Alteration at a single amino acid residue in the T cell receptor α chain complementarity determining region 2 changes the differentiation of naive CD4 T cells in response to antigen from T helper cell type 1 (Th1) to Th2

Journal of Experimental Medicine

Volumn 191, Issue 12, 2000, Pages 2065-2073

  Blander, J Magarian ^a   Sant'Angelo, Derek B ^b   Bottomly, Kim ^a   Janeway Jr , Charles A ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Weill Cornell Medical Center   (United States)

Author keywords

Interferon type II; Interleukin 4; Mice; Peptides; Transgenic

Indexed keywords

INTERLEUKIN 4; LEUCINE; SERINE; T LYMPHOCYTE RECEPTOR ALPHA CHAIN;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE PROLIFERATION; MOLECULAR RECOGNITION; MOUSE; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE; TRANSGENIC MOUSE;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; GENES, T-CELL RECEPTOR ALPHA; IMMUNITY, CELLULAR; INTERFERON TYPE II; INTERLEUKIN-4; MAJOR HISTOCOMPATIBILITY COMPLEX; MICE; MICE, MUTANT STRAINS; MICE, TRANSGENIC; MUTATION; PEPTIDES; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; TH1 CELLS; TH2 CELLS;

EID: 0034686578     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.191.12.2065     Document Type: Article

References (37)

1. Germain, R.N. 1994. Major histocompatibility complex-dependent antigen processing and peptide presentation: providing ligands for the clonal activation of T lymphocytes. Cell. 76:287-299.
2. Janeway, C.A., Jr., and K. Bottomly. 1994. Signals and signs for lymphocyte responses. Cell. 76:275-285.
3. Mosmann, T.R., H. Cherwinski, M.W. Bond, M.A. Giedlin, and R.L. Coffman. 1986. Two types of murine helper T cell clones. I. Definition according to profiles of lymphokine activities and secreted proteins. J. Immunol. 136:2348-2357.
4. Abbas, A.K., and K.M. Murphy. 1996. Functional diversity of helper T lymphocytes. Nature. 383:787-793.
5. - T cell responses: the alternative approaches. Annu. Rev. Immunol. 15:297-322.
6. + T cells in Th2 response and immunoglobulin E production. Science. 270:1845-1847.
7. + T cells. J. Exp. Med. 185:461-469.
8. Trinchieri, G. 1997. Cytokines acting on or secreted by macrophages during intracellular infection (IL-10, IL-12, IFN-γ). Curr. Opin. Immunol. 9:17-23.
9. Janeway, C.A., Jr. 1998. Presidential Address to The American Association of Immunologists. The road less traveled by: the role of innate immunity in the adaptive immune response. J. Immunol. 161:539-544.
10. Fearon, D.T., and R.M. Locksley. 1996. The instructive role of innate immunity in the acquired immune response. Science. 272:50-54.
11. Davis, M.M., J.J. Boniface, Z. Reich, D. Lyons, J. Hampl, B. Arden, and Y. Chien. 1998. Ligand recognition by alpha beta T cell receptors. Annu. Rev. Immunol. 16:523-544.
12. Bjorkman, P.J., M.A. Saper, B. Samraoui, W.S. Bennett, J.L. Strominger, and D.C. Wiley. 1987. Structure of the human class I histocompatibility antigen HLA-A2. Nature. 329:506-512.
13. Stern, L.J., J.H. Brown, T.S. Jardetsky, J.C. Gorga, R.G. Urban, J.L. Strominger, and D.C. Wiley. 1994. Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide. Nature. 368:215-221.
14. Stern, L.J., and D.C. Wiley. 1994. Antigenic peptide binding by class I and class II histocompatibility proteins. Structure. 2:245-251.
15. Sant'Angelo, D.B., G. Waterbury, P. Preston-Hurlburt, S.T. Yoon, R. Medzhitov, S.-C. Hong, and C.A. Janeway, Jr. 1996. The specificity and orientation of a TCR to its peptide-MHC class II ligands. Immunity. 4:367-376.
16. Hong, S.-C., A. Chelouche, R.-H. Lin, D. Shaywitz, N.S. Braunstein, L. Glimcher, and C.A. Janeway, Jr. 1992. An MHC interaction site maps to the amino-terminal half of the T cell receptor α chain variable domain. Cell. 69:1-20.
17. Jorgensen, J.L., U. Esser, B. Fazekas de St. Groth, P.A. Reay, and M.M. Davis. 1992. Mapping T cell receptor-peptide contacts by variant peptide immunization of single-chain transgenics. Nature. 355:224-230.
18. d restricted cloned CTL specific for a photoreactive peptide derivative. Immunity. 3:51-63.
19. Danska, J.S., A.M. Livingstone, V. Paragas, T. Ishihara, and C.G. Fathman. 1990. The presumptive CDR3 regions of both T cell receptor alpha and beta chains determine T cell specificity for myoglobin peptides. J. Exp. Med. 172:27-33.
20. Garcia, K.C., M. Degano, R.L. Stanfield, A. Brunmark, M.R. Jackson, P.A. Peterson, L. Teyton, and I.A. Wilson. 1996. An alphabeta T cell receptor structure at 2.5 Å and its orientation in the TCR-MHC complex. Science. 274:209-219.
21. Garboczi, D.N., P. Ghosh, U. Utz, Q.R. Fan, W.E. Biddison, and D.C. Wiley. 1996. Structure of the complex between human T-cell receptor, viral peptide, and HLA-A2. Nature. 384:134-141.
22. Sloan-Lancaster, J., and P.M. Allen. 1996. Altered peptide ligand-induced partial T cell activation: molecular mechanisms and role in T cell biology. Annu. Rev. Immunol. 14:1-27.
23. Evavold, B.D., and P.M. Allen. 1991. Separation of IL-4 production from Th cell proliferation by an altered T cell receptor ligand. Science. 252:1308-1310.
24. Evavold, B.D., J. Sloan-Lancaster, B.L. Hsu, and P.M. Allen. 1993. Separation of T helper 1 clone cytolysis from proliferation and lymphokine production using analog peptides. J. Immunol. 150:3131-3140.
25. Pfeiffer, C., J. Murray, J. Madri, and K. Bottomly. 1991. Selective activation of Th1- and Th2-like cells in vivo - response to human collagen IV. Immunol. Rev. 123:65-84.
26. Pfeiffer, C., J. Stein, S. Southwood, H. Ketelaar, A. Sette, and K. Bottomly. 1995. Altered peptide ligands can control CD4 T lymphocyte differentiation in vivo. J. Exp. Med. 181: 1569-1574.
27. + T cells. J. Exp. Med. 182:1591-1596.
28. + T cells into Th1 and Th2 subsets. J. Immunol. 159:5802-5809.
29. Hong, S.-C., D.B. Sant'Angelo, B.N. Dittel, R. Medzhitov, S.T. Yoon, G. Waterbury, and C.A. Janeway, Jr. 1997. The orientation of a T cell receptor to its MHC class II:peptide ligands. J. Immunol. 159:4395-4402.
30. Kaye, J., S. Porcelli, J. Tite, B. Jones, and C.A. Janeway, Jr. 1983. Both a monoclonal antibody and antisera specific for determinants unique to individual cloned helper T cell lines can substitute for antigen and antigen presenting cells in the activation of T cells. J. Exp. Med. 158:836-856.
31. Janeway, C.A., Jr., and K. Bottomly. 1996. Responses of T cells to ligands for the T-cell receptor. Semin. Immunol. 8:109-115.
32. Dittel, B.N., D.B. Sant'Angelo, and C.A. Janeway, Jr. 1997. Peptide antagonists inhibit proliferation and the production of IL-4 and/or IFN-γ in T helper 1, T helper 2, and T helper 0 clones bearing the same TCR. J. Immunol. 158: 4065-4073.
33. Swain, S.L., M. Croft, C. Dubey, L. Haynes, P. Rogers, X. Zhang, and L.M. Bradley. 1996. From naive to memory T cells. Immunol. Rev. 150:143-167.
34. Sloan-Lancaster, J., and P.M. Allen. 1995. Significance of T-cell stimulation by altered peptide ligands in T cell biology. Curr. Biol. 7:103-109.
35. + T cells by antigenic peptides altered for TCR binding. J. Immunol. 158:4327-4344.
36. Ding, Y.-H., B.M. Baker, D.N. Garboczi, W.E. Biddison, and D.C. Wiley. 1999. Four A6-TCR/peptide/HLA-A2 structures that generate very different T cell signals are nearly identical. Immunity. 11:45-56.
37. Reinherz, E.L., K. Tan, L. Tang, P. Kern, J. Liu, Y. Xiong, R.E. Hussey, A. Smolyar, B. Hare, R. Zhang, et al. 1999. The crystal structure of a T cell receptor in complex with a peptide and MHC class II. Science. 286:1913-1921.