Muscarinic cholinergic receptor measurements with [18F]FP-TZTP: Control and competition studies

Journal of Cerebral Blood Flow and Metabolism

Volumn 18, Issue 10, 1998, Pages 1130-1142

  Carson, Richard E ^a   Kiesewetter, Dale O ^a   Jagoda, Elaine ^a   Der, Margaret G ^a   Herscovitch, Peter ^a   Eckelman, William C ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

FP TZTP; Modeling; Muscarinic receptors; Physostigmine; Volume of distribution

Indexed keywords

3 [3 (3 FLUOROPROPYL)THIO] 1,2,5 THIADIAZOL 4 YL 1,2,5,6 TETRAHYDRO 1 METHYLPYRIDINE; BENZATROPINE; MUSCARINIC AGENT; MUSCARINIC RECEPTOR; PHYSOSTIGMINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BASAL GANGLION; BRAIN CORTEX; CONTROLLED STUDY; DRUG DISTRIBUTION; DRUG RECEPTOR BINDING; INTRAVENOUS DRUG ADMINISTRATION; ISOTOPE LABELING; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RHESUS MONKEY; THALAMUS;

ACETYLCHOLINE; ANESTHESIA; ANESTHETICS, INHALATION; ANIMALS; BINDING, COMPETITIVE; BLOOD PROTEINS; BRAIN; CHOLINESTERASE INHIBITORS; CHROMATOGRAPHY, THIN LAYER; FLUORINE RADIOISOTOPES; ISOFLURANE; KINETICS; MACACA MULATTA; MODELS, NEUROLOGICAL; PHYSOSTIGMINE; PYRIDINES; RECEPTORS, MUSCARINIC; THIAZOLES; TOMOGRAPHY, EMISSION-COMPUTED;

EID: 0031665902     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004647-199810000-00010     Document Type: Article

References (39)

1. Akaike H (1976) An information criterion (AIC). Math Sci 14:5-9
2. Aubert I, Araujo DM, Cecyre D, Robitaille Y, Gauthier S, Quirion R (1992) Comparative alterations of nicotinic and muscarinic binding sites in Alzheimer's and Parkinson's diseases. J Neurochem 58:529-541
3. Breier A, Su TP, Saunders R, Carson RE, Kolachana BS, de Bartolomeis A, Weinberger DR, Weisenfeld N, Malhotra AK, Eckelman WC, Pickar D (1997) Schizophrenia is associated with elevated amphetamine-induced synaptic dopamine concentrations: evidence from a novel positron emission tomography method. Proc Natl Acad Sci USA 94:2569-2574
4. 18F]-cyclofoxy and positron emission tomography. J Cereb Blood Flow Metab 13:24-42
5. 11C]raclopride binding with continuous infusion. J Cereb Blood Flow Metab 17:437-447
6. Cuadra G, Giacobini E (1995) Effects of cholinesterase inhibitors and clonidine coadministration on rat cortex neurotransmitters in vivo. J Pharmacol Exp Ther 275:228-236
7. DeGrado TR, Turkington T, Williams JJ, Hoffman JM, Coleman RE (1994) Performance characteristics of a whole-body PET scanner. J Nucl Med 35:1398-1406
8. Dewey SL, Volkow ND, Logan J, MacGregor RR, Fowler JS, Schlyer DJ, Bendriem B (1990) Age-related decreases in muscarinic cholinergic receptor binding in the human brain measured with positron emission tomography. J Neurosci Res 27:569-575
9. Durieux ME (1996) Muscarinic signaling in the central nervous system. Recent developments and anesthetic implications. Anesthesiology 84:173-189
10. Eckelman WC, Eng R, Rzeszotarski WJ, Gibson RE, Francis B, Reba RC (1985) Use of 3-quinuclidinyl 4-iodobenzylate as a receptor binding radiotracer. J Nucl Med 26:637-642
11. Elsayed NM, Ryabik JRG, Ferraris S, Wheeler CR, Korte DW (1989) Determination of physostigmine in plasma by high-performance liquid chromatography and fluorescence detection. Anal Biochem 177:207-211
12. 2-dopamine receptors studied by PET: a comparison to the equilibrium analysis. J Cereb Blood Flow Metab 9:696-708
13. 15C]butylthioTZTP in monkey and man. Dementia 7:187-195
14. 3H]-methylscopolamine afford differential labeling and localization of M1, M2, and M3 muscarinic receptor subtypes in primate brain. Synapse 14:283-293
15. Flynn DD, Ferrari-DiLeo G, Mash DC, Levey AI (1995) Differential regulation of molecular subtypes of muscarinic receptors in Alzheimer's disease. J Neurochem 64:1881-1891
16. 11C]scopolamine and positron emission tomography. J Cereb Blood Flow Merab 12:147-154
17. 15O. I. Theory and error analysis. J Nucl Med 24:782-789
18. 15O]water and dynamic positron emission tomography. J Cereb Blood Flow Metab 8:285-288
19. 18F-labeled muscarinic agonist with M2 selectivity. J Med Chem 38:5-8
20. Kiesewetter DO, Jagoda EM, Carson RE, Herscovitch P, Eckelman WC (1996) Biodistribution of muscarinic subtype selective agonists of the thiadiazoyl tetrahydropyridine class. J Nucl Med 37:351P
21. Kiesewetter DO, Carson RE, Jagoda EM, Herscovitch P, Eckelman WC (1998) In vivo muscarinic binding of 3-(alkylthio)-3-thiadiazoylyl tetrahydropyridines. Synapse (In press)
22. 11C]flumazenil kinetics for the estimation of ligand transport rate and receptor distribution using positron emission tomography. J Cereb Blood Flow Metab 11:735-744
23. 11C]Tropanyl benzilate binding to muscarinic cholinergic receptors: methodology and kinetic modeling alternatives. J Cereb Blood Flow Metab 14:85-99
24. Lammertsma AA, Bench CJ, Hume SP, Osman S, Gunn K, Brooks DJ, Frackowiak RSJ (1996) Comparison of methods for analysis of clinical [C-11] raclopride studies. J Cereb Blood Flow Metab 16: 42-52
25. Li M, Yasuda RP, Wall SJ, Wellstein A, Wolfe BB (1991) Distribution of m2 muscarinic receptors in rat brain using antisera selective for m2 receptors. Mol Pharmacol 40:28-35
26. 11C-methyl]-(-)-cocaine: PET studies in human subjects. J Cereb Blood Flow Metab 10:740-747
27. Maziere M (1995) Cholinergic neurotransmission studied in vivo using positron emission tomography or single photon emission computerized tomography. Pharmacol Ther 66:83-101
28. McPherson RW, Kirsch JR, Tobin JR, Ghaly RF, Traystman RJ (1994) Cerebral blood flow in primates is increased by isoflurane over time and is decreased by nitric oxide synthase inhibition. Anesthesiology 80:1320-1327
29. Messamore E, Warpman U, Ogane N, Giacobini E (1993) Cholinesterase inhibitor effects on extracellular acetylcholine in rat cortex. Neuropharmacologv 32:745-750
30. Mesulam M-M, Volicer L, Marquis JK, Mufson EJ, Green RC (1986) Systematic regional differences in the cholinergic innervation of the primate cerebral cortex: distribution of enzyme activities and some behavioral implications. Ann Neurol 19:144-151
31. Mulholland GK, Kilbourn MR, Sherman P, Carey JE, Frey KA, Koeppe RA, Kuhl DE (1995) Synthesis, in-vivo biodistribution and dosimetry of [C-11]n-methylpiperidyl benzilate ([C-11]NMPB), a muscarinic acetylcholine-receptor antagonist. Nucl Med Biol 22: 13-17
32. Sauerberg P, Olesen PH, Nielsen S, Treppendahl S, Sheardown MJ, Honore T, Mitch CH, Ward JS, Pike AJ, Bymaster FP, Sawyer BD, Shannon HE (1992) Novel functional M1 selective muscarinic agonists. Synthesis and structure-activity relationships of 3-(1,2,5-thiadiazoyl)-1,2,5,6-tetrahydro-1-methylpyridines. J Med Chem 35:2274-2283
33. Schliebs R, Robner S (1995) Distribution of muscarinic acetylcholine receptors in the CNS. In: CNS Neurotransmitters and Neuromodulators: Acetylcholine (Stone TW, ed), Boca Raton, FL, CRC Press, pp 67-83
34. Scremin OU, Scremin AM, Somani SM, Giacobini E (1990) Brain regional distribution of physostigmine and its relation to cerebral blood flow following intravenous administration in rats. J Neurosci Res 26:188-195
35. Stearns C (1995) Scatter correction method for 3D PET using 2D fitted Gaussian functions. J Nucl Med 36:205P
36. Strother SC, Casey ME, Hoffman EJ (1990) Measuring PET scanner sensitivity; relating count rates to image signal-to-noise ratios using noise equivalent counts. IEEE Trans Nucl Sci 37:783-788
37. Tavitian B, Pappata S, Planas AM, Jobert A, Bonnot-Lours S, Crouzel C, DiGiamberadino L (1993) In vivo visualization of acetylcholinesterase with positron emission tomography. Neuroreport 4: 535-538
38. 11C]physostigmine, a PET tracer for acetylcholinesterase. J Cereb Blood Flow Metab 15:S122
39. Wall SJ, Yasuda RP, Hory F, Flagg S, Martin BM, Ginns EI, Wolfe BB (1991) Production of antisera selective for m1 muscarinic receptors using fusion proteins: distribution of m1 receptors in rat brain. Mol Pharmacol 39:643-649