An improved synthesis of the strained pyrrolidine-5,5-translactam ring system

Tetrahedron Letters

Volumn 40, Issue 15, 1999, Pages 3061-3062

  Borthwick, Alan D ^a   Crame, Andy ^a   Exall, Anne ^a   Mason, Andy ^a   Pennell, Andy ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Lactamisation; Lactams; Pyrrolidines Pyrrolidinones; Strained compounds

Indexed keywords

ESTER DERIVATIVE; ETHYLAMINE; LACTAM DERIVATIVE; MAGNESIUM CHLORIDE; PYRROLE DERIVATIVE; PYRROLIDINE DERIVATIVE; TETRAHYDROFURAN;

ARTICLE; CHEMICAL REACTION; CYCLIZATION; STEREOSPECIFICITY; SYNTHESIS; TRANS ISOMER;

EID: 0033537819     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(99)00365-2     Document Type: Article

References (6)

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2. Dowle, M. D.; Finch, H.; Harrison, L. A.; Inglis, G. G. A.; Johnson, M. R.; MacDonald, S. J. F.; Shah, P.; Smith, R. A. PCT Int.Appl. No. WO 9736903 A1 971009P 1997.
3. Steliou, K.; Poupart, M. A J. Am. Chem. Soc., 1983, 105, 7130.
4. Ogliraruso, M. A.; Wolfe, J. F. In Synthesis of Lactones and Lactams, Patai, S.; Rappoport, Z.; Eds.; Chichester, New York, 1993, 135-137, 400-403.
5. Shono, T.; Tsubata, T.; Okinaga, N. J.Org.Chem. 1984, 49, 1056.
6. 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride