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For example, the so-called ionophorous antibiotics, (e.g., Nonactin, Monactin, and Dinactin), which hind to cations and are closely related to crown ethers, could, in theory, be incorporated into rotaxane-like complexes. See: (a) Kilbourn, B. T.; Dunnitz, J. D., Pioda, L. A.; Simon, W. J. Mol. Biol. 1967, 30, 559-563.
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37049125686
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The "slippage" methodology was first exploited for rotaxane syntheses that were conducted in a statistical manner. In the absence of mutual recognition interactions between the ring and thread, formation of a rotaxanelike complex relied simply upon chance encounters between the components. For examples, see: (a) Harrison, I. T. J. Chem. Soc., Chem. Commun. 1972, 231-232.
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0033531989
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Ashton, P. R.; Bartsch, R. A.; Cantrill, S. J.; Hanes, R. E., Jr.; Hickingbottom, S. K.; Lowe, J. N.; Preece, J. A.; Stoddart, J. F.; Talanov, V. S.; Wang, Z.-H. Tetrahedron Lett. 1999, 40, 3661-3664.
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Talanov, V.S.9
Wang, Z.-H.10
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31
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85037516027
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note
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3CN) were collected in the early stages of the experiment where the "slipping-on" process is not yet occurring to any significant extent.
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-
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32
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85037508013
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See Table 1, footnote d
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See Table 1, footnote d.
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