Asymmetric cell division and neurogenesis

Current Opinion in Genetics and Development

Volumn 6, Issue 5, 1996, Pages 562-566

  Doe, Chris Q ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL DIVISION; CELL POLARITY; DROSOPHILA; NERVOUS SYSTEM DEVELOPMENT; NEUROBLAST; PRIORITY JOURNAL; SHORT SURVEY; VERTEBRATE;

VERTEBRATA;

EID: 0030272589     PISSN: 0959437X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-437X(96)80084-0     Document Type: Article

References (27)

1. Schagat T, Lin H. Neuroblasts: a model for the asymmetric division of stem cells. of outstanding interest Trends Genet. 1996; An excellent recent review, covering Prospero, Numb and Inscuteable localization in neuroblasts and comparing asymmetric divisions in the Drosophila nervous system, vertebrate neurogenesis, and Drosophila oogenesis.
2. Doe CQ, Spana EP. A collection of cortical crescents: asymmetric protein localization in CNS precursor cells. Neuron. 15:1995;991-995.
3. Rhyu MS, Knoblich JA. Spindle orientation and asymmetric cell fate. Cell. 82:1995;523-526.
4. Knust E. Control of epithelial cell polarity in Drosophila. Trends Genet. 10:1994;275-280.
5. Spana E, Doe CQ. The prospero transcription factor is asymmetrically localized to the cell cortex during neuroblast mitosis in Drosophila. of outstanding interest Development. 121:1995;3187-3195 See annotation [15].
6. Goodman CS, Doe CO. Embryonic development of the Drosophila central nervous system. The Development of Drosophila melanogaster. 2:1993;1131-1206 Cold Spring Harbor Laboratory Press, New York.
7. Campos-Ortega JA, Hartenstein V. The Embryonic Development of Drosophila melanogaster. 1985;Springer-Verlag, Berlin.
8. Bate CM, Grunewald EB. Embryogenesis of an insect nervous system. II. A second class of neuron precursor cells and the origin of the intersegmental connectives. J Embryol Exp Morph. 61:1981;317-330.
9. Spana EP, Kopczynski C, Goodman CS, Doe CO. Asymmetric localization of numb autonomously determines sibling neuron identity in the Drosophila CNS. of outstanding interest Development. 121:1995;3489-3494 The expression and function of Numb in simple MP2 lineage is described. Numb is localized asymmetrically at MP2 division into the basal dMP2 sibling and excluded from the apical vMP2 sibling. Numb is necessary and sufficient to specify the dMP2 neuron fate.
10. Kraut R, Campos-Ortega JA. inscuteable, a neural precursor gene of Drosophila, encodes a candidate for a cytoskeleton adaptor protein. of outstanding interest Dev Biol. 174:1996;65-81 This paper reports the cloning of inscuteable (as well as the RNA and protein expression patterns) and the mutant phenotype in the embryo and adult. Inscuteable protein is localized to the apical cortex of determinating and mature neuroblasts, and is required for normal CNS development. More recent work has shown that Inscuteable is required for spindle orientation and Prospero/Numb localization in neuroblasts (R Kraut, W Chia, YN Jan, J Knobilich, personal communication).
11. Knoblich JA, Jan LY, Jan YN. Asymmetric segregation of Numb and Propero during cell division. of outstanding interest Nature. 377:1995;624-627 See annotation [15].
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13. Chu-LaGraff Q, Wright DM, McNeil LK, Doe CQ. The prospero gene encodes a divergent homeodomain protein that controls neuronal identity in Drosophila. Development. 2:1991;79-85. Suppl.
14. Vaessin H, Grell E, Wolff E, Bier E, Jan LY, Jan YN. prospero is expressed in neuronal precursors and encodes a nuclear protein that is involved in the control of axonal outgrowth in Drosophila. Cell. 67:1991;941-953.
15. Hirata J, Nakagoshi H, Nabeshima Y, Matsuzaki F. Asymmetric segregation of a homeoprotein, prospero, during cell divisions in neural and endodermal development. of outstanding interest Nature. 377:1995;627-630 References [5, 13, 14, 15] show that neuroblasts, SOPs, and gut precursors have a novel mechanism for asymmetric localization of Pros and Numb. Localization requires entry into mitosis but not microtubules or microfilaments.
16. Rhyu MS, Jan LY, Jan YN. Asymmetric distribution of numb protein during division of the sensory organ precursor cell confers distinct fates to daughter cell. Cell. 76:1994;477-491.
17. Uemura T, Sheperd S, Ackerman L, Jan LY, Jan YN. numb, a gene required in determination of cell fate during sensory organ formation in Drosophila embryos. Cell. 58:1989;349-360.
18. St Johnston D. The intracellular localization of messenger RNAs. Cell. 81:1995;161-180.
19. Rongo C, Lehmann R. Regulated synthesis, transport, and assembly of the Drosophila germ plasm. Trends Genet. 12:1996;102-109.
20. White J, Strome S. Cleavage plane specification in C. elegans: how to divide the spoils. Cell. 84:1996;195-198.
21. Guo M, Jan LY, Jan YN. Control of daughter cell fates during asymmetric division: interaction of the cell intrinsic determinant Numb and the Notch receptor for cell-cell communication. of outstanding interest Neuron. 17:1996;24-41 Here, the authors show that numb is epistatic to Notch in the external sense organ lineage, suggesting the Numb antagonizes Notch function. In vitro assays indicate that Numb and Notch interact directly.
22. Spana EP, Doe CQ. Numb antagonizes Notch signaling to specify sibling neuron cell fates. of outstanding interest Neuron. 17:1996;21-26 Shows that numb is epistatic to Notch and Delta in the MP2 lineage, suggesting that Numb antagonizes Notch function. In vivo antibody staining and in vitro culture assays indicate that the Delta signal comes from outside the MP2 lineage.
23. Parks AL, Muskavitch MA. Delta function is required for bristle organ determination and morphogenesis in Drosophila. Dev Biol. 157:1993;484-496.
24. Hartenstein V, Posakony JW. A dual function of the Notch gene in Drosophila sensillum development. Dev Biol. 142:1990;13-30.
25. Chenn A, McConell SK. Cleavage orientation and the asymmetric inheritance of Notch1 immunoreactivity in mammalian neurogenesis. of outstanding interest Cell. 82:1995;631-641 Provides the first evidence for asymmetric division of ventricular zone precursors in the vertebrate cerebral cortex by Dil labeling. Also shows asymmetric localization of Notch1 in basal crescents in dividing ventricular zone precursors.
26. Zhong W, Feder JN, Jiang M-M, Jan LY, Jan YN. Asymmetric localization of a mammalian Numb homologue during mouse cortical neurogenesis. of outstanding interest Neuron. 1996;
27. Kraut R, Chia W, Jan LY, Jan YN, Knoblich JA. Role of Inscuteable in orienting asymmetric cell divisions in Drosophila. Nature. 382:1996;50-55.