Using single photon emission tomography (SPECT) and positron emission tomography (PET) to trace the distribution of muscarinic acetylcholine receptor (MACHR) binding radioligands

Life Sciences

Volumn 64, Issue 6-7, 1999, Pages 511-518

  Kiesewetter, Dale O ^a   Carson, Richard E ^a   Jagoda, Elaine M ^a   Herscovitch, Peter ^a   Eckelman, William C ^a,b  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

mAChR binding radioligands; PET; SPECT

Indexed keywords

3 QUINUCLIDINYL 4 FLUOROMETHYLBENZILATE; 3 QUINUCLIDINYL 4 IODOBENZILATE; [3 (PROPYLTHIO) 1,2,5 THIADIAZOL 4 YL]TETRAHYDRO 1 METHYLPYRIDINE; FLUORINE 18; MUSCARINIC M2 RECEPTOR; MUSCARINIC RECEPTOR; QUINUCLIDINYL BENZILATE; RADIOLIGAND; THIADIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; BRAIN REGION; CONFERENCE PAPER; DRUG DISTRIBUTION; DRUG SCREENING; ISOTOPE LABELING; LIGAND BINDING; NONHUMAN; ORGAN PERFUSION; POSITRON EMISSION TOMOGRAPHY; RAT; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY;

ANIMALS; BENZILATES; BRAIN; FLUORINE RADIOISOTOPES; HEART; HUMANS; LIGANDS; MUSCARINIC AGONISTS; MUSCARINIC ANTAGONISTS; MYOCARDIUM; PHYSOSTIGMINE; PYRIDINES; QUINUCLIDINES; RADIOACTIVE TRACERS; RECEPTORS, MUSCARINIC; THIAZOLES; TOMOGRAPHY, EMISSION-COMPUTED; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON;

ANIMALIA; PRIMATES; RODENTIA;

EID: 0033534654     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0024-3205(98)00595-5     Document Type: Conference Paper

References (17)

1. W.C. Eckelman and R.E. Gibson.. Nuclear Imaging in Drug Discovery, Development and Approval (Ed. HD Burns, RE Gibson, RF Dannals and PKS Siegl). Birkhauser Boston, Inc. Boston MA. P 113-134 (1992).
2. J.T. Farrow, and R.D. O'Brien: Molecular Pharmacol 9 33-40 (1973).
3. H.I. Yamamura, H.S. Synder Life Sciences 71 1725-1729 (1974).
4. W.C. Eckelman, R.C. Reba, W.J. Rzeszotarski, R.E. Gibson, T. Hill, B.L. Holman, T. Budinger, J.J. Conklin, R. Eng, M. GrissoM. Science. 223 291-293 (1984).
5. D.R. Weinberger, R.E. Gibson, R. Cappola, D.W. Jones, S. Molchan, T. Sunderland, K.F. Berman, R.C. Reba Arch Neurol Med 20 379-386 (1991).
6. D.R. Weinberger, D. Jones, R.C. Reba, U. Mann, R. Coppola, R. Gibson, J. Gorey, A. Braun, T.N. Chase, J Neuropsychiatry Clin Neurosci 4 239-248 (1992).
7. Y. Sawada, S. Hiraga, B. Francis, C. Patlak, K. Pettigrew, K. Ito, E. Owens, R. Gibson, R.C. Reba, W.C. Eckelman, S. Larson, R. Blasberg J. Cereb. Blood Flow Metabol. 10 781-807 (1990).
8. J.T. Lee, C.H. Paik, D.O. Kiesewetter, S.G. Park, W.C. Eckelman. Nucl Med Biol 22 773-382 (1995)
9. D.O. Kiesewetter, R.E. Carson, E.M. Jagoda, C.J. Endres, M.G. Der, P. Herscovitch, W.C. Eckelman. Bioorganic & Medicinal Chemistry 5 1555-1567 (1997).
10. R.C. McRee, S.F. Boulay, V.K. Sood, E.I. Cohen, V.I. Cohen, M.S. Gitler, B.R. Zeeberg, R.E. Gibson, R.C. Reba, Neuroimaging 2 55-62 (1995).
11. Sauerberg P, Olesen P, Nielsen, S. Treppendahl, M.J. Sheardown, T. Honore, C.H., Mitch, J.S. Ward. A.J. Pike, F.P. Bymaster, J Med Chem 35 2274-2283 (1992).
12. D.O. Kiesewetter, J.T. Lee, S.G. Park, C.H. Paik, W.C. Eckelman. J Med Chem 38 5-8 (1995).
13. D.O. Kiesewetter, R.E. Carson, E. Jagoda, P. Herscovitch, C.H. Paik and W.C. Eckelman, Synapse (1998).
14. N.A. Lassen and W. Perl, Tracer Kinetic Methods in Medical Physiology. Raven Press, New York, NY (1979).
15. P. Herscovitch, Principles of Nuclear Medicine, 2nd Ed, Wagner HN Jr et al, (eds), W.B. Saunders, 505-514 (1995).
16. P. Herscovitch, Principles of Nuclear Medicine, 2nd Ed, Wagner HN Jr et al, (eds), W.B. Saunders, 514-531 (1995).
17. R.E. Carson, D.O. Kiesewetter, E. Jagoda, M.G. Der, P. Herscovitch, W.C. Eckelman, J Cereb Blood Flow Metab, 18:1130-1142, 1998.