Role of hydrophobic interactions in binding S-(N-aryl/alkyl-N-hydroxycarbamoyl)glutathiones to the active site of the antitumor target enzyme glyoxalase I

Journal of Medicinal Chemistry

Volumn 43, Issue 21, 2000, Pages 3981-3986

  Kalsi, A ^a   Kavarana, M J ^a   Lu, T ^a   Whalen, D L ^a   Hamilton, D S ^a   Creighton, D J ^a  

^a UNIVERSITY OF MARYLAND BALTIMORE COUNTY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; ENZYME INHIBITOR; GLUTATHIONE DERIVATIVE; LACTOYLGLUTATHIONE LYASE; S (N HYDROXYCARBAMOYL)GLUTATHIONE; UNCLASSIFIED DRUG;

ARTICLE; DRUG PROTEIN BINDING; DRUG STRUCTURE; ENERGY; ENZYME ACTIVE SITE; HUMAN; HYDROPHOBICITY; NONHUMAN; PSEUDOMONAS PUTIDA; X RAY CRYSTALLOGRAPHY; YEAST;

ANTINEOPLASTIC AGENTS; CARBAMATES; CATALYTIC DOMAIN; ENZYME INHIBITORS; GLUTATHIONE; LACTOYLGLUTATHIONE LYASE; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PROTEIN BINDING; STEREOISOMERISM;

EID: 0034687245     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm000160l     Document Type: Article

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