Synthesis, 18F-labeling, and biological evaluation of piperidyl and pyrrolidyl benzilates as in vivo ligands for muscarinic acetylcholine receptors

Journal of Medicinal Chemistry

Volumn 43, Issue 23, 2000, Pages 4552-4562

  Skaddan, M B ^a   Kilbourn, M R ^a   Snyder, S E ^a   Sherman, P S ^a   Desmond, T J ^a   Frey, K A ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENZILIC ACID; FLUORINE 18; MUSCARINIC RECEPTOR; PIPERIDINE; PYRROLIDINE DERIVATIVE;

ALKYLATION; ARTICLE; CHEMICAL ANALYSIS; ENZYME ACTIVITY; IN VIVO STUDY; ISOTOPE LABELING; LEARNING; LIGAND BINDING; MEMORY; POSITRON EMISSION TOMOGRAPHY; RECEPTOR BINDING; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; SYNTHESIS;

ACETYLCHOLINE; ANIMALS; BENZILATES; BENZYL COMPOUNDS; BRAIN; FEMALE; FLUORINE RADIOISOTOPES; ISOTOPE LABELING; LIGANDS; MICE; PIPERIDINES; PYRROLIDINES; RADIOLIGAND ASSAY; RATS; RECEPTORS, MUSCARINIC; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP; TISSUE DISTRIBUTION;

EID: 0034676317     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm000305o     Document Type: Article

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