Mechanism-based competitive inhibitors of glyoxalase I: Intracellular delivery, in vitro antitumor activities, and stabilities in human serum and mouse serum

Journal of Medicinal Chemistry

Volumn 42, Issue 2, 1999, Pages 221-228

  Kavarana, Malcolm J ^a   Kovaleva, Elena G ^a   Creighton, Donald J ^a   Wollman, Megan B ^b   Eiseman, Julie L ^b,c  

^a UNIVERSITY OF MARYLAND BALTIMORE COUNTY   (United States)

^b UNIVERSITY OF MARYLAND GREENEBAUM CANCER CENTER   (United States)

^c UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; HYDROXYACYLGLUTATHIONE HYDROLASE; LACTOYLGLUTATHIONE LYASE; LACTOYLGLUTATHIONE LYASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CELL MEMBRANE PERMEABILITY; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG STABILITY; DRUG STRUCTURE; ENZYME INHIBITION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; SERUM; SPLEEN CELL;

ANIMALS; ANTINEOPLASTIC AGENTS; BINDING, COMPETITIVE; CELL DIVISION; CELL MEMBRANE PERMEABILITY; CELLS, CULTURED; DRUG STABILITY; ENZYME INHIBITORS; HUMANS; LACTOYLGLUTATHIONE LYASE; MICE; TUMOR CELLS, CULTURED;

EID: 0032907791     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9708036     Document Type: Article

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