pancreas cancer tissue and its corresponding tumor derived cell line
12. Tumor escape from immune recognition: Loss of HLA-A2 melanoma cell surface expression is associated with a complex rearrangement of the short arm of chromosome 6
13. Molecular analysis of the HLA-A2 antigen loss by melanoma cells SK-MEL-29.1.22 and SK-MEL-29.1.29
14. 2-Microglobulin mutations, HLA class I antigen loss, and tumor progression in melanoma
15. Selective histocompatibility leukocyte autigen (HLA)-A2 loss caused by aberrant pre-mRNA splicing in 624MEL28 melanoma cells
16. HLA-B downregulation in human melanoma is mediated by sequences located downstream of the transcription initiation site
17. Beta 2-microglobulin gene is mutated in a human colon cancer cell line (HCT) deficient in the expression of HLA class I antigens on the cell surface
18. A new beta2-microglobulin mutation found in a melanoma tumor cell line
19. HLA class I phenotype and genotype alterations in cervical carcinomas and derivative cell lines
20. Human leukocyte antigen class I gene mutations in cervical cancer
21. Immunogenetic factors in HPV-associated cervical cancer: Influence on disease progression
22. Association of allele-specific HLA expression and histopathologic progression of cervical carcinoma
23. Specific HLA class I down-regulation is an early event in cervical dysplasia associated with clinical progression
24. Human papillomavirus vaccines for cervical cancer
25. Allelic loss and prognosis in carcinoma of the uterine cervix
26. Genomic alterations in cervical carcinoma: Losses of chromosome heterozygosity and human papilloma virus tumor status
27. Allelotyping of all chromosomal arms in invasive cervical cancer
28. High resolution mapping of chromosome 6 deletions in cervical cancer
29. Different profiles of allelic losses in cervical carcinoma cases in Surinam and The Netherlands
30. Recurrent integration of human papillomaviruses 16, 45, and 67 near translocation breakpoints in new cervical cancer cell lines
31. A four-color multiparameter DNA flow cytometric method to study phenotypic intra-tumor heterogeneity in cervical cancer
32. Microsatellites in the HLA region: An overview
33. Microsatellites in the HLA region: 1998 update
34. Chromosome loss is the most frequent mechanism contributing to HLA haplotype loss in human tumors
35. Allelotype analysis of cervical carcinoma
36. Instability of chromosome 6 microsatellite repeats in human cervical tumors carrying papillomavirus sequences
37. Stable inheritance of an HLA-'blank' phenotype associated with a structural mutation in the HLA-A*0301 gene
38. Natural inactivation of a common HLA allele (A*2402) has occurred on at least three separate occasions
39. An HLA-B null allele (B*1526N) with a stop codon in exon 3 generated by a point mutation
40. Mutations of the beta2-microglobulin gene result in a lack of HLA class I molecules on melanoma cells of two patients immunized with MAGE peptides
41. Structural and functional analysis of beta2 microglobulin abnormalities in human lung and breast cancer
42. 2-Microgloblin gene mutations in human melanoma cells; molecular characterization and implications for immune surveillance
43. Beta 2-microglobulin gene mutations: A study of established colorectal cell lines and fresh tumors
44. Loss of MHC class-I expression in cervical carcinomas
45. Loss of transporter protein, encoded by the TAP-1 gene, is highly correlated with loss of HLA expression in cervical carcinoma
46. The Expression of histocompatibility-related leukocyte antigens in the pathway to cervical carcinoma
47. In vivo and in vitro generation of a new altered HLA phenotype in melanoma-turnout-cell variants expressing a single HLA-class-I allele
48. TAP off - Tumors on
49. Analysis of MHC class I and II expression in relation to presence of HPV genotypes in pre-malignant and malignant cervical lesions
50. Genetic alterations during the progression of squamous cell carcinomas of the uterine cervix
51. Cervical intraepithelial neoplasia III shows frequent allelic loss in 3p and 6p
52. Immune selection after antigen-specific immunotherapy of melanoma
53. Tumor regressions observed in patients with metastatic melanoma treated with an antigenic peptide encoded by gene MAGE-3 and presented by HLA-A1
54. Vaccination with HPV16 peptides of patients with advanced cervical carcinoma: Clinical evaluation of a phase I-II trial
55. Antitumor immunity at work in a melanoma patient
56. Simultaneous measurement of two cellular antigens and DNA using fluorescein-isothiocyanate, R-phycoerythrin, and propidium iodide on a standard FACScan(TM)
57. One-tube triple staining method for flow cytometric analysis of DNA ploidy and phenotypic heterogeneity of human solid tumors using single laser excitation
58. Nucleotide sequences of MHC class I introns 1, 2, and 3 in humans and intron 2 in nonhuman primates
59. HLA class I region sequences